Intraluminal fiber-optic Doppler imaging catheter for structural and functional optical coherence tomography

Li, Xing De; Ko, Tony H.; Fujimoto, James G.

doi:10.1117/12.470471

Cited by 8 publications

(9 citation statements)

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“…These clinical studies suggest that rotary catheters provide useful in-vivo diagnostic information based on the structural morphology in the tissue. Doppler OCT, an extension of OCT, has been used with rotary catheter probes to visualize and quantify flow [4][5][6]. The ability to measure flow and microvascular architectures may provide insight into the detection and progression of various diseases.…”

Section: Introductionmentioning

confidence: 99%

High speed, wide velocity dynamic range Doppler optical coherence tomography (Part IV): split spectrum processing in rotary catheter probes

Vuong¹,

Lee²,

Luk³

et al. 2014

Opt. Express

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We report a technique for blood flow detection using split spectrum Doppler optical coherence tomography (ssDOCT) that shows improved sensitivity over existing Doppler OCT methods. In ssDOCT, the Doppler signal is averaged over multiple sub-bands of the interferogram, increasing the SNR of the Doppler signal. We explore the parameterization of this technique in terms of number of sub-band windows, width and overlap of the windows, and their effect on the Doppler signal to noise in a flow phantom. Compared to conventional DOCT, ssDOCT processing has increased flow sensitivity. We demonstrate the effectiveness of ssDOCT in-vivo for intravascular flow detection within a porcine carotid artery and for microvascular vessel detection in human pulmonary imaging, using rotary catheter probes. To our knowledge, this is the first report of visualizing in-vivo Doppler flow patterns adjacent to stent struts in the carotid artery.

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Section: Introductionmentioning

confidence: 99%

High speed, wide velocity dynamic range Doppler optical coherence tomography (Part IV): split spectrum processing in rotary catheter probes

Vuong¹,

Lee²,

Luk³

et al. 2014

Opt. Express

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“…6 A design by Li et al used a beam that exited the envelope at an oblique angle for better Doppler flow resolution in an artery. 8 An off-normal beam exit angle also suppresses the collection of specular back reflection from the window surface. 9,10…”

Section: Optical Considerations In Ultrahigh-resolution Oct Endoscopesmentioning

confidence: 99%

In vivo ultrahigh-resolution optical coherence tomography of mouse colon with an achromatized endoscope

Tumlinson¹,

Považay²,

Hariri³

et al. 2006

J. Biomed. Opt.

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Endoscopic ultrahigh-resolution optical coherence tomography (OCT) enables collection of minimally invasive cross-sectional images in vivo, which may be used to facilitate rapid development of reliable mouse models of colon disease as well as assess chemopreventive and therapeutic agents. The small physical scale of mouse colon makes light penetration less problematic than in other tissues and high resolution acutely necessary. In our 2-mm diameter endoscopic time domain OCT system, isotropic ultrahigh-resolution is supported by a center wavelength of 800 nm and full-width-at-half-maximum bandwidth of 150 nm (mode-locked titanium:sapphire laser) combined with 1:1 conjugate imaging of a small core fiber. A pair of KZFSN5/SFPL53 doublets provides excellent color correction to support wide bandwidth throughout the imaging depth. A slight deviation from normal beam exit angle suppresses collection of the strong back reflection at the exit window surface. Our system achieves axial resolution of 3.2 microm in air and 4.4-microm lateral spot diameter with 101-dB sensitivity. Microscopic features too small to see in mouse tissue with conventional resolution systems, including colonic crypts, are clearly resolved. Resolution near the cellular level is potentially capable of identifying abnormal crypt formation and dysplastic cellular organization.

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“…Optical coherence tomography (OCT) [1] is finding widespread applications in biomedical imaging, with micrometer spatial resolution [2,3] and its Doppler extension can image blood flow with velocity ranging from 0.02 to 100 mm/s [4]. High-speed wavelength-swept light sources have become available, and OCT techniques have been improved with Fourier domain measurements [5][6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

High power wavelength linearly swept mode locked fiber laser for OCT imaging

et al. 2008

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We report a long coherence length, high power, and wide tuning range wavelength linearly swept fiber mode-locked laser based on polygon scanning filters. An output power of 52.6 mW with 112 nm wavelength tuning range at 62.6 kHz sweeping rate has been achieved. The coherence length is long enough to enable imaging over 8.1 mm depth when the sensitivity decreases by 8.7 dB (1/e(2)). The Fourier components are still distinguishable when the ranging depth exceeds 15 mm, which corresponds to 30 mm optical path difference in air. The parameters that are critical to OCT imaging quality such as polygon filter linewidth, the laser coherence length, output power, axial resolution and the Fourier sensitivity have been investigated theoretically and experimentally. Since the wavelength is swept linearly with time, an analytical approach has been developed for transforming the interference signal from equidistant spacing in wavelength to equidistant spacing in frequency. Axial resolution of 7.9 microm in air has been achieved experimentally that approaches the theoretical limit.

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Intraluminal fiber-optic Doppler imaging catheter for structural and functional optical coherence tomography

Cited by 8 publications

References 0 publications

High speed, wide velocity dynamic range Doppler optical coherence tomography (Part IV): split spectrum processing in rotary catheter probes

High speed, wide velocity dynamic range Doppler optical coherence tomography (Part IV): split spectrum processing in rotary catheter probes

In vivo ultrahigh-resolution optical coherence tomography of mouse colon with an achromatized endoscope

High power wavelength linearly swept mode locked fiber laser for OCT imaging

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