Intralesional injection of platelet-rich plasma followed by controlled exercise for treatment of midbody suspensory ligament desmitis in Standardbred racehorses

Waselau, Martin; Sutter, Willy; Genovese, Ronald L.; Bertone, Alicia L.

doi:10.2460/javma.232.10.1515

Cited by 120 publications

(144 citation statements)

References 28 publications

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“…The stress at failure (s max ) was calculated [s max ¼ F max /cross-sectional area (N/mm 2 ¼ MPa)] and the modulus of elasticity (EM), was deduced from the slope of the linear part of the curve. 12 Results of the two slices were averaged.…”

Section: Biomechanical Testingmentioning

confidence: 99%

“…PRP has been used successfully in maxillofacial surgery to accelerate soft tissue and bone healing, 7 and is currently under investigation for a possible role in regeneration of tendons. 8,9 PRP treatment of tendon disorders appeared to be effective in human and equine patients, [10][11][12] and studies using laboratory animals or in vitro methods have elucidated some of the working mechanisms. 8,9,13,14 Platelets are known to play a crucial role in the cascade of tissue healing by delivering growth factors to the site of injury.…”

mentioning

confidence: 99%

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Effects of platelet‐rich plasma on the quality of repair of mechanically induced core lesions in equine superficial digital flexor tendons: A placebo‐controlled experimental study

Bosch

Schie

Groot

et al. 2009

Journal Orthopaedic Research

210

241

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Tendon injuries are notorious for their slow and functionally inferior healing. Intratendinous application of platelet-rich plasma (PRP) has been reported to stimulate the repair process of tendon injuries, but there is little conclusive evidence for its effectiveness. A placebo-controlled experimental trial was performed to test the hypothesis that a single intratendinous PRP treatment enhances the quality of tendon repair, as evidenced by improved biochemical, biomechanical, and histological tissue properties. In six horses, tendon lesions were created surgically in the Superficial Digital Flexor Tendons (SDFT) of both front limbs, one of which was treated with PRP and the other with saline. After 24 weeks, the tendons were harvested for biochemical, biomechanical, and histological evaluations. Collagen, glycosaminoglycan, and DNA content (cellularity) was higher in PRP-treated tendons (p ¼ 0.039, 0.038, and 0.034, respectively). The repair tissue in the PRP group showed a higher strength at failure (p ¼ 0.021) and Elastic Modulus (p ¼ 0.019). Histologically, PRP-treated tendons featured better organization of the collagen network (p ¼ 0.031) and signs of increased metabolic activity (p ¼ 0.031). It was concluded that PRP increases metabolic activity and seems to advance maturation of repair tissue over nontreated experimentally induced tendon lesions, which suggests that PRP might be beneficial in the treatment of clinical tendon injuries. ß

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Section: Biomechanical Testingmentioning

confidence: 99%

mentioning

confidence: 99%

Effects of platelet‐rich plasma on the quality of repair of mechanically induced core lesions in equine superficial digital flexor tendons: A placebo‐controlled experimental study

Bosch

Schie

Groot

et al. 2009

Journal Orthopaedic Research

210

241

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“…The first clinical application of platelet rich plasma (PRP) was published by Marx et al (1998) in the supportive treatment of mandibular defects in humans with bony implants. More recently, PRP was used in human and equine sport medicine for therapy defects in ligaments and tendons (Mishra and Pavelko 2006;Arguelles et al 2008;Waselau et al 2008). A great advantage of autologous PRP therapy is the lack of immunological response in the treated organism (Kajikawa et al 2008).…”

mentioning

confidence: 99%

Platelet rich plasma treatment of superficial digital flexor tendon lesions in racing Thoroughbreds

Žuffová¹,

Krisová²,

Žert³

2013

Vet. Med. - Czech

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ABSTRACT:The main goal of this study was to evaluate the effectiveness of a modified method for preparing platelet rich plasma for the treatment of superficial digital flexor tendon lesions in race horses and its influence on the future recuperation of the animals. The applied concentrate of plasma was prepared by centrifugation followed by aspiration close above the buffy coat. There were no negative reactions resulting from the application of the biological material into the damaged tendons. The success of the therapy was proven by the shortened rehabilitation time and the higher number of horses returning to racing.

