Intramuscular versus Subcutaneous Administration of Iron Dextran in Suckling Piglets

Svoboda, Martin; Drábek, J.

doi:10.2754/avb200776s8s011

Cited by 15 publications

(16 citation statements)

References 9 publications

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“…Obviously, injection of high amounts of iron rectifies neonatal IDA in pigs as exemplified in this study and many others [10], [11], [12], [13]. However, it is accompanied by the risk of excessive hepcidin synthesis, which in turn may impair both the utilization of supplemental iron deposited in RES macrophages and the absorption of dietary iron.…”

Section: Resultsmentioning

confidence: 66%

“…Moreover, the molecular machinery responsible for iron absorption in newborn piglets is not fully developed, and this may explain a reduced responsiveness of these animals to oral iron therapy [8], [9]. Consequently, the use of parenteral injection of exogenous iron to prevent deepening iron deficiency in suckling piglets has been well documented and is obligatory in pig breeding [10], [11], [12]. Various iron supplementation strategies (in terms of time and route of iron administration as well as the amount and the form of supplemental iron) have been tested and many of them proved to be beneficial in correcting IDA in newborn piglets as evaluated by measuring their RBC indices and serum iron status [10], [11], [12], [13], [14], [15].…”

Section: Introductionmentioning

confidence: 99%

“…The intramuscular injection of large amount of iron dextran to suckling piglets is a relatively simple therapy, which in general, efficiently corrects iron deficiency anemia (IDA), widely occurring in pig neonates, and therefore is routine practice in pig breeding [10], [11], [12]. We have recently demonstrated that excessive loading of piglets with iron dextran induces hepcidin expression at the mRNA level in the liver, and may perturbate the utilization of iron released from this compound by blocking ferroportin [10], [20].…”

Section: Introductionmentioning

confidence: 99%

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Iron Supplementation in Suckling Piglets: How to Correct Iron Deficiency Anemia without Affecting Plasma Hepcidin Levels

et al. 2013

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The aim of the study was to establish an optimized protocol of iron dextran administration to pig neonates, which better meets the iron demand for erythropoiesis. Here, we monitored development of red blood cell indices, plasma iron parameters during a 28-day period after birth (till the weaning), following intramuscular administration of different concentrations of iron dextran to suckling piglets. To better assess the iron status we developed a novel mass spectrometry assay to quantify pig plasma levels of the iron-regulatory peptide hormone hepcidin-25. This hormone is predominantly secreted by the liver and acts as a negative regulator of iron absorption and reutilization. The routinely used protocol with high amount of iron resulted in the recovery of piglets from iron deficiency but also in strongly elevated plasma hepcidin-25 levels. A similar protocol with reduced amounts of iron improved hematological status of piglets to the same level while plasma hepcidin-25 levels remained low. These data show that plasma hepcidin-25 levels can guide optimal dosing of iron treatment and pave the way for mixed supplementation of piglets starting with intramuscular injection of iron dextran followed by dietary supplementation, which could be efficient under condition of very low plasma hepcidin-25 level.

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Section: Resultsmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Iron Supplementation in Suckling Piglets: How to Correct Iron Deficiency Anemia without Affecting Plasma Hepcidin Levels

et al. 2013

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“…Another option is subcutaneous (s.c.) administration. Svoboda and Drabek (2007) found that it has the same efficacy as i.m. injection.…”

Section: Administration Techniquementioning

confidence: 93%

Parenteral iron administration in suckling piglets – a review

2017

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Parenteral iron administration has been a common practice for the prevention of iron deficiency in newborn piglets. The efficacy and safety of this method require reexamination due to the introduction of new genetic lines and management changes in swine production. The aim of this article was to review current knowledge on this method of anaemia prevention in piglets. Iron requirements, iron sources, and the mode of action, dosage, and negative effects of iron dextran injection are discussed. The paper also reviews methods for evaluating the efficacy of iron administration in piglets.Iron dextran, oxidative stress, heamoglobin, haematocrit

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“…In order to ensure that a selected therapy has a positive effect on growth performance and production parameters several studies were conducted [9,12,18,19,20,21,22,23,24,25,26,27,28]. Svoboda and Drabek (2004) report that 3-day--old piglets injected with iron showed significant increase in haematological parameters (Hb, MCV, MCH, MCHC, PI) on the 21st day of life, whereas piglets from no treatment group developed hypochromic anaemia [29]. In the latter group iron deficiency resulted also in considerably lower body weights on the 21st day of life compared to treated groups.…”

Section: Introductionmentioning

confidence: 99%

Can iron work for pigs as a booster?

Urbaniak

Spyrka

Rząsa

2017

Advances in Cell Biology

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Iron deficiency is a common health problem in mammals, especially in growing piglets hence iron administration to suckling piglets is a routine practice in swine production. A total number of 160 weaners were allotted to two experimental groups according to body weight (I -cachectic underweight piglets; II -piglets with appropriate weaning body weight). Additionally, each group was divided into two subgroups, with iron administered to piglets in subgroups IA and IIA on the first day of the experiment. In order to monitor the weight gains in pigs, they were weighed twice. To estimate the haematological status, blood samples were taken on the weaning day from selected piglets (10 in each subgroup). Haematological analyses were conducted using Hb, Ht, RBC, MCV, MCH, MCHC as early anaemia indicators. Additionally plasma iron (PI) and total iron-binding capacity (TIBC) were assessed as parameters of the actual and potential circulating extracellular iron. The aim of the study was to investigate the effect of additional postweaning Fe supplementation on production results. A lower concentration of PI was noted in weaker piglets (Group IA and IB). Throughout the experiment higher daily gains were noted in Group II; differences between Group IIA and IA as well as IB were statistically confirmed at p≤ 0,01. It might be expected that an additional Fe dose applied in weaning piglets can be used as a growth promoter. On the other hand, in case of cachectic animals toxicity of supplemental iron must be taken into consideration. Running title:

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Intramuscular versus Subcutaneous Administration of Iron Dextran in Suckling Piglets

Cited by 15 publications

References 9 publications

Iron Supplementation in Suckling Piglets: How to Correct Iron Deficiency Anemia without Affecting Plasma Hepcidin Levels

Iron Supplementation in Suckling Piglets: How to Correct Iron Deficiency Anemia without Affecting Plasma Hepcidin Levels

Parenteral iron administration in suckling piglets – a review

Can iron work for pigs as a booster?

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