Intranasal abuse potential of an abuse-deterrent oxycodone formulation compared to oxycodone immediate release and placebo in nondependent, recreational opioid users

Setnik, Beatrice; Schoedel, Kerri A.; Bartlett, Cindy; Dick, C.; Hakim, Nasrat; Geoffroy, Pierre A.

doi:10.5055/jom.2017.0421

Cited by 4 publications

(1 citation statement)

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“…The ODG presented higher Ramsay scores at T2 and T3 than did the OG, DG, and CG (p < 0.05). These results were consistent with those of other reports (Setnik et al 2017). Perhaps, the sedative effects exerted from the time of injection onward increased the Ramsay scores.…”

Section: Discussionsupporting

confidence: 93%

Effects of dexmedetomidine combined with oxycodone on sedation effect, perioperative inflammatory response and immunity

Wang¹,

Zhang²,

Wu³

et al. 2020

All Life

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Dexmedetomidine is a novel, highly selective α2 adrenoceptor agonist, whereas oxycodone serves as a μand k-amboceptor agonist. To analyze the effects of dexmedetomidine combined with oxycodone in locally anesthetized patients undergoing transforaminal endoscopic resection of nucleus pulposus. 112 patients were evenly randomized into oxycodone group (OG), dexmedetomidine group (DG), oxycodone-dexmedetomidine combination group (ODG), and control group (CG). No significant difference among the four groups in terms of baseline information, recovery time, or atropine was found (p > 0.05). The mean arterial pressures (MAPs) and heart rates (HRs) in ODG reduced from the injection point and were dramatically lower over those in CG, and visual analog scale (VAS) scores in ODG at 1, 2, and 6 h following surgery were lower over those in other groups (p < 0.05). The combination of dexmedetomidine with oxycodone in the local anesthesia during analgesia and sedation of patients undergoing transforaminal endoscopic resection of the nucleus pulposus manifested tangible effects. Specifically, such improved perioperative inflammatory responses and controlled cellular immunity without promoting the onset of adverse reactions.

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Section: Discussionsupporting

confidence: 93%