Background Infantile hemangiomas (IH) are the most common soft-tissue tumors of infancy, but little is known regarding their true incidence. Objectives To determine the current incidence of IH and examine trends in incidence, demographics, and lesion characteristics over three decades. Methods The Rochester Epidemiology Project was used to identify infants residing in Olmsted County, Minnesota, who were diagnosed with IH between January 1, 1976 and December 31, 2010. Results Nine hundred and ninety-nine infants were diagnosed with IH. Incidence increased over the 3- decade study period from 0.97 per 100 person-years to 1.97 per 100 person years (p<0.001). Average gestational age at birth and birth weight for infants with IH decreased over the study period (39.2 to 38.3 weeks, p<0.001 and 3383 to 3185 grams, p=0.003, respectively). The overall age- and sex-adjusted incidence of IH was 1.64 per 100 person-years (95% CI 1.54–1.75). Limitations The population of Olmsted County is predominantly non-Hispanic white, limiting our ability to report racial differences in incidence. This was a retrospective study. Conclusions This study provides a longitudinal, population-based incidence of IH. Incidence has increased steadily over the past three decades, correlating significantly with decreasing gestational age at birth and birth weight in affected infants.

The α3β4 subtype of nicotinic acetylcholine receptors (nAChRs) has been implicated in mediating nicotine reinforcement processes. AT-1001 has been recently described as a high-affinity and selective α3β4 nAChR antagonist that blocks nicotine self-administration in rats. The aim of this study was to investigate the mechanism of action underlying the nicotine-suppressive effects of AT-1001

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Pediatric PG has a more varied anatomic distribution and a greater predominance of pustular lesions than PG in adults and a strong association with inflammatory bowel disease.