Pediatric Pyoderma Gangrenosum: A Retrospective Review of Clinical Features, Etiologic Associations, and Treatment

Schoch, Jennifer J.; Tolkachjov, Stanislav N.; Cappel, Jonathan A.; Gibson, Lawrence E.; Davis, Dawn M.

doi:10.1111/pde.12990

Cited by 36 publications

(45 citation statements)

References 26 publications

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“…In contrast, in adolescent's IBD was the largely predominant associated disease. In agreement with our observations in adolescents, IBD represents the most common general disease associated with ND, accounting for 20–30% of adult PG cases . Thus, in young children presenting with ND, clinicians need to consider the possibility of an association with a larger spectrum of general diseases and genetic autoinflammatory syndromes.…”

Section: Discussionsupporting

confidence: 89%

“…In agreement with our observations in adolescents, IBD represents the most common general disease associated with ND, accounting for 20-30% of adult PG cases. 16,17,33,34 Thus, in young children presenting with ND, clinicians need to consider the possibility of an association with a larger spectrum of general diseases and genetic autoinflammatory syndromes. This may justify a more extensive diagnostic workup for ND occurring in small children than in adults.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Age‐specific characteristics of neutrophilic dermatoses and neutrophilic diseases in children

Bucchia

Barbarot

Reumaux

et al. 2019

Acad Dermatol Venereol

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Background Our suggested ‘modern’ concepts of ‘neutrophilic dermatoses’ (ND) and ‘neutrophilic disease’ were based on observations in adult patients and have not been studied in paediatric patients. Only a minority of ND occurs in children, and little is known about age‐specific characteristics. Objectives To describe age‐specific characteristics of ND in children and to study whether our suggested ‘modern’ classification of ND may be applied to children. Methods We conducted a retrospective multicentre study in a French cohort of 27 paediatric patients diagnosed with pyoderma gangrenosum (PG) or Sweet's syndrome (SS). Results Demographics and distribution of typical/atypical forms were similar in patients diagnosed with PG and SS. Atypical ND were more frequent in infants (90%), when compared to young children (60%) and adolescents (33%). Neutrophilic disease was observed in 17/27 patients and was most frequent in infants. Neutrophilic disease of the upper respiratory tract, as well as cardiac neutrophilic disease, was only observed in infants, whereas other locations were similarly found in infants, young children and adolescents. In infants and young children, ND were associated with a large spectrum of general diseases, whereas in adolescents associations were limited to inflammatory bowel disease and Behçet's disease. Conclusions Our study describes the concept of ND in paediatric patients and shows that they have some characteristics different from ND occurring in adults. ND occurring in infants can be associated with a large spectrum of general diseases. Occurrence of neutrophilic disease is frequent in children. Thus, ND occurring in young paediatric patients should incite clinicians to schedule complementary explorations in order to search for involvement of other organs and to rule out monogenetic autoinflammatory syndromes.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Age‐specific characteristics of neutrophilic dermatoses and neutrophilic diseases in children

Bucchia

Barbarot

Reumaux

et al. 2019

Acad Dermatol Venereol

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“…Clinical features of PG in children have been described in the literature . Children with PG are more likely to have involvement of the head and neck and pathergy.…”

Section: Discussionmentioning

confidence: 82%

“…Clinical features of PG in children have been described in the literature. 24 Children with PG are more likely to have involvement of the head and neck and pathergy. Lesions in children are also more likely to start as inflammatory pustules and evolve rapidly into ulcerative and necrotic plaques.…”

Section: Discussionmentioning

confidence: 99%

Pyoderma gangrenosum in an infant: A case report and review of the literature

Crouse

McShane

Morrell

et al. 2018

Pediatric Dermatology

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Pyoderma gangrenosum is a neutrophilic dermatosis that is rare in infancy, with only 20 cases reported in the literature. We present a case of infantile pyoderma gangrenosum refractory to topical steroids, tacrolimus, and dapsone as well as systemic steroids and infliximab that is currently well controlled with the addition of oral tacrolimus. To our knowledge, this is the first report of the effective, safe use of oral tacrolimus in combination with infliximab for infantile pyoderma gangrenosum. We review all current cases of infantile pyoderma gangrenosum, as well as tacrolimus and its role in the treatment of this condition.

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“…Other reported association was pediatric vasculitis with Behcet's and Takayasu's disease or immune deficiency. More recently, PG has been associated with novel drug therapies like pegfilgrastim, gefitinib, and other autoinflammatory syndromes including PAPA (pyogenic arthritis, PG, and acne), PAPASH (pyogenic arthritis, PG, acne, and hidradenitis suppurativa), and PASH (PG, acne, hidradenitis suppurativa) …”

Section: What Is the Diagnosis?mentioning

confidence: 99%

Cutaneous ulceration in an infant

Garbayo-Salmons

Andreu

González

et al. 2019

Pediatric Dermatology

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Pediatric Pyoderma Gangrenosum: A Retrospective Review of Clinical Features, Etiologic Associations, and Treatment

Abstract: Pediatric PG has a more varied anatomic distribution and a greater predominance of pustular lesions than PG in adults and a strong association with inflammatory bowel disease.

Cited by 36 publications

References 26 publications

Age‐specific characteristics of neutrophilic dermatoses and neutrophilic diseases in children

Age‐specific characteristics of neutrophilic dermatoses and neutrophilic diseases in children

Pyoderma gangrenosum in an infant: A case report and review of the literature

Cutaneous ulceration in an infant

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