Intramammary Application of Ozone Therapy to Acute Clinical Mastitis in Dairy Cows.

Ogata, Atsuya; Nagahata, Hajime

doi:10.1292/jvms.62.681

Cited by 54 publications

(47 citation statements)

References 12 publications

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“…The mechanism of ozone sterilization involves destruction of the microbial cell membrane, and its sterilization power is proportionate to contact time and density. Many studies have documented use of ozone administration into the blood or body as a medical treatment [5], and some studies have documented it use in veterinary medicine [9,11]. Use of ozone as a therapy for acute mastitis does not produce serious side effects such as endotoxin shock, and the cure rate of acute mastitis with ozone therapy is higher than that with the conventional treatment method [9].…”

mentioning

confidence: 99%

“…The use of ozone is spreading as a treatment for masititis [9], particularly because of the high cure rate of coliform mastitis with intramammary application of ozone gas. It has been reported that compared with antibiotic treatment, ozone treatment induces release of smaller amounts of endotoxin into milk and does not lead to iatrogenic endotoxin shock, which is a negative effect of antibiotic treatment [12]; our in vitro results support this study.…”

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confidence: 99%

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Comparison of the Amounts of Endotoxin Released from Escherichia coli after Exposure to Antibiotics and Ozone: an In Vitro Evaluation

Shinozuka

Uematsu

Takagi

et al. 2008

The Journal of Veterinary Medical Science

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ABSTRACT. Antibiotic therapy administered for treatment of gram-negative bacterial infections can exert a negative effect in the form of endotoxin shock. Therefore, a sterilization method that releases little endotoxin is required. This in vitro study aimed to compare the amounts of endotoxin released from Escherichia coli exposed to antibiotics (aminobenzylpenicillin, kanamycin, oxytetracycline, sulfadimethoxine and enrofloxacin) or ozone. The bacterial growth and amount of endotoxin released were measured at specific time points. Compared with antibiotic treatment, ozone sterilization induced release of smaller amounts of endotoxin from the bacteria. Moreover, no major differences were observed when ozone was used against the purified endotoxin. We conclude that compared with antibiotic treatment, ozone sterilization may release smaller amounts of endotoxin. KEY WORDS: Escherichia coli, endotoxin release, ozone.

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confidence: 99%

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confidence: 99%

Comparison of the Amounts of Endotoxin Released from Escherichia coli after Exposure to Antibiotics and Ozone: an In Vitro Evaluation

Shinozuka

Uematsu

Takagi

et al. 2008

The Journal of Veterinary Medical Science

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“…It is well recognized that ozone has sterilization capabilities and is applied in various fields [17]. It is being increasingly used as a treatment tool in mastitis [9], especially for the treatment of coliform mastitis, where intramammary application of ozone gas is used due to its high cure rate. It was reported that treatment with ozone released fewer endotoxins in the milk than treatment with antibiotics; further, no iatrogenic endotoxic shock occurred as an adverse effect, unlike that in the case of antibiotic treatment [10].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Efficacy of Mammary Irrigation Regimen in Dairy Cattle Diagnosed with Acute Coliform Mastitis

Shinozuka

Hirata²,

Ishibashi³

et al. 2009

The Journal of Veterinary Medical Science

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ABSTRACT. The objective of this field study was to determine the therapeutic efficacy of mammary irrigation for the treatment of dairy cattle diagnosed with acute coliform mastitis caused by gram-negative bacteria. Additionally, the effects of different mammary irrigation regimen fluids such as ozone water and normal saline were compared. Dairy cattle clinically diagnosed with acute coliform mastitis (n=57) were enrolled in the study, randomly assigned to 1 of 3 groups, and received the following treatments: systemic antibiotic administration (SAA group; n=40), mammary irrigation regimen (MIR group; n=10), and both treatments (MIX group; n=7). Significant antipyretic effects, as assessed by rectal temperature measurement, were observed in the MIX and MIR groups. Although 2 irrigating fluids were used, namely, ozone water and normal saline, no significant difference was observed between the 2 groups. Fourteen days after the onset of the treatments, the milk yield recovery rate in MIR group tended to be higher (p=0.06) than that in the SAA group. Additionally, after 30 days of treatment, the MIR group cows demonstrated significantly higher successful recovery rates (p<0.05) than the SAA group cows. These results indicate that mammary irrigation with normal saline is an effective treatment for acute coliform mastitis in dairy cattle.

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“…The therapeutic effects of ozone therapy could be attributable to increase in leukocytic function and increased respiratory burst. Ozone therapy can be preferred over antibiotic therapy in treating clinical mastitis as no milk withdrawal time is required with ozone therapy (Ogata & Nagahata, 2000). However, it is not clear whether ozone functions by killing the pathogen or by improving the host defence mechanism.…”

Section: Clinical Mastitis In Maresmentioning

confidence: 99%

An overview of ozone therapy in equine- an emerging healthcare solution

Bhatt¹,

Bhat²,

Dhama³

et al. 2016

JEBAS

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The significance of ozone therapy has been increasingly realised in recent times particularly in equine medicine. The beneficial effects of ozone therapy are basically engendered by the mild oxidative stress it creates upon interacting with the extra-cellular and intracellular components. However therapeutic benefits of treatment could be obtained only when it is used within the therapeutic window. Higher doses may be counterproductive and lower doses ineffective. It is now well proved that it up regulates the antioxidant system of the patient and may provide relief from many chronic degenerative diseases upon prolonged use. Ozone therapy has shown encouraging results in the treatment of wide spectrum of diseases and disorders in equines including bacterial and viral infections. Obvious benefits of ozone therapy have been reported in Equine infectious anemia, chlamydial abortions, lymphomas and equine ehrlichiosis. This article provides an insight into the mechanism of action involved in ozone therapy and reviews various conditions which could be treated with the use of ozone therapy in equines.

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Intramammary Application of Ozone Therapy to Acute Clinical Mastitis in Dairy Cows.

Cited by 54 publications

References 12 publications

Comparison of the Amounts of Endotoxin Released from Escherichia coli after Exposure to Antibiotics and Ozone: an In Vitro Evaluation

Comparison of the Amounts of Endotoxin Released from Escherichia coli after Exposure to Antibiotics and Ozone: an In Vitro Evaluation

Therapeutic Efficacy of Mammary Irrigation Regimen in Dairy Cattle Diagnosed with Acute Coliform Mastitis

An overview of ozone therapy in equine- an emerging healthcare solution

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