Intralesional collagenase in the treatment of Peyronie’s disease

Abstract

The objective of intralesional pharmacotherapy in the treatment of Peyronie's disease is to deliver large doses of pharmacologic agents that can have a local effect on wound remodeling, with minimal side effects. Guidelines for the treatment of peyronie's disease published in the Journal of Sexual Medicine and the European Association of Urology offer no grade A evidence of efficacy with multiple agents such as steroids, verapamil and interferon. Intralesional collagenase is the first drug to be approved by the United States Food and Drug Administration for the treatment of Peyronie's disease. This is based on grade A evidence. The purpose of this update is to review the literature and current data on intralesional collagenase in the treatment of Peyronie's disease.

Differential Effects of Processing Time and Duration of Collagenase Digestion on Human and Murine Fat Grafts

“…Further, collagenase as a biologic has been recently approved by the FDA (XIAFLEX®, Auxilium Pharmaceuticals) to treat Dupuytren's contracture 31 and Peyronie's disease 32 . With proper characterization and future studies to examine the effect of collagenase in more detail, FDA approval to enhance fat grafts with collagenase-isolated SVF may be imminent.…”

An overview on therapeutic potential and various applications of microbial collagenases

“…It works by breaking down the extra collagen in the penis that causes this disease [115]. A multicenter, double-blind, phase 3 randomized and placebo-controlled trial supports the efficacy and safety of intralesional CCH in the treatment of the subjective and objective aspects of significant Peyronie's disease in patients with curvature between 30° and 90° [116,117]. Recent studies demonstrated that CCH treatment administered in multiple cycles led to significant benefit in both the psychological and physical aspects of Peyronie's disease.…”

Complementary Proteomic and Biochemical Analysis of Peptidases in Lobster Gastric Juice Uncovers the Functional Role of Individual Enzymes in Food Digestion

“…These enzymes are not cysteine peptidases but serine peptidases, called brachyurins and are optimally active at neutral pH. Enzymes with collagenase activity have important therapeutic applications such as in wound healing (Agren et al 1992), treatment of Peyronie's disease (Honig 2014) and Dupuytren's contracture (Hurst et al 2009). Therefore, future studies by our group will assess if H. americanus cysteine cathepsin L2 has biochemical characteristics that are superior to the current therapeutic collagenases.…”