1996
DOI: 10.1016/s0026-0495(96)90260-7
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Intramuscular triglyceride and muscle insulin sensitivity: Evidence for a relationship in nondiabetic subjects

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Cited by 355 publications
(266 citation statements)
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“…IMTG is best correlated with an individual's degree of insulin resistance, regardless of BMI [6][7][8]. No differences in IMTG were observed in LGI or HGI, indicating that hyperglycaemia-hyperinsulinaemia is not sufficient to elicit higher levels of IMTG in myotubes of post-diabetes mellitus participants.…”
Section: Discussionmentioning
confidence: 89%
See 1 more Smart Citation
“…IMTG is best correlated with an individual's degree of insulin resistance, regardless of BMI [6][7][8]. No differences in IMTG were observed in LGI or HGI, indicating that hyperglycaemia-hyperinsulinaemia is not sufficient to elicit higher levels of IMTG in myotubes of post-diabetes mellitus participants.…”
Section: Discussionmentioning
confidence: 89%
“…The molecular mechanisms responsible for the progression of insulin resistance are still poorly understood. Ectopic accumulation of lipid in skeletal muscle (intramuscular triacylglycerol [IMTG]) is associated with obesity and highly correlated with the development of insulin resistance [6][7][8]. However, the observation that lean, insulin-sensitive endurance-trained athletes have high levels of IMTG has led to the hypothesis that altered or incomplete lipid metabolism may be an important factor in the progression of insulin resistance (reviewed by van Loon and Goodpaster [9]).…”
Section: Introductionmentioning
confidence: 99%
“…The expression levels were calculated and expressed as the mean ratio to β-actin expression ± SEM. n=5 and n=4 for transgenic and control rabbits respectively though we cannot exclude the possibility that transgenic rabbits may have (locally) hepatic insulin resistance associated with the fatty liver [30,31,32], overall effect of LPL overexpression on insulin sensitivity was apparently beneficial. These findings in transgenic rabbits contrast with the results in transgenic mice that showed insulin resistance accompanied by accumulation of TG in their skeletal muscle [16] or liver [4].…”
Section: Discussionmentioning
confidence: 96%
“…Furthermore, a combined excess in energy intake and impaired adipogenesis could be manifested as enlarged fat cells and NEFA spill-over from adipose tissue to muscle and liver, where they accumulate as ectopic triacylglycerols. This is found in obese subjects and subjects with type 2 diabetes [10,42] and is associated with reduced insulin sensitivity [43][44][45][46].…”
Section: Discussionmentioning
confidence: 99%