Vilsmeier—Haack Reaction of Substituted 2‐Acetamidothiazole Derivatives and Their Antimicrobial Activity.

Koti, R. S.; Kolavi, Gundurao; Hegde, Vinayak; Khazi, I. M.

doi:10.1002/chin.200650142

Cited by 3 publications

(2 citation statements)

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“…Thiazole derivatives have been reported to possess significant and diverse biological activities such as antimicrobial [3], analgesic [4], anti-inflammatory [5], antioxidant [6], anti HIV [7] and antitubercular [8,9] activities. Moreover, thiazoles are also synthetic intermediates and substructures in several biologically active compounds [10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and antimicrobial screening of thiazole based 1,3,4-oxadiazoles heterocycles

et al. 2015

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In an effort to find a new pharmacologically dynamic molecule, we report here the synthesis and in vitro antimicrobial activity of various N-(4-methyl-5-(4-((substituted phenylamino) methyl)-5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)thiazol-2-yl) benzamides. The structures of newly synthesized compounds were assigned on the bases of IR, 1 H NMR, 13 C NMR, and mass spectral data. Synthesized compounds were screened for their antibacterial and antifungal activities on gram-positive bacteria (Staphylococcus aureus and Streptococcus pyogenes), gramnegative bacteria (Escherichia coli and Pseudomonas aeruginosa) and three fungi (Candida albicans, Aspergillus niger and Aspergillus clavatus) by serial broth dilution method. Compounds 5e and 5k were associated with considerable potential antibacterial and compounds 5a and 5b antifungal activities.

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Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and antimicrobial screening of thiazole based 1,3,4-oxadiazoles heterocycles

et al. 2015

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“…Yield 49 %, M.P 172 0 C. Compounds 4b-d were prepared by this method. 37 and methyl amine (2.5 mmol) was stirred in about 5 ml of ethanol at room temperature for 7.5 h and kept for 48 hours at cold condition. The crystalline solid obtained was collected and washed with ice-cold water and dried to give the title compound (5a).…”

Section: General Procedures For the Synthesis Of Title Compounds (5a-h)mentioning

confidence: 99%

Synthesis of Novel Benzopyrone Substituted Benzimidazole Analogues as Antibacterial Agents

Som¹

2015

Int. Res. J. Pharm.

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A large variety of scientific reviews and reports are providing informations about the effectiveness of synthetic and semi synthetic analogues of benzimidazoles and benzopyrones. It was our interest to explore the novel compounds containing these two fundamental heterocycles in one structure. The present study deals with the synthesis and determination of antibacterial activity of benzopyrone substituted benzimidazole derivatives. The derivatives were synthesized in a good to moderate yields. The structural analysis for the synthesized derivatives was done by IR, 1 HNMR and Mass spectral analysis. Further the compounds were subjected for antibacterial evaluation, among them 5a, 5b, 5g and 5h showed appreciable activity against the strains used. In view of the antibacterial studies, these derivatives can be further modified and investigated for future development.

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Synthesis and antimicrobial activities of some novel thiazole compounds

Turan-Zitouni

Çavuşoğlu

Sağlık

et al. 2017

Turkish Journal of Biochemistry

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Objective: The advent of resistant pathogenic microorganisms against current antimicrobial drugs prompted scientists to investigate novel molecules with new mechanisms. In this paper, some new 2-[2-[4-(ethyl/phenyl)cyclohexylidene]hydrazinyl]-4-(4-substitutedphenyl)thiazole (2a–2o) derivatives were synthesized and studied for their antimicrobial activities. Materials and methods: The title compounds (2a–2o) were obtained via the reaction of 4-(ethyl/phenyl)cyclohexane-1-one with appropriate phenacyl bromide in ethanol at room temperature. The chemical structures of the compounds were elucidated by FT-IR, 1H-NMR, 13C-NMR, HRMS and elemental analysis. Antimicrobial activity of the compounds was measured by using broth microdilution method. Chloramphenicol and ketoconazole were used as reference drugs. Results: Among the synthesized compounds, 2-[2-(4-phenylcyclohexylidene)hydrazinyl]-4-phenylthiazole (2h) and 2-[2-(4-phenylcyclohexylidene)hydrazinyl]-4-(4-chlorophenyl)thiazole (2l) have been found to exhibit potency almost four-fold better than ketoconazole against C. albicans with MIC90 value of 1.95. Conclusion: The current study contributed to the knowledge of the antimicrobial activity of thiazole bearing compounds.

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Vilsmeier—Haack Reaction of Substituted 2‐Acetamidothiazole Derivatives and Their Antimicrobial Activity.

Cited by 3 publications

References 0 publications

Synthesis, characterization and antimicrobial screening of thiazole based 1,3,4-oxadiazoles heterocycles

Synthesis, characterization and antimicrobial screening of thiazole based 1,3,4-oxadiazoles heterocycles

Synthesis of Novel Benzopyrone Substituted Benzimidazole Analogues as Antibacterial Agents

Synthesis and antimicrobial activities of some novel thiazole compounds

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