Intramural Metastases of Rectum From Carcinosarcoma (Malignant Müllerian Mixed Tumor) of Uterine Cervix

Wu, Yu-Chin; Yang, Chun-Fan; Hsu, Chang Hu; Hsieh, T’sang‐T’ang

doi:10.1097/rlu.0b013e318266d4bd

Cited by 9 publications

(5 citation statements)

References 13 publications

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“…Carcinosarcoma usually occurs in postmenopausal women; the incidence of carcinosarcoma in premenopausal women is exceedingly rare. A 25 years old woman with CCS has been reported [ 4 – 6 ]. The typical clinical symptoms are vaginal bleeding; other symptoms include vaginal discharge, abdominal mass, abdominal pain, or no obvious symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…Unlike ovarian carcinosarcoma [ 5 ], the majority of UCS and CCS are at an early stage without peritoneal metastasis. However, even though carcinosarcoma is in stage I, the 5-year survival rate is still less than 50% [ 6 ]. It was previously reported that invasion depth and clinical stage were independent risk factors for prognosis [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

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Clinical and imaging features of carcinosarcoma of the uterus and cervix

Huang

Xue

et al. 2021

Insights Imaging

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Aim The purpose of our study was to analyze the clinical and imaging features of uterine carcinosarcoma (UCS) and cervical carcinosarcoma (CCS), and to explore the diagnostic and staging accuracy of computed tomography (CT) and magnetic resonance imaging (MRI) examinations. Methods 41 patients including 37 with UCS and 4 with CCS from July 2011 to September 2020 were enrolled in the study. Of the 37 UCS cases, 7 had CT images, 27 had MRI images, and 3 had both CT and MRI images. The Clinical data, CT or MRI imaging findings were analyzed. Diagnosis and staging accuracy of CT and MRI images were also analyzed. Results Carcinosarcoma usually occurs in postmenopausal women (40/41), with the typical clinical symptom being vaginal bleeding (33/41). The CA125 degree was significantly different between the two invasion depth groups (p = 0.011). Most uterine carcinosarcomas showed unclear boundaries, uneven density, low or equal signal on T1WI, high or mixed signal on T2WI, uneven high signal on diffusion-weighted image (DWI), and mild enhancement. The diagnostic accuracies of CT and MRI for carcinosarcoma were 0% and 3.33%, respectively. The diagnostic accuracy for malignant tumors on CT and MRI was 50% and 83.33%, respectively. Conclusions Carcinosarcoma lesions presented with huge mass filling in the cavity, and some presented with small polypoid lesions or endometrial thickening. Evaluation of lymph node metastasis is a significant challenge for imaging staging.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical and imaging features of carcinosarcoma of the uterus and cervix

Huang

Xue

et al. 2021

Insights Imaging

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“…[13][14][15]31,33 F-FDG PET/CT scans performed in 12 previous studies (Table 3). The various anatomical sites were the uterus (six studies, median SUVmax: 10.13), 25,[46][47][48][49][50] prostate (one study, SUVmax: 9.70), 23 liver (one study, SUVmax: 17.10), 24 stomach (one study, SUVmax: 11.90), 51 pulmonary system (two studies, median SUVmax: 10.47), 52,53 and hypopharynx (one study, SUVmax: 8.06). 15 Furthermore, the median SUVmax of all of these studies was 11.23, similar to the value of 10.30 reported in our study.…”

Section: Discussionmentioning

confidence: 99%

True hypopharyngeal carcinosarcoma: a case report and literature review

et al. 2018

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ObjectiveCarcinosarcoma consists of carcinomatous and sarcomatous tissues and is an aggressive malignant tumor. It is rarely reported in the hypopharynx.MethodsA 72-year-old man presented with dysphagia and dyspnea. Laryngoscopy, computed tomography (CT), and 18F-fluorodeoxyglucose positron emission tomography/CT (18F-FDG PET/CT) showed a neoplasm on the left posterior hypopharyngeal wall. The patient underwent bilateral neck dissection and excision of the hypopharyngeal cancer followed by postoperative radiation therapy.ResultsImmunohistochemistry revealed carcinomatous cells with membrane positivity for cytokeratin, glucose transporter-1 (GLUT-1), phosphoinositide-3 kinase (PI3K), hypoxia-inducible factor-1α (HIF-1α), and hexokinase-II as well as sarcomatous cells with membrane positivity for smooth muscle actin, GLUT-1, HIF-1α, and PI3K. Histopathology and immunohistochemistry revealed a true carcinosarcoma of the hypopharynx (pT3N0M0, Stage III).ConclusionsThorough immunohistochemistry is required for a correct diagnosis of hypopharyngeal carcinosarcoma. 18F-FDG PET/CT may help to distinguish hypopharyngeal carcinosarcoma from benign tumors.

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“…26,29,31 PET-CT is sometimes available to assure extrauterine metastasis in patients with CCS. 11,32,33 The gold standard of diagnosing CCS is pathological examination. As the accessibility of the uterine cervix, cervical biopsy examination is easy performed and can bring a definite diagnosis of CCS.…”

Section: Diagnosismentioning

confidence: 99%

“… 26 , 29 , 31 PET-CT is sometimes available to assure extrauterine metastasis in patients with CCS. 11 , 32 , 33 …”

Section: Diagnosismentioning

confidence: 99%

Cervical Carcinosarcoma: Current Understanding on Pathogenesis, Diagnosis, Management and Future Perspectives

Shu

Zhou

Wei

et al. 2021

Clin Med Insights Oncol

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Cervical carcinosarcoma (CCS) is a rare aggressive tumor which was referred to as a sarcoma initially with its morbidity less than 1% of all cervical cancers. Four theories have been proposed for the pathogenesis of CCS. The “metaplastic theory,” also called “monoclonal theory,” has been widely accepted so far. The most common clinical symptom of CCS is abnormal vaginal bleeding. CCS is much less common than the counterparts in uterine corpus and usually confused with uterine carcinosarcoma (UCS) or common cervical cancer. The management for CCS has been mainly extrapolated from studies of UCS or cervical cancers. However, CCS has its special anatomical position and biological behaviors and is usually diagnosed at an early stage than UCS. Currently, there is no consensus on the survival, management and prognosis factors of CCS. We reviewed and summarized the literatures regarding to the epidemiology, clinical presentations, pathogenesis, diagnosis and treatment of CCS for providing clinicians with comprehensive information to diagnose and treat this malignancy.

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Intramural Metastases of Rectum From Carcinosarcoma (Malignant Müllerian Mixed Tumor) of Uterine Cervix

Cited by 9 publications

References 13 publications

Clinical and imaging features of carcinosarcoma of the uterus and cervix

Clinical and imaging features of carcinosarcoma of the uterus and cervix

True hypopharyngeal carcinosarcoma: a case report and literature review

Cervical Carcinosarcoma: Current Understanding on Pathogenesis, Diagnosis, Management and Future Perspectives

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