Intrameningioma metastasis: A case-based literature review

Papadakis, Benjamin Konstantinos; Vorrias, Eleftherios; Bräutigam, Konstantin; Chochlidakis, Nikolaos; Koutsopoulos, Anastasios; Mavroudis, Dimitriοs; Vakis, Antonis; Tsitsipanis, Christos

doi:10.1016/j.jocn.2021.08.028

Cited by 8 publications

(18 citation statements)

References 35 publications

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“… 30 In people, meningioma represents the most frequent recipient tumour with TTM phenomenon affecting the CNS. 31 This higher incidence could be explained by various factors. Meningiomas are characterised by their rich vascularisation, low metabolic activity, hormonal factor expression and contain cell–cell adhesion molecules.…”

Section: Discussionmentioning

confidence: 98%

“…All these characteristics may provide an appropriate environment for the development of metastasis. 28 , 31 In humans, breast and lung carcinomas seem to be the most common metastases-originating tumours participating in the TTM phenomenon. 28 , 32 The diagnosis of TTM is based on several criteria: (1) more than one primary tumour must exist; (2) the recipient tumour must be a true neoplasm; (3) the metastatic neoplasm should show established growth in the recipient tumour; and (4) tumours that have metastasised to the lymph nodes where malignant tumours already exist are excluded.…”

Section: Discussionmentioning

confidence: 99%

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Cerebral meningioma associated with extensive calvarium osteolysis and presumed intratumoral carcinoma metastasis in a cat

Dussaux

Gomes

Hurion

et al. 2022

Journal of Feline Medicine and Surgery Open Reports

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Case summary A 10-year-old male neutered domestic shorthair cat presented with a 3-month history of weight loss, dysorexia and lethargy. Neurological examination revealed decreased mentation, absent menace response bilaterally and proprioceptive deficits affecting all four limbs; these findings were consistent with a forebrain disorder. Brain CT revealed an extensive asymmetric permeative osteolysis destroying two-thirds of the circumference of the calvarium and involving the right frontal, parietal, temporal and occipital bones, as well as the left parietal bone. This extensive bone lysis was associated with a large ‘plaque-like’ extra-axial subdural/pachymeningeal lesion extending within the soft tissues surrounding the calvarium. The cat was humanely euthanased. Post-mortem MRI was performed, which revealed a T2-weighted (T2W) hypointense subdural lesion and a T2W hyperintense circumferential extracranial lesion lining the right calvarium and left parietal bone. Histopathological analysis on a post-mortem sample of the lesion revealed a fibroblastic subtype of meningioma. Epithelial neoplastic cells were observed scattered through the meningioma, calvarium and surrounding muscular tissues, corresponding with presumed metastatic carcinoma. Relevance and novel information To our knowledge, this is the first report of an intracranial meningioma associated with such an extensive and diffuse calvarial osteolysis in veterinary medicine. This is also the first description of presumed metastatic inclusions (adenocarcinoma in this case) inside an intracranial feline meningioma, which is a rare phenomenon known as tumour-to-tumour metastasis in human medicine.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Cerebral meningioma associated with extensive calvarium osteolysis and presumed intratumoral carcinoma metastasis in a cat

Dussaux

Gomes

Hurion

et al. 2022

Journal of Feline Medicine and Surgery Open Reports

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“…There is no apparent predilection of meningioma subtypes to increased risk of tumor-to-tumor metastasis [ 1 , 13 ]. Nonetheless, features of the metastasis may facilitate the process.…”

Section: Molecular Findingsmentioning

confidence: 99%

“…This extensive vascularity in meningiomas per se may be another factor facilitating metastasis to meningiomas. The angiogenesis and peritumoral edema may be facilitated, in part, by increased expression of vascular endothelial growth factor (VEGF) promoting vascular proliferation [ 1 , 17 ].…”

Section: Molecular Findingsmentioning

confidence: 99%

“…Approximately 5–15% of solid tumors spreading to the central nervous system metastasize to the leptomeninges. Less common, is metastasis to leptomeningeal meningiomas [ 1 , 2 , 3 ]. The biology and clinical features of these metastases is likely different from spread to the brain parenchyma per se since the leptomeninges are outside the blood–brain barrier, bathed in cerebrospinal fluid, and heavily vascularized.…”

Section: Introductionmentioning

confidence: 99%

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Metastases to Meningiomas: A Comprehensive Literature Review Including Mediating Proteins

Johnson

2022

Cancers

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Approximately 5–15% of solid tumors metastasizing to the central nervous system metastasize to the leptomeninges. Less common, is metastasis to leptomeningeal meningiomas. These are primarily carcinomas of the breast and lung. Awareness of this phenomenon is critical to the evaluation of meningiomas, especially since the metastases may be the first indication of an occult tumor elsewhere in the body. Lack of clear demarcation between the metastasis and meningioma parenchyma, as well as histological features similar to the meningioma, may hinder recognition. The mechanisms underlying metastases anchoring and spread along the leptomeninges are not established. However, several cell adhesion molecules are thought to contribute to this phenomenon. E cadherin is a cell adhesion molecule present in meningioma cells. Binding to endothelium by adhesion molecules such as ICAM, B1 integrin, P-selectin, PECAM-1, CXCL12 and SDF-1 have also been proposed as part of the mechanisms underlying breast carcinoma metastases. In addition, the leptomeninges and meningiomas express mesothelin that acts as an anchoring protein coupling with mucin-16. Consequently, metastatic tumor cell mucin and mesothelin may also facilitate the anchoring of metastases to meningiomas.

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