Intramural fibroma of the heart∗

Hoen, Alexis G.; Ellis, Eugene J.

doi:10.1016/0002-9149(66)90250-5

Cited by 19 publications

(3 citation statements)

References 15 publications

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“…Abnormalities of the ECG in cases of intramural fibroma include left ventricular hypertrophy and strain (Valledor et al, 1960;Parks et al, 1962;Hoen and Ellis, 1966), conduction defects (Jernstrom and Cremin, 1959;Edlund and Holmdahl, 1957), and cardiac arrhythmias (Jernstrom and Cremin, 1959). The appearance of pathological Q waves in leads over the site of the tumour has also been reported (gvejda and Tomasek, 1960;Osano et al, 1969).…”

Section: Discussionmentioning

confidence: 97%

“…One 17-month-old infant died shortly after complete removal of the tumour (Wilson et al, 1965). In others the extent of the tumour revealed at thoracotomy precluded removal, but, despite this, some of these patients had remained well for over a year following operation (Bickford, Egan, and Bryce, 1956;Edlund and Holmdahl, 1957;Hoen and Ellis, 1966).…”

Section: Discussionmentioning

confidence: 99%

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Intramural fibroma of the left ventricle

Hall

1971

Thorax

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A case of left ventricular fibroma in a symptomless 17-year-old girl is described. The tumour was extensive and after its removal inadequate left ventricular function resulted in death at operation. The role of surgical treatment is discussed.Primary tumours of the heart are rare (Prichard, 1951;Hudson, 1965;Heath, 1968) and particularly uncommon is the intramural ventricular fibroma; only 36 cases had been reported up to 1967 (Geha, Weidman, Soule, and McGoon, 1967). Most of these intramural fibromas were found in infants and young children at either necropsy or thoracotomy, but over the past 15 years the diagnosis has been made before operation and in a few patients successful surgical removal has been accomplished (Parks, Adams, and Longmire, 1962;Geha et al., 1967;Bjork, Dahlgren, Rudhe, Zetterqvist, 1967;Kay et al., 1968;Osano et al., 1969).Because of the rarity of these tumours Freeman, Geer, Randall, and Palfrey (1963) suggested that cases should be reported in order to increase knowledge of their natural history, diagnosis, and treatment. The case described here is that of a young girl with a large intramural fibroma of the left ventricle, diagnosed preoperatively, who died at operation. CASE REPORTThe patient, a 17-year-old girl, was referred to the Department of Cardiology, Royal Infirmary, Edinburgh, by her general practitioner who had detected a precordial systolic murmur at routine medical examination.She was asymptomatic and apart from common childhood illnesses her previous health had been excellent. On specific enquiry, however, she had noticed occasional 'missed beats' during the preceding few months.She was of average build with sinus arrhythmia and a systemic blood pressure of 115/60 mmHg. The jugular venous pulse was normal. There was no cardiomegaly and no thrill, but systolic pulsation was palpable at the upper left sternal edge. Heart sounds were normal with inspiratory splitting of the second heart sound and no accentuation of the pulmonary component. A short grade 2/6 mid-systolic murmur was heard in the pulmonary area but was not audible in the axillae or over the back. No ejection sound, diastolic murmur or other abnormal physical sign was detected.The electrocardiogram ( Fig. la and b) showed sinus arrhythmia with occasional ventricular extrasystoles and symmetrical inversion of the T waves in the high anterolateral leads. Her chest radiograph (Fig. 2) showed a localized bulge on the upper left heart border. Pulmonary arteries and pulmonary vascularity were normal. No calcification was detected at fluoroscopy. The full blood picture, blood urea, electrolytes, and plasma proteins were normal.At cardiac catheterization pressures and oxygen saturations on the right and left sides of the heart were normal. Cine-angiography, performed from the right and left ventricles, demonstrated a large mass encroaching on the outflow tract of both ventricles and displacing the interventricular septum to the right. The left atrium was also distorted and the left atrial appendage was not filled with c...

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Intramural fibroma of the left ventricle

Hall

1971

Thorax

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“…There are three recent good reviews of the subject of fibroma of the heart, including lists of reported cases and the postulated causes of death. [3][4][5] It may be useful to consider briefly some possible mechanisms of lethal electrical instability of the heart in this patient. Although there was no history igure 1 These two photomicrographs compare the His bundle described in the present report with a normal one from an adult of similar age (both sections prepared with Goldner trichrome stain).…”

Section: Discussionmentioning

confidence: 99%

De Subitaneis Mortibus

1973

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Necropsy studies of sudden death should always include examination of the conduction system of the heart but seldom do. This case is an example of sudden unexpected death in which there was a fibroma compressing the His bundle. Almost by definition it will be necessary to reconstruct probable clinical events retrospectively in such cases and several such considerations are made here. By studying individual examples and appropriate groups of cases in this way, it should be possible to reduce the number of "unexplained" cases, to formulate reasonable hypotheses for prospective examination, and ultimately to devise means of preventing some of these deaths.

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Primary Solid Tumors of the Heart

Urba¹,

Longo²

1986

Cancer and the Heart

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Intramural fibroma of the heart∗

Cited by 19 publications

References 15 publications

Intramural fibroma of the left ventricle

Intramural fibroma of the left ventricle

De Subitaneis Mortibus

Primary Solid Tumors of the Heart

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