Intramedullary Melanotic Schwannoma

Hoover, Jason M.; Bledsoe, Jonathan M.; Giannini, Caterina; Krauss, William E.

doi:10.4081/rt.2012.e3

Cited by 40 publications

(51 citation statements)

References 15 publications

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“…1 PMSs are mainly considered a manifestation of CC because approximately > 50% of patients with PMS are affected by CC. 5,6,23,[29][30][31][32] Among the intracranial cases, NPMS represents the main histologic pattern, accounting for 13 of the 18 reported cases. Histologic features do not necessarily indicate a benign outcome.…”

Section: Discussionmentioning

confidence: 99%

Intracranial Melanotic Schwannomas

Spina

Gagliardi

Boari

et al. 2015

J Neurol Surg A Cent Eur Neurosurg

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Radical surgical resection is considered the treatment of choice for MS, but treatment guidelines still do not exist. Radiotherapy seems to play an important role in reducing the risk of recurrence in the case of subtotal tumor resection. Despite the reported encouraging results, only anecdotal data are available in the pertinent literature. Future studies should focus on the role of radiotherapy as adjuvant treatment when radical surgical excision cannot be achieved.

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Section: Discussionmentioning

confidence: 99%

Intracranial Melanotic Schwannomas

Spina

Gagliardi

Boari

et al. 2015

J Neurol Surg A Cent Eur Neurosurg

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“…[1][2][3][4][5][6][7][8] We found a mean age of about 50 years old, the masculine gender being present in slightly more than half of the cases reviewed. The thoracic level was the most affected, with prevalence of extramedullary location (eight of the eleven reported cases), as well as in our patient, in which we found the development of extramedullary and intradural injury.…”

Section: Discussionmentioning

confidence: 60%

“…The positivity for HMB-45 and Melan-A is an unexpected finding, given that these antibodies are considered relatively specific for the diagnosis of malignant melanoma. 10 Reports indicate that in 10% of cases melanocytic schwannomas are malignant tumors, 1,4,7 suggesting that the presence of melanocytic Schwann cells could predispose to malignant transformation in some patients. Regarding their recurrence potential, we found in the literature rates ranging from 18.2% 6 to 24%, 7 being almost always related to incomplete resections.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding their recurrence potential, we found in the literature rates ranging from 18.2% 6 to 24%, 7 being almost always related to incomplete resections. [1][2][3][4]7 Moreover, studies have shown that among patients who were followed for more than five years, only slightly more than half were disease free at the end of follow-up, suggesting that long term monitoring is necessary to assess tumor recurrence and risk of metastasis. 10 …”

Section: Discussionmentioning

confidence: 99%

“…2,3 Magnetic resonance imaging (MRI) is the most commonly used image diagnosis test, revealing hyperintense T1 and hypointense T2 images, whereas in schwannomas of the non-melanocytic type, the immage pattern is the opposite. [2][3][4] In the literature, we found few cases of melanocytic type schwannoma in the spine, the largest series consists of five cases. 2 Thus, based on its extreme rarity, this paper aims to report a case of melanocytic schwannoma of the lumbar spine and conduce a brief literature review.…”

Section: Introductionmentioning

confidence: 99%

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Melanotic schwannoma of the lumbar spine: a case report and literature review

et al. 2015

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Schwannomas are benign tumors, usually solitary, encapsulated, slow-growing, which have their origin in differentiated neoplastic Schwann cells with extramedullary intradural usual development related to nerve roots. The melanotic schwannoma is a variant of these tumors whose location in almost one third of cases is on the posterior spinal nerve root, with a nonspecific clinical presentation. Magnetic resonance imaging is the most widely used test for the diagnosis, revealing hyperintense T1-weighted sequences and hypointense T2-weighted sequences. Diagnostic confirmation is obtained by histological and immunohistochemical studies, in which there is intense cytoplasmatic pigmentation. There are two distinct types of melanotic schwannomas: sporadic and psammomatous, the latter related to the called Carney complex, a form of multiple endocrine neoplasm with familiar character. In literature we found few cases of these neoplasms, the largest series consisting of five cases. The objective of this study is to report a rare case of melanotic schwannoma of the lumbar spine of the sporadic type of extramedullary location. We also present a brief review of the literature containing the main characteristics of the tumor, including its different forms, differential diagnoses, data from histological and immunohistochemical studies as well as the currently recommended approach in order to contribute to a better understanding of this neoplasm.Keywords: Spine; Spinal neoplasms; Schwann Cells; Manipulation, spinal. RESUMO Os schwannomas são tumores benignos, geralmente solitários, encapsulados e de crescimento lento, que têm sua origem nas células de Schwann neoplásicas diferenciadas, com desenvolvimento habitual extramedular intradural relacionado com as raízes nervosas. O schwannoma melanocítico é uma variante dessas neoplasias cuja localização em quase um terço dos casos está na raiz nervosa posterior

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Melanotic schwannoma: an 11-year case series

et al. 2015

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Melanotic or melanocytic schwannoma is a rare tumour usually involving spinal nerve roots but can also present at other anatomical locations. Although there are less than 200 cases reported, melanotic schwannomas can have distinctive imaging features but there is limited recent literature on its often characteristic radiological appearances. Recent publication of the largest case series thus far has suggested melanotic schwannoma to be a separate entity to other schwannomata and that its reclassification to a malignant lesion be under consideration. We present a case series over an 11-year period to highlight salient imaging features with reference to the current concerns regarding its malignant potential.

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Intramedullary Melanotic Schwannoma

Cited by 40 publications

References 15 publications

Intracranial Melanotic Schwannomas

Intracranial Melanotic Schwannomas

Melanotic schwannoma of the lumbar spine: a case report and literature review

Melanotic schwannoma: an 11-year case series

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