Intralesional triamcinolone alone or in combination with 5-fluorouracil for the treatment of keloid and hypertrophic scars

Darougheh, Afshin; Asilian, Ali; Shariati, F.

doi:10.1111/j.1365-2230.2007.02631.x

Cited by 148 publications

(148 citation statements)

References 24 publications

(55 reference statements)

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“…[29][30] Thus the present study coincides with the above studies with respect to improvement in size of keloid. The above table shows adverse effects are less in the present study in both groups when compared to A. Darougheh et al study but is statistically significant with p value < 0.05(0.02).…”

Section: Treatment Outcome In 2 Groupssupporting

confidence: 76%

A comparative study between intralesional 5-fluorouracil combined with triamcinolone acetonide and triamcinolone acetonide alone in the treatment of keloids

Nagarur

Raja

2016

Int J Basic Clin Pharmacol

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Section: Treatment Outcome In 2 Groupssupporting

confidence: 76%

A comparative study between intralesional 5-fluorouracil combined with triamcinolone acetonide and triamcinolone acetonide alone in the treatment of keloids

Nagarur

Raja

2016

Int J Basic Clin Pharmacol

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“…Systemic injection of 5-FU can cause anemia, leukopenia and thrombocytopenia. However, intralesional injection of up to 25 mg of 5-FU or even a high dosage do not lead to these systemic complications of 5-FU (10,23).…”

Section: Discussionmentioning

confidence: 99%

“…Intralesional 5-FU is generally well tolerated. The frequently encountered adverse effects include pain at the injection site, ulceration, burning and hyperpigmentation (23)(24)(25). Systemic injection of 5-FU can cause anemia, leukopenia and thrombocytopenia.…”

Section: Discussionmentioning

confidence: 99%

Combined effects of long-pulsed neodymium-yttrium-aluminum-garnet laser, diprospan and 5-fluorouracil in the treatment of keloid scars

Xiao-E

Liu

Jameel

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Keloids are benign tumors that originate from scar tissues, but they usually overgrow beyond the original wounds. In a three-month single-center clinical trial, 69 patients were randomly divided into three groups. Patients in group 1 were treated with intralesional injection of diprospan (2 mg betamethasone disodium phosphate and 5 mg betamethasone dipropionate in 1 ml) with one-month intervals for three months. Patients in groups 2 and 3 were injected with a combination of 0.5 ml 5-fluorouracil (5-FU; 25 mg/ml) and diprospan as above for three months also. Prior to each injection, the keloids of patients in group 3 were additionally irradiated by a 1,064-nm neodymium-yttrium-aluminum-ga rnet (Nd:YAG) laser with a single pulse at an energy density of 90-100 J/cm 2 and a pulse width of 12 msec. Clinical responses were evaluated by patient self-assessment and overall assessment by an observer according to the clinical signs of erythema, pruritus and pliability. A total of sixty-two patients completed the tests of the present study. At 2 and 3 months, the patients in all treatment groups showed an acceptable improvement in nearly all measurements. At the end of the study, the erythema and toughness score was significantly reduced and itch reduction was significantly greater in the diprospan + 5-FU + Nd:YAG group when compared to those in the other groups (P<0.05 for all indexes). The acceptable responses (good to excellent improvements) reported by blinded observers were as follows: 12% in the diprospan group, 48% in the diprospan + 5-FU group and 69% in the diprospan + 5-FU + Nd:YAG group. All of the results indicated that the combination of diprospan + 5-FU + Nd:YAG was the most efficacious therapy for keloid scars.

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“…The keloid can be also treated with injections consisting of steroid and 5-fluoroacil. These two combined drugs appear to bring better results rather than when they are administered separately [16].…”

Section: Common Therapeutic Methodsmentioning

confidence: 99%

Keloids: current prophylactic and therapeutic methods

Bienias¹,

Kaszuba²

2012

pdia

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A b s t r a c tProphylaxis and therapy of keloids present a big challenge for medicine, despite the increasing knowledge about their pathogenesis. There are a lot of therapeutic methods but their effectiveness is still limited and unsatisfactory. These methods are divided into surgical, pharmacological and physical ones as well as the most frequently applied combined therapy, which is the most effective one. A surgical way of removing keloids is becoming less common and the method of intralesional application of steroids still remains the treatment of choice. In addition to the above there are cryotherapy, laser therapy, pressure therapy, X-ray irradiation and silicone products in a form of gels and dressings. Relatively new methods are intralesional injections of verapamil and 5-fluorouracil. Enalapril and troglitazone, which are currently used in the treatment of hypertension and diabetes, are expected to be of use as well. Biological drugs like monoclonal antibodies against tumor growth factor (TGF)-β1, TGF-β2 and vascular endothelial growth factor and analogues of TGF-β3 are also potential solutions in the treatment of keloids. Further studies on the treatment of keloids should result in more efficient therapies. K Ke ey y w wo or rd ds s: :

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Intralesional triamcinolone alone or in combination with 5-fluorouracil for the treatment of keloid and hypertrophic scars

Abstract: The overall efficacy of TAC + 5-FU was comparable with TAC, but the TAC + 5-FU combination was more acceptable to patients and produced better results.

Cited by 148 publications

References 24 publications

A comparative study between intralesional 5-fluorouracil combined with triamcinolone acetonide and triamcinolone acetonide alone in the treatment of keloids

A comparative study between intralesional 5-fluorouracil combined with triamcinolone acetonide and triamcinolone acetonide alone in the treatment of keloids

Combined effects of long-pulsed neodymium-yttrium-aluminum-garnet laser, diprospan and 5-fluorouracil in the treatment of keloid scars

Keloids: current prophylactic and therapeutic methods

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