Intranasal administration of white tea alleviates the olfactory function deficit induced by chronic unpredictable mild stress

Hu, Wenhao; Xie, Guixiang; Zhou, Tian; Tu, Jialu; Zhang, Jiayi; Lin, Zejie; Zhang, Haiyang; Gao, Liangcai

doi:10.1080/13880209.2020.1855213

Cited by 8 publications

(6 citation statements)

References 40 publications

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“…However, EM significantly suppressed the protein expression of inflammation in the olfactory bulb ( Figure 9 ). The administration of white tea, a kind of green tea product, improved the olfactory function of mice in the olfactory disorder model caused by chronic unpredictable mild stress of morphological and molecular levels by protecting against mitochondrial structural damage, such as cristae fracture and vacuolar degeneration [ 63 ]. In addition, the administration of chlorogenic acid and gallic acid in green tea improved the behavior dysfunction of rats subjected to bilateral olfactory bulbectomy [ 64 ].…”

Section: Discussionmentioning

confidence: 99%

Powdered Green Tea (Matcha) Attenuates the Cognitive Dysfunction via the Regulation of Systemic Inflammation in Chronic PM2.5-Exposed BALB/c Mice

et al. 2021

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This study was conducted to evaluate the anti-amnesic effect of the aqueous extract of powdered green tea (matcha) (EM) in particulate matter (PM)2.5-induced systemic inflammation in BALB/c mice. EM ameliorated spatial learning and memory function, short-term memory function, and long-term learning and memory function in PM2.5-induced mice. EM protected against antioxidant deficit in pulmonary, dermal, and cerebral tissues. In addition, EM improved the cholinergic system through the regulation of acetylcholine (ACh) levels and acetylcholinesterase (AChE) activity in brain tissue, and it protected mitochondrial dysfunction by regulating the production of reactive oxygen species (ROS), mitochondrial membrane potential (MMP) and ATP contents in brain tissue. EM attenuated systemic inflammation and apoptotic signaling in pulmonary, dermal, olfactory bulb, and hippocampal tissues. Moreover, EM suppressed neuronal cytotoxicity and cholinergic dysfunction in hippocampal tissue. This study suggests that EM might be a potential substance to improve PM2.5-induced cognitive dysfunction via the regulation of systemic inflammation.

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Section: Discussionmentioning

confidence: 99%

Powdered Green Tea (Matcha) Attenuates the Cognitive Dysfunction via the Regulation of Systemic Inflammation in Chronic PM2.5-Exposed BALB/c Mice

et al. 2021

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“…Sustained and unpredictable stress applied in the UCMS model may recapitulate the varied stressful life events that significantly elevate risk for disorder and depressive-like behavior in humans. In this model, a decrease in the number of olfactory receptors has been observed ( Li et al 2015 ) as well as reduced neurogenesis in the OB ( Yang et al 2011 ), and impaired olfactory discrimination ( Hu et al 2020 ). However, we are not aware of any studies assessing other aspects of olfactory behavioral performance following UCMS.…”

Section: Rodent Models Of Depressionmentioning

confidence: 99%

Relationship between depression and olfactory sensory function: a review

et al. 2021

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Links between olfactory sensory function and affect have been well established. A robust literature exists in both humans and animals showing that disrupting olfaction sensory function can elicit disordered mood state, including serve as a model of depression. Despite this, considerably less is known regarding the directionality and neural basis of this relationship, e.g. whether disruptions in sensory function precede and contribute to altered mood or if altered mood state precipitates changes in olfactory perception. Further, the neural basis of altered olfactory function in depression remains unclear. In conjunction with clinical studies, animal models represent a valuable tool to understand the relationship between altered mood and olfactory sensory function. Here, we review the relevant literature assessing olfactory performance in depression in humans and in rodent models of depressive-like behavioral states. Rodents allow for detailed characterization of alterations in olfactory perception, manipulation of experiential events that elicit depressive-like phenotypes, and allow for interrogation of potential predictive markers of disease and the cellular basis of olfactory impairments associated with depressive-like phenotypes. We synthesize these findings to identify paths forward to investigate and understand the complex interplay between depression and olfactory sensory function.

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“…Olfactory avoidance tests and olfactory sensitivity tests showed their relief of olfactory dysfunction. Pharmacological studies found that white tea reduced mitochondrial and synaptic damage in the olfactory bulb and enhanced the content of BDNF ( Table 1 ) [ 197 ].…”

Section: Intranasal Administration Of Antidepressant Active Ingredientsmentioning

confidence: 99%

Application of Intranasal Administration in the Delivery of Antidepressant Active Ingredients

et al. 2022

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As a mental disease in modern society, depression shows an increasing occurrence, with low cure rate and high recurrence rate. It has become the most disabling disease in the world. At present, the treatment of depression is mainly based on drug therapy combined with psychological therapy, physical therapy, and other adjuvant therapy methods. Antidepressants are primarily administered peripherally (oral and intravenous) and have a slow onset of action. Antidepressant active ingredients, such as neuropeptides, natural active ingredients, and some chemical agents, are limited by factors such as the blood–brain barrier (BBB), first-pass metabolism, and extensive adverse effects caused by systemic administration. The potential anatomical link between the non-invasive nose–brain pathway and the lesion site of depression may provide a more attractive option for the delivery of antidepressant active ingredients. The purpose of this article is to describe the specific link between intranasal administration and depression, the challenges of intranasal administration, as well as studies of intranasal administration of antidepressant active ingredients.

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Intranasal administration of white tea alleviates the olfactory function deficit induced by chronic unpredictable mild stress

Cited by 8 publications

References 40 publications

Powdered Green Tea (Matcha) Attenuates the Cognitive Dysfunction via the Regulation of Systemic Inflammation in Chronic PM2.5-Exposed BALB/c Mice

Powdered Green Tea (Matcha) Attenuates the Cognitive Dysfunction via the Regulation of Systemic Inflammation in Chronic PM2.5-Exposed BALB/c Mice

Relationship between depression and olfactory sensory function: a review

Application of Intranasal Administration in the Delivery of Antidepressant Active Ingredients

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