Intraluminal administration of zingerol, a non-pungent analogue of zingerone, inhibits colonic motility in rats

Abstract

Zingerone, a pungent component of ginger, may exert beneficial therapeutic effects on hypermotilityinduced diarrhea because it has the ability to inhibit contractions of colonic smooth muscles. However, the pungency is undesirable for possible therapeutic use. The purpose of this study was to examine effects of zingerol, a non-pungent analogue of zingerone, in rats. Colonic motility in vivo was evaluated by measuring intraluminal pressure changes and expelled fluid volume from the colon in anesthetized rats. Mechanical contractile activities of isolated colonic segments were also recorded. Intracolonic administration of zingerol attenuated colonic motility in vivo without affecting blood pressure and heart rate in a manner similar to that of zingerone. Zingerol also inhibited spontaneous contractile movements in isolated colonic segments, suggesting that zingerol directly acts on the colon. Zingerol had no effect on jejunal motility, although zingerone showed an inhibitory effect to the jejunum. These findings suggest that zingerol can inhibit colonic motility without adverse effects on small intestinal motility and the cardiovascular system. The non-pungent property of zingerol will be useful as an oral or suppository medicine for treating diarrhea and other gastrointestinal disorders.

Ginger—Mechanism of action in chemotherapy-induced nausea and vomiting: A review

“…(Sharma and Gupta, 1998) In contrast, the ginger compounds zingerone and zingerol as well as whole ginger were reported to inhibit colonic motility in rats. (Iwami et al, 2011a;Iwami et al, 2011b) These diverse results indicate that ginger's effects could be a ACCEPTED MANUSCRIPT ACCEPTED MANUSCRIPT 10 result of the particular concentration of different bioactive compounds, or the synergy between them.…”

The Effect of Ginger Hydroalcholic Extract on Rat Ileal Contraction in Vitro

“…It was demonstrated that ginger accelerated gastric motility such as emptying and antral contractions in healthy volunteers and in patients with functional dyspepsia [12]. However about lower gastrointestinal region there are controversial reports [18][19][20].…”

“…In digestive tract, it has been demonstrated that ginger extract abolished the chemotherapy induced delay in gastric emptying in rats [16] and also it reduced nausea associated with motion sickness [17]. Moreover in rat colon it has been shown that ginger extract decrease motility [18]. While in the rat ileum it has spasmolytic effect [19], in guinea pig ileum ginger improves motility [20].…”

“…Isolated gingerols and shogaols have been shown to modify gastric motility in animal experiments [21]. Although it was demonstrated that ginger accelerated gastric motility [12], about lower gastrointestinal region there are paradoxical information [18][19][20]. It seems that the effect of ginger in gastrointestinal tract motility, depends to organ and spices and different in upper and lower part of gastrointestinal tract.…”

Antibacterial and Antidiarrheal Activities of Plant Products against Enterotoxinogenic Escherichia coli

“…The effects were reversible and reproducible. As the pungency is undesirable in therapeutic use, an analogue of zingerone, zingerol was tested afterwards [112]. This compound had no inhibitory effect on the jejunum, inhibiting the contractile movements in isolated colonic segments only, suggesting it was directly acting on the colon.…”