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“…Além disso, todos os animais retornaram ao nível esportivo anterior à lesão e não apresentaram recidivas até 20 meses após. Waselau et al (2008) Rindermann et al (2010) conduziram um estudo com seis equinos que apresentavam variados graus de tendinite, porém sem um grupo controle. Os resultados ultrassonográficos revelaram diminuição no percentual de área lesada, na área seccional total do tendão, melhora no grau de ecogenicidade e no alinhamento das fibras.…”

Section: Argüelles Et Al (2006) Usaram Concentradounclassified

Uso do soro autólogo condicionado e do plasma rico em plaquetas na terapia ortopédica de equinos

et al. 2014

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ResumoAs lesões musculoesqueléticas que ocorrem durante a prática esportiva em equinos são debilitantes e demandam um longo período de tratamento e reabilitação, para muitas vezes obter-se após o tratamento apenas um tecido cicatricial, predispondo à recidiva. Em busca de terapias mais efetivas e da reparação tecidual de melhor qualidade, tem sido estudada a utilização de derivados sanguíneos, como plasma rico em plaquetas e soro autólogo condicionado. Apesar de ambos serem considerados hemoderivados, o soro autólogo condicionado e o plasma rico em plaquetas são produtos distintos com indicações totalmente diferentes para seu uso. Em lesões tendíneas e ligamentares o plasma rico em plaquetas apresenta resultado promissor em estudos clínicos e experimentais. Nas lesões osteoarticulares estes resultados são obtidos tanto com o soro autólogo condicionado como com o plasma rico em plaquetas. A presente revisão tem como objetivo apresentar estudos clínicos e experimentais (in vivo e in vitro) na espécie equina, que auxiliem na escolha do melhor hemoderivado a ser utilizado frente às diferentes lesões musculoesqueléticas. Palavras-chave: Plasma rico em plaquetas, soro autólogo condicionado, tendão, ligamento, articulação, músculo AbstractMusculoskeletal injuries that occur in horses during sports activities are often disabling and require a long period of treatment and rehabilitation, most resulting in scar tissue, predisposing to recurrence. In search of more effective therapies and tissue regeneration, studies have been carried out with blood derivatives -platelet rich plasma and autologous conditioned serum. In spite of both being bloodderived therapies, platelet rich plasma and autologous conditioned serum are distinct products, with equally distinct indications for their use. Platelet rich plasma shows promising results in ligament and tendon injuries in clinical and experimental trials. This occurs also in osteoarticular lesions with both hemoderivates, autologous conditioned serum and platelet rich plasma. This review aims to present clinical and experimental studies (in vivo and in vitro) in the equine species, as an aid for an appropriate therapeutic choice, when hemoderivates are considered for treatment of musculoskeletal lesions.

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Intralesional injection of platelet-rich plasma followed by controlled exercise for treatment of midbody suspensory ligament desmitis in Standardbred racehorses

Abstract: Results suggested that horses with moderate to severe MSD treated by means of intralesional injection of a single dose of PRP followed by a program of gradually increased exercise had an excellent prognosis for returning to racing.

Cited by 120 publications

References 28 publications

Effects of platelet‐rich plasma on the quality of repair of mechanically induced core lesions in equine superficial digital flexor tendons: A placebo‐controlled experimental study

Effects of platelet‐rich plasma on the quality of repair of mechanically induced core lesions in equine superficial digital flexor tendons: A placebo‐controlled experimental study

Platelet rich plasma treatment of superficial digital flexor tendon lesions in racing Thoroughbreds

Uso do soro autólogo condicionado e do plasma rico em plaquetas na terapia ortopédica de equinos

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