New N1-aral-N4- (3-chloro-4-fluorophenyl)thiosemicarbazones (2a-h) and their Cu(I) complexes (3a-h) have been prepared and characterized by elemental analysis and spectral methods (IR and 1H-NMR). Thiosemicarbazones 2a-h bind to copper(I) as bidentate ligand via nitrogen and thione sulphur centers to afford 3a-h. Both ligands and their complexes are screened against Escherichia coli (National Collection of Type Culture 10418) and Staphylococcus aureus (National Collection of Type Culture 5571) to evaluate their antibacterial properties and against human virulent H37Rv strain of Mycobacterium tuberculosis for their antitubercular properties. Ligands 2d-h showed promising antibacterial activity while their Cu(I) complexes 3d-h exhibited excellent activity. The compounds 2a, 2d, 2f, 2g and their Cu(I) complexes 3a, 3d, 3f and 3g were evaluated for their antitubercular activity. It was observed that compounds 2a, 2g, 3a, 3d showed moderate activity while 3f and 3g exhibited promising antitubercular activity.

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Thiazole derivatives R 0260Vilsmeier-Haack Reaction of Substituted 2-Acetamidothiazole Derivatives and Their Antimicrobial Activity. -Vilsmeier-Haack reaction of 2-acetamidothiazole (I) having an ethoxycarbonyl group at C-4 affords unexpectedly the deacylated, N-formylated product (III). Vilsmeier-Haack formylation of thiazoles bearing 4-substituents other than the ethoxycarbonyl group gives the expected C-5 formylated products (V). All products are screened for their antimicrobial activities against two strains of bacteria and fungi. -(KOTI, R. S.; KOLAVI, G. D.; HEGDE, V. S.; KHAZI*, I. M.; Indian J.

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1-b]thiazoles and Their 5-Bromo/5-Formyl Derivatives. -Imidazo[2,1-b]thiazole derivatives of type (III), (IV), (V), and (VII) are prepared. Compounds (III) are tested for their antihelmintic activities and compounds (IV) and (VII) are tested for their antiinflammatory activities. They show moderate activity. -(KHAZI*, I. M.; KOTI, R. S.; GADAD, A. K.; MAHAJANSHETTI, C. S.; SHIVAKUMAR, Y. B.; AKKI, M. V.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 43 (2004) 2, 393-398; Dep. Stud. Chem., Karnatak Univ., Dharwad 580 003, India; Eng.) -M. Bohle 22-144