Intralesional immunotherapy for molluscum contagiosum: A review

Abstract

Molluscum contagiosum (MC) is a common cutaneous viral infection with no standard treatment. The virus responsible for MC is thought to be cleared by cell mediated immunity (CMI). Intralesional immunotherapy that stimulates CMI has been shown to be an effective treatment for other cutaneous viruses. In this review, we evaluate the efficacy and safety of intralesional immunotherapy in the treatment of MC. Articles met inclusion criteria if they examined the effects of intralesional immunotherapy as a treatment for MC, with a clear outcome and reproducible methodology. 228 studies were screened and 10 studies met criteria for inclusion. Intralesional immunotherapies investigated included candida, combined measles, mumps, rubella vaccine, tuberculin purified protein derivative, vitamin D3, inter

Two for One: Concurrent Acquisition of Molluscum Contagiosum Infection and Scabies Infestation After a Single Sexual Encounter

“…However, many patients--and especially older sexually active individuals--prefer interventional therapy. These modalities include mechanical methods, chemical methods, immunomodulatory methods, and antiviral therapy [ 1 , 2 , 4 , 11 , 12 ].…”

Topical and intralesional immunotherapy in cutaneous infections

“…[41] e topical immunomodulatory methods that have been tried in molluscum contagiosum are 5% imiquimod cream, diphencyprone, and topical sinecatechins. [2][3][4][5][6][7] Al-Mutairi et al, in a prospective, randomized, comparative, and observerblinded study, found imiquimod 5% cream applied 5 days a week to be of comparable efficacy (complete cure rate 91.8%) to weekly cryotherapy (complete cure rate 100%) at the end of 16 weeks. Pain, bullae formation, pigmentary changes, and superficial scarring were significantly more in the cryotherapy group.…”

“…[2] Intralesional immunotherapies [Table 2] used in molluscum contagiosum include measles-mumps-rubella vaccine, Candida, tuberculin PPD, vitamin D3, interferon α, and Streptococcal substrain OK-432. [5][6][7] Nelson et al reported 10 patients with HIV infection who received intralesional IFN α (one mega unit) at weekly intervals for 4 weeks. ree Mollusca of each patient were chosen for treatment.…”

“…[6] After reviewing 10 studies on intralesional immunotherapy for molluscum contagiosum, Wells et al concluded that none of the patients who completely responded to Candida, MMR vaccine, OK-432, and vitamin D3 showed recurrence after immunotherapy, while intralesional PPD and interferon α showed less efficacy in preventing recurrences. [7]…”

“…[1] Molluscum contagiosum, recurrent herpes labialis, and genitalis and cutaneous leishmaniasis are the other cutaneous infections where immunotherapy is found effective. [2][3][4][5][6][7][8][9][10] is review focuses on the topical/intralesional agents used in cutaneous infections. e common topical agents used are imiquimod 5% cream, diphenylcyclopropenone (DPCP) (diphencyprone), squaric acid dibutyl ester (SADBE), 15% sinecatechins ointment, Bacillus Calmette-Guerin (BCG) vaccine in normal saline or salicylic acid, and 15% zinc ointment.…”