Intranasal delivery of MSC-derived exosomes attenuates allergic asthma via expanding IL-10 producing lung interstitial macrophages in mice

Ren, Jun; Liu, Yongzhe; Yao, Ye; Feng, Lifeng; Zhao, Xiaotong; Li, Zongjin; Yang, Liang

doi:10.1016/j.intimp.2020.107288

Cited by 55 publications

(33 citation statements)

References 25 publications

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“…Exposure to bacterial CpG DNA leads to IntMϕ expansion and augmentation of IL-10 production 29 , suggesting these cells may be inherently anti-inflammatory. Indeed, Cx3cr1 -mediated deletion of Il10 leads to increases susceptibility to allergic asthma in mice 60 . Production of platelet-derived growth factor (PDGF) by IntMϕs suggests they may also support fibroblast and epithelial homeostasis 61 .…”

Section: Macrophage Function In Healthmentioning

confidence: 99%

The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity

2022

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The last decade has been somewhat of a renaissance period for the field of macrophage biology. This renewed interest, combined with the advent of new technologies and development of novel model systems to assess different facets of macrophage biology, has led to major advances in our understanding of the diverse roles macrophages play in health, inflammation, infection and repair, and the dominance of tissue environments in influencing all of these areas. Here, we discuss recent developments in our understanding of lung macrophage heterogeneity, ontogeny, metabolism and function in the context of health and disease, and highlight core conceptual advances and key unanswered questions that we believe should be focus of work in the coming years.

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Section: Macrophage Function In Healthmentioning

confidence: 99%

The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity

2022

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“…Intranasal administration of MSCs-Exo has been researched in various diseases, including complete spinal cord injury 41 , microglia-mediated neuroin ammation 42 , and autism spectrum disorders 43 . It is noteworthy that intranasal delivery of MSC-Exo could substantially expand pulmonary IL-10-producing interstitial macrophages to protect against allergic asthma in mice 44 . However, research on intranasal delivery of MSC-Exo in AR is still scarce.…”

Section: Discussionmentioning

confidence: 99%

Intranasal Delivery of Mesenchymal Stem Cell Exosomes Modulates the Immune Response of Allergic Rhinitis via the MAPK Pathway in a Mouse Model

Yu¹,

Chen²,

Xu³

et al. 2021

Preprint

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BackgroundAllergic rhinitis (AR) is a non-infectious chronic inflammatory disease of the nasal mucosa, which is mainly mediated by IgE after the body is exposed to allergens. It has been shown that transplantation of human mesenchymal stem cells (MSCs) into AR animal models can improve the AR behavioral phenotype. Furthermore, there are recent studies that states exosomes are the main mediators of MSC therapy. However, the effect of exosomes on AR has not been investigated.MethodsIn the established AR mouse model, different concentrations of MSC-derived exosomes (MSCs-Exo) were applied via intranasal delivery. The AR symptom scores, the eosinophils in the nasal mucosal section, the inflammation infiltration in the spleen section, and IgE, ovalbumin-specific IgE (OVA-sIgE), histamine, IgG1, IgG2a and other Th1/Th2 related inflammatory factors were evaluated by Hematoxylin–eosin staining, Elisa, real-time PCR.ResultsWe found that intranasal administration of MSCs-Exo could not only reduce the behavior of nasal scratching and sneezing in mice, but also cause a decline in related immune indicators via the MAPK pathway, including the spleen index, tissue staining, and the expression of inflammation-related cytokines. Moreover, we found that the optimal concentration of MSCs-Exo was 4×108/mL. ConclusionThe significant beneficial effects of exosomes may be exploited to develop a new, non-invasive treatment strategy for AR.

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“…These particles, including microvesicles and nanoscale exosomes, are capable of encapsulating the proteins, lipid mediators, and nucleic acids (including miRNA) that play key roles in the development of pathological processes such as allergic asthma [145,146]. Moreover, these vesicles can serve both as biomarkers to help distinguish different types of allergies in patients and as particles to deliver active molecules that suppress further asthmatic pathogenesis and exacerbations [147][148][149].…”

Section: Extracellular Vesiclesmentioning

confidence: 99%

Packaging and Delivery of Asthma Therapeutics

et al. 2021

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Asthma is a life-altering, chronic disease of heterogenous origin that features a complex interplay of immune and environmental signaling. Although very little progress has been made in prevention, diverse types of medications and delivery systems, including nanoscale systems, have been or are currently being developed to control airway inflammation and prevent exacerbations and fibrosis. These medications are delivered through mechanical methods, with various inhalers (with benefits and drawbacks) existing, and new types offering some variety in delivery. Of particular interest is the progress being made in nanosized materials for efficient penetration into the epithelial mucus layer and delivery into the deepest parts of the lungs. Liposomes, nanoparticles, and extracellular vesicles, both natural and synthetic, have been explored in animal models of asthma and have produced promising results. This review will summarize and synthesize the latest developments in both macro-(inhaler) and micro-sized delivery systems for the purpose of treating asthma patients.

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Intranasