Lipomas are benign mesenchymal neoplasms originating from mature adipose tissue, and frequently in clinical evaluation, they present as an increase in nodular volume, with a sessile or pedunculated base, smooth surface, and smooth consistency, asymptomatic and slow growth. Its color varies from yellowish to pink depending on the depth found in the tissues. In the oral cavity, its appearance is classified as rare. When present, their occurrence is greater in the cheek mucosa, lip, tongue, buccal sulcus, and buccal floor. The objective of this article is to report the clinical case of two lipomas in the mandibular region, where an excisional biopsy was performed, with different surgical modalities, but with effective treatment in both cases.