2017
DOI: 10.1002/oby.21980
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Intramyocellular Lipid Droplet Size Rather Than Total Lipid Content is Related to Insulin Sensitivity After 8 Weeks of Overfeeding

Abstract: ObjectiveIntramyocellular lipid (IMCL) is inversely related to insulin sensitivity in sedentary populations, yet no prospective studies in humans have examined IMCL accumulation with overfeeding.MethodsTwenty-nine males were overfed a high-fat diet (140% caloric intake, 44% from fat) for 8-weeks. Measures of IMCL, whole body fat oxidation from a 24-hour metabolic chamber, muscle protein extracts, and muscle ceramide measures were obtained before and after the intervention.ResultsEight weeks of overfeeding did … Show more

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Cited by 28 publications
(34 citation statements)
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“…), diet‐induced metabolic dysfunction (Summers & Goodpaster, ; Covington et al . ) and severity of metabolic disease (Bosma et al . ; Summers & Goodpaster, ; Perreault et al .…”
Section: Discussionmentioning
confidence: 99%
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“…), diet‐induced metabolic dysfunction (Summers & Goodpaster, ; Covington et al . ) and severity of metabolic disease (Bosma et al . ; Summers & Goodpaster, ; Perreault et al .…”
Section: Discussionmentioning
confidence: 99%
“…These findings suggest that the accumulation of ceramides may not be a key factor in the development of insulin resistance with inactivity. Second, ceramides may be only linked to insulin resistance in cases of extreme of body mass (Skovbro et al 2008;Chee et al 2016), diet-induced metabolic dysfunction (Summers & Goodpaster, 2016;Covington et al 2017) and severity of metabolic disease (Bosma et al 2012;Summers & Goodpaster, 2016;Perreault et al 2018). Thus, the absence of body composition changes in the present study may indicate minimal involvement from ceramides during the initial stages of inactivity-induced insulin resistance.…”
Section: Figure 8 Associations Between Ceramide and Insulin Sensitivitymentioning
confidence: 99%
“…Indeed, electron microscopy studies have shown that the higher IMCL content in women is due to a greater number of IMCL, not a greater IMCL size (Devries et al 2007;Tarnopolsky et al 2007). As detailed above, greater IMCL size is related to IR (Chee et al 2016;Covington et al 2017), thus since IMCL size is not different between men and women, it is not surprising that women are not at a greater risk of developing T2D.…”
Section: R a F Tmentioning
confidence: 95%
“…ET reduces SS IMCL content (Nielsen et al 2010;Devries et al 2013;Samjoo et al 2013), redistributing it to the IMF and improves IS in T2D and obese men (Nielsen et al 2010;Samjoo et al 2013), but not obese women (Devries et al 2013). However, studies using fluorescence microscopy have shown that centrally located IMCL are inversely related to glucose disposal rate following a period of overfeeding (Covington et al 2017). These studies have also found that IMCL storage increases from the centre of the myofibril towards the sarcolemma and that elite athletes have a greater D r a f t amount of IMCL stored in the peripheral area of the myocyte as compared with sedentary or T2D individuals (van Loon 2004).…”
Section: Skeletal Muscle Lipid Storage Location Differs Based On Traimentioning
confidence: 99%
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