Intralesional Corticosteroid Therapy of Chalazia

Pizzarello, Louis D.; Hofeldt, Albert J.; Podolsky, Morris M.; Silvers, David N.

doi:10.1016/s0002-9394(14)78111-5

Cited by 70 publications

(26 citation statements)

References 4 publications

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“…Corticosteroid injection into the eyelids and orbit has been reported as a successful treatment for numerous periocular disease processes, such as capillary hemangioma, 13 thyroid ophthalmopathy, 14 chalazia, 15 sarcoid, 16 and vernal keratoconjunctivitis. 17 More inconsistent results have been reported with sporadic use of intralesional corticosteroids for the treatment of periocular NXG.…”

Section: Discussionmentioning

confidence: 99%

Local Corticosteroid Treatment of Eyelid and Orbital Xanthogranuloma

Elner¹,

Mintz²,

Demirci³

et al. 2006

Ophthalmic Plastic & Reconstructive Surgery

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Purpose: To demonstrate the efficacy of local corticosteroid therapy for the treatment of eyelid and orbital xanthogranuloma in adults.Methods: We performed a retrospective chart review of six patients receiving local triamcinolone acetonide (40 mg/mL) injections for the treatment of eyelid and orbital xanthogranuloma at the University of Michigan. All patients underwent diagnostic biopsy prior to treatment. The effects of this therapy on symptoms and signs of the disease were assessed.

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Section: Discussionmentioning

confidence: 99%

Local Corticosteroid Treatment of Eyelid and Orbital Xanthogranuloma

Elner¹,

Mintz²,

Demirci³

et al. 2006

Ophthalmic Plastic & Reconstructive Surgery

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“…It is difficult to predict who will have skin changes as they vary even in the same patient. Previous studies 5,12 reported skin changes in black patients. Our patient was a Chinese with fair skin 13 In our study, no change in IOP was encountered before and after extralesional triamcinolone injection, which is consistent with prior studies.…”

Section: Discussionmentioning

confidence: 99%

“…Several uncommon side-effects of local corticosteroid injection have been reported: yellow deposits at the site of injection, 5 depigmentation of the eyelid, 12 microembolisation causing retinal and choroidal vascular occlusion and appearance of granuloma. 4 In our study, one patient (6.3% of chalazia treated with triamcinolone injection) who had three chalazia developed skin hypopigmentary change at a right lower lid injection site.…”

Section: Discussionmentioning

confidence: 99%

“…1 Conservative management using lid hygiene, warm compresses, and topical antibiotics has been reported to have a success rate of up to 80%, 2-4 compared with 93% after intralesional corticosteroid injection. 2,[5][6][7][8][9] Intralesional steroid injection can be painful, whereas subcutaneous injection of triamcinolone acetonide suspension into the looser extralesional tissue may cause less pain. Leinfelder 10 reported using subconjunctival injection of methylprednisolone acetate to treat acute chalazion.…”

Section: Introductionmentioning

confidence: 99%

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Triamcinolone acetonide

&NA;

1995

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Objective. To compare the efficacy of subcutaneous extralesional triamcinolone acetonide injection versus conservative treatment for chalazion. Design. Randomised controlled trial. Setting. Eye clinics of two regional hospitals in Hong Kong. Patients. Patients over 18 years old presenting with primary chalazion were randomised into two groups. In group 1, 12 patients were treated with lid hygiene, warm compresses, and chloramphenicol 1% ointment 4 times a day. In group 2, 16 patients were treated with 0.3 mL triamcinolone acetonide (10 mg/mL) injection to the subcutaneous tissue extralesionally via the percutaneous route. Exclusion criteria were: acutely infected chalazion with preseptal cellulitis, recurrent chalazion, small chalazion (≤2 mm), and prior treatment to chalazion. Main outcome measures. Size of chalazion, recurrence of chalazion, intraocular pressure, and complications from treatment, including skin pigmentary change or atrophy and pyogenic granuloma.Results. There was a clinically and statistically significant difference between the success rates in group 1 (58.3%) and group 2 (93.8%). In group 1, the mean prior duration of chalazion before treatment was significantly shorter in success cases than in failed cases. One patient with multiple chalazia in group 2 developed hypopigmentary skin changes at one treatment site. Conclusion. Subcutaneous extralesional triamcinolone acetonide injection was more effective than conservative treatment for chalazion.

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“…Surgical treatments include steroids injections, CO2 laser treatment, lesion incision and curettage or total excision. 3,4 Several investigators have studied the effect of intralesional or subcutaneous steroid injection in the treatment of chronic chalazion with reported success and resolution in 50% to 95% of the cases. Injection is considered a simple and effective treatment, although serious adverse effects have been reported.…”

Section: Introductionmentioning

confidence: 99%

Role of Intralesional Triamcinolone Acetonide Injection in Treating Chalazion: Our Experience

Chakma¹,

Mazumder²,

Datta³

et al. 2013

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OBJECTIVE:To evaluate the safety and efficacy of intralesional triamcinolone acetonide (TA) injection in primary chalazion. DESIGN: Prospective, consecutive case series. MATERIALS AND METHOD: A prospective study of sixty six(66) patients with primary chalazion presenting to outpatient clinic of Department of Ophthalmology at Tripura medical college & Dr. B.R. Ambedkar Teaching Hospital, Agartala from 1 st December 2012 to 3o th September 2013. All patients received intralesional injection of 0.2ml TA (40mg/ml). Data regarding size including digital colour photography, lesion regression or recurrence, and complete ophthalmic examination, were recorded at the time of injection and at different intervals until resolution or surgical excision. Success was defined as at least 80% decrease in size with no recurrence. If the lesion recurred or regression was minimal (<50%), further injections were given as needed. Patients who did not respond to 3rd injections were referred for surgical incision and curettage. RESULT: Around 80% decrease in size of the lesion was noted in forty-eight (48) patients after 1 st injection (72.7%). Twelve (12) patients showed complete resolution of the lesion with 2 nd injection (18.17%). 3 rd injection was needed only in two (2) patients for satisfactory outcome. Four (4) patients were referred for incision and curettage that didn't show positive response after 3 rd injection also. Intraocular pressure and visual acuity remained stable after treatment. One patient developed depigmentation of the skin at the site of injection. No other major complications such as visual loss, subcutaneous fat atrophy were noted with steroid injections. CONCLUSION: Intralesional triamcinolone acetonide (TA) injection is a safe, effective and a simple method of treating primary chalazion where diagnosis is straightforward.

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Intralesional Corticosteroid Therapy of Chalazia

Cited by 70 publications

References 4 publications

Local Corticosteroid Treatment of Eyelid and Orbital Xanthogranuloma

Local Corticosteroid Treatment of Eyelid and Orbital Xanthogranuloma

Triamcinolone acetonide

Role of Intralesional Triamcinolone Acetonide Injection in Treating Chalazion: Our Experience

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