Intralesional Vitamin D Injection May Be an Effective Treatment Option for Warts

Aktaş, Habibullah; Ergin, Can; Demir, Betül; Ekiz, Özlem

doi:10.1177/1203475415602841

Cited by 79 publications

(109 citation statements)

References 24 publications

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“…80% experienced complete resolution while one patient has partial response and 3 failed to show any response. 29 While in our study 72.5% (29 patients) showed complete response and 8 patients showed marked to moderate response and 3 patients showed no response.…”

Section: Discussionmentioning

confidence: 40%

“…It also acts on Toll-like receptor activation which causes human macrophages up-regulation and expression of VDR and vitamin D 1 -hydroxylase genes, leading to expression and secretion of antimicrobial peptides. 28,29 Topical form of vitamin D3 has been used for common as well as anogenital warts showing good results. Topical vitamin D3 was successfully used by Moscarelli et al in a renal transplant patient to treat recalcitrant wart.…”

Section: Discussionmentioning

confidence: 99%

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A comparative study between intralesional PPD and vitamin D3 in treatment of viral warts

et al. 2018

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Background: Viral warts are caused by human papillomavirus. There are innumerable treatment modalities but they may result in partial clearance or recurrence. Some newer and effective treatments include intralesional immunotherapy. We undertook a study to evaluate the safety and efficacy of two such immunotherapy namely tuberculin purified protein derivative (PPD) versus intralesional vitamin D3 for the treatment of viral warts.Methods: A total of 80 patients were included in the study. Group 1 patient were injected with 10 TU of tuberculin PPD (0.1 ml) intralesional while in group 2 patients were injected (0.5 ml) vitamin D3. The clinical assessment was done by photographic measurements at baseline, before each treatment session, and after the completion of treatment.Results: In group 1 A total of 80% (32 patients) showed complete clearance and 20% (8 patients) showed partial response while in group 2 72.5% (29 patients) showed complete clearance while 27.5% (11 patients) showed partial response. No significant side effects were observed except for pain at the site of injection.Conclusions: Intralesional vitamin D and intralesional Tuberculin PPD immunotherapy shows significant results in treatment of viral warts.

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Section: Discussionmentioning

confidence: 40%

Section: Discussionmentioning

confidence: 99%

A comparative study between intralesional PPD and vitamin D3 in treatment of viral warts

et al. 2018

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“…Using a 21‐gauge syringe, 0.2 mL of vitamin D3 (7.5 mg/mL) solution was slowly injected into the base of each wart. The maximum amount of vitamin D3 injected into a patient per session was 7.5 mg (Aktaş et al, ). If incomplete resolution was obtained after the first session, another session was done after 4 weeks.…”

Section: Methodsmentioning

confidence: 99%

“…Topical (Moscarelli et al, ) and intralesional vitamin D (Aktaş, Ergin, Demir, & Ekiz, ) have been used successfully for wart treatment. The effects of vitamin D are mediated via the vitamin D receptor (VDR), which is present in keratinocytes, melanocytes, fibroblasts, and immune system cells of the skin (Al Ghamdi, Kumar, & Moussa, ).…”

Section: Introductionmentioning

confidence: 99%

Cigarette smoking reduces the efficacy of intralesional vitamin D in the treatment of warts

El-Taweel

Salem

Allam³

2019

Dermatologic Therapy

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Cigarette smoking may decrease serum levels of vitamin D and reduce its efficacy. We aimed to evaluate the safety and efficacy of intralesional vitamin D in the treatment of warts and to investigate the effect of smoking on its efficacy in these cases. The study included 20 patients with verruca vulgaris and deep palmoplantar warts. The wart to be injected was cleaned by alcohol and then injected with 0.1 mL of prilocaine (20 mg/mL). 0.2 mL of vitamin D3 (7.5 mg/mL) solution was slowly injected into the base of each wart. The maximum total amount of vitamin D3 injected into a patient in one session was 7.5 mg. The injection was done at 4 weeks interval until clearance or for a maximum of two sessions. Clinical and dermoscopic follow‐up of the treated and distant warts was carried out. Forty percent of the treated lesions showed complete clearance and the rate of distant wart response was 17.65%. Among different demographic and clinical variables in the studied patients, smoking and older age seemed to decrease the therapeutic response Intralesional vitamin D is effective in the treatment of warts, however, smoking and aging may reduce its efficacy.

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“…Different treatment options have been tried with varying efficacy including keratolytics, cryotherapy, electrocautery, laser ablation, intralesional bleomycin, microneedling, Vitamin D injections, vaccination, photodynamic therapy, and oral cimetidine. [111213] Usage of immunotherapy for viral warts was first described by Lewis in 1973 with dinitrochlorobenzene. DPCP was first used in the treatment of warts in 1984.…”

Section: Discussionmentioning

confidence: 99%

A case report of verruca vulgaris on basis of alopecia areata successfully treated with diphenylcyclopropenone

et al. 2017

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Alopecia areata is an autoimmune skin disease which is usually characterized by patchy hair loss in effected regions. Diagnosis usually based on clinical findings and main treatment options include topical, intralesional, systemic corticosteroids, and topical immunotherapy. Verruca vulgaris is an infectious disease caused by human papillomavirus which is usually characterized by well-marginated hyperkeratotic papules or plaques. There are several treatment modalities such as physical and chemical destruction and topical immunotherapy. A 23-year-old male patient presented to our outpatient clinic with multifocal noncicatrial alopecic plaques on scalp and multiple periungual verrucous papules on bilateral hands. High potent corticosteroid cream and minoxidil lotion 5% were offered for his scalp lesions, and topical 5-fluorouracil lotion was initiated for his verrucous lesions. In the 1st month visit, we detected contamination of viral warts on alopecic plaques of his scalp and all the previous therapeutics were stopped. We initiated topical diphenylcyclopropenone (DPCP) sensitization weekly. After the fourth application of DPCP, we observed that all of hyperkeratotic papules disappeared. Diphencyprone treatment was continued, and with further applications, hair growth as vellus type was observed. DPCP is relatively beneficial treatment option for both diseases although it is not a first-line therapy most times. There are case reports and series about this treatment for both of these diseases. We want to present this case to by regard of the unusual presentation and efficacy of DPCP in both indications.

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Intralesional Vitamin D Injection May Be an Effective Treatment Option for Warts

Abstract: Intralesional vitamin D(3) may be an effective treatment option for warts.

Cited by 79 publications

References 24 publications

A comparative study between intralesional PPD and vitamin D3 in treatment of viral warts

A comparative study between intralesional PPD and vitamin D3 in treatment of viral warts

Cigarette smoking reduces the efficacy of intralesional vitamin D in the treatment of warts

A case report of verruca vulgaris on basis of alopecia areata successfully treated with diphenylcyclopropenone

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