Synthesis and Biological Activity of Some 3‐Methyl/ethoxycarbonyl‐6‐arylimidazo[2,1‐b]thiazoles and Their 5‐Bromo/5‐Formyl Derivatives.

Abstract

1-b]thiazoles and Their 5-Bromo/5-Formyl Derivatives. -Imidazo[2,1-b]thiazole derivatives of type (III), (IV), (V), and (VII) are prepared. Compounds (III) are tested for their antihelmintic activities and compounds (IV) and (VII) are tested for their antiinflammatory activities. They show moderate activity. -(KHAZI*, I. M.; KOTI, R. S.; GADAD, A. K.; MAHAJANSHETTI, C. S.; SHIVAKUMAR, Y. B.; AKKI, M. V.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 43 (2004) 2, 393-398; Dep. Stud. Chem., Karnatak Univ., Dharwad 580 003, India; Eng.) -M. Bohle 22-144

Synthesis, Spectroscopy and Crystal Structure of 2-cyclohexyl-5-formyl-6-(4-bromophenyl)imidazo[2,1-b][1,3,4]thiadiazole

“…Many imidazothiadiazole derivatives have been reported to possess diverse medicinal properties such as anthelmintic, 6 antimicrobial, 7 anti-inflammatory, antipyretic-analgesic properties 8 and many other activities of therapeutic significance. 9,10 These findings prompted us to synthesise the title compound so that it could be screened for its pharmacological activities, and to carry out its crystallographic structure elucidation. The title compound will be a good intermediate to synthesise various candidate compounds for pharmacological testing.…”