Intramolecular Amidation: Synthesis of Novel Thiazole‐Fused Diazepinones

Koti, R. S.; Kolavi, Gundurao; Hegde, Vinayak; Khazi, I. M.

doi:10.1080/00397910600978481

Cited by 9 publications

(1 citation statement)

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“…In the last few years, researchers have renewed interest in 3‐(thiazol‐4‐yl)coumarins [1–6] for their industrial applications as fluorescent probes and laser dyes [7], for their biological activity as pharmaceutical agents [8–10] and because they could be useful for the construction of the diazepinone ring [11]. In addition, π‐conjugated systems are known to show interesting electronic, optical, and electric properties [12].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and biological evaluation of novel conjugated coumarin‐thiazole systems

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et al. 2009

Journal of Heterocyclic Chem

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in Wiley InterScience (www.interscience.wiley.com).Seven new 2,4-disubstituted thiazoles have been synthesized by Hantzsch condensation and assayed for several biological activities for a preliminary screening. They have been fully characterized by elemental analysis, UV-Vis spectroscopy, TG-DTA, IR, and 1 H NMR as well. These structures display different pharmacological (antimicrobic activity, citotoxicity, and hMAO inhibition) and industrial properties (complete transparency in the region between 465-800 nm and high thermal stability) varying on their substituents and could be considered as good lead compounds for further developments.

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