Intramedullary anaplastic oligodendroglioma in a child

Nam, Do‐Hyun; Cho, Byung-Kyu; Kim, Yeon-Mee; G., Je; Wang, Kyu-Chang

doi:10.1007/s003810050194

Cited by 25 publications

(31 citation statements)

References 9 publications

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“…Diagnosis of this disease are difficult to distinguish from other gliomas by MRI because these findings can find in spinal astrocytoma and ependymoma [20]. However, microcalcification is important finding, which mentioned oligodendroglioma similar to intracranial oligodendroglioma [11,16]. Regarding to histology, Most of the tumors are oligodendroglioma WHO grade 2.…”

Section: Discussionmentioning

confidence: 98%

“…Common spinal features on MRI's were isointense in T1-weighted images and hyperintense in T2-weighted images and heterogenous enhancement in Gadolinium-enhanced sagittal T1-weighted images [7,12,[16][17][18][19]. Uncommon findings might be found as an adjacent cystic component [11][12][13], microhemorrhage [4,16,19]. Diagnosis of this disease are difficult to distinguish from other gliomas by MRI because these findings can find in spinal astrocytoma and ependymoma [20].…”

Section: Discussionmentioning

confidence: 99%

“…Oligodendrogliomas are one of the primary brain tumors usually occurring in the cerebral hemispheres while these tumors of the spinal cord are rare. To the authors' knowledge, only 53 cases have been reported in literature [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

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Primary spinal cord oligodendroglioma: a case report and review of the literature

Tunthanathip

Oearsakul

2016

Chin Neurosurg Jl

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Background: Primary spinal cord oligodendroglioma is extremely rare. In an extensive review of this disease, 53 cases were reported. Furthermore, the authors summarize the characteristics of the primary spinal cord oligodendroglioma; chronological presentation , neurological imaging, treatment and the outcome obtained in the present case as well as review the literature. Case Presentation: A 46-year-old male who had progressive neck pain for a year. Magnetic resonance imaging showed an intramedullary mass from level C2 to T4. A radical resection was performed. Histology revealed oligodendroglioma. Thereafter, the patient was treated with adjuvant radiotherapy. A year later, tumor developed recurrence. The patinet died in 3 years and 6 months. Conclusions: The available data of this disease was limited. Base on 11 published papers and the present case, surgical resection is the treatment of choice although recurrence of the tumor tends to occur after partial resection with or without radiotherapy. From the literature, the management of the recurrent disease is still surgery. Moreover, Temozolomide may be an advantage in recurrent situations.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Primary spinal cord oligodendroglioma: a case report and review of the literature

Tunthanathip

Oearsakul

2016

Chin Neurosurg Jl

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“…Even in humans spinal oligodendrogliomas are described as rare, and most cases have arisen in children [2,8,14]. Radiation therapy is considered to be effective for this tumor, but many cases have a poor clinical prognosis.…”

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confidence: 99%

“…Paraffin sections were stained with hematoxylin and eosin (HE), and some selected sections of the spinal following antibodies were used as primary antibodies; rabbit antisera against human glial fibrillary acidic protein (GFAP, Typically oligodendroglioma forms soft gelatinous mass, occasionally containing cystic spaces and leptomeningial or ventricular extension is quite common [2,8,14]. Histopathologically, this tumor is characterized by a honeycomb appearance formed by accumulation of tumor cells with artifactualy swollen clear cytoplasm and central nuclei [9,12,13].…”

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confidence: 99%

Spinal Oligodendroglioma with Diffuse Arachnoidal Dissemination in a Japanese Black Heifer.

Uchida

Muranaka

Murakami

et al. 1999

The Journal of Veterinary Medical Science

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ABSTRACT. A gelatinous focus with cystic spaces, was found in the posterior funiculus of the 2nd to 3rd lumbar levels of the spinal cord of a Japanese Black heifer, 2 years old, with clinical signs of severe dysstasia. Histopathological examination revealed that the spinal lesion consisted of multifocal and diffuse proliferation of round cells with abundant vacuolar cytoplasm and hyperchromatic nuclei. In the lesions there was a number of cystic spaces containing aggregates of small round cells. The neoplastic foci showed a honeycomb structure divided by thin blood vessels, representing typical lesions of oligodendroglioma. Diffuse and multifocal proliferation of these round cells were also recognized in the subarachnoidal space in the sacral spinal cord. Immunohistochemically, the proliferating round cells were negative for glial fibrillary acidic protein. Based on these morphological features, the case was diagnosed as lumbar spinal oligodendroglioma with diffuse arachnoidal dissemination.-KEY WORDS: bovine, oligodendroglioma, spinal cord.J. Vet. Med. Sci. 61(12): 1323-1326, 1999 cord were also stained with Luxol fast blue (LFB), Masson's trichrome, Watanabe's silver impregnation, and alcian blue (pH 2.5). Histopathological examination revealed that the lumbar spinal lesion consisted of multifocal and diffuse proliferation of neoplastic cells with cystic spaces (Fig. 2). The tumor mass was located mainly in the white matter, and the posterior funiculus were almost totally replaced by the proliferating tumor cells and cystic places. The neoplastic foci showed a honeycomb structure with solid proliferation of round cells, representing the typical appearance of oligodendroglioma (Fig. 3). Most neoplastic cells were round in shape with abundant clear cytoplasm and hyperchromatic central nuclei. The presence of cytoplasmic processes was not confirmed. In the tumor there were a number of blood vessels with thin vascular walls, while the endothelial cells did not show apparent hyperplastic or proliferative changes. There were also a few of well differentiated astrocytes with well defined eosinophilic cytoplasmic processes in the neoplastic foci.In contrast, at the periphery of the neoplastic foci, diffuse proliferation of these astrocytes was prominent. Within the cystic spaces, there were aggregates of small number of small round cells mimicking lymphocytes, with small hyperchromatic round nuclei and scanty cytoplasm. Mitoses of the neoplastic cells were extremely rare. The neoplastic cells invaded the leptomeninges, and the subarachnoidal space was filled by a proliferation of these cells. Diffuse and multifocal proliferation of the round cells and lymphocyte-like small round cells, were also seen in the subarachnoidal space in the 2nd and 3rd levels of the sacral spinal cord (Fig. 4). In this area, some foci consisted of aggregates of neoplastic cells, and some areas showed an organoid structure made up of tumor cells, a few astrocytes and their cytoplasmic processes (Fig. 5). Besides the spinal cord there was no ...

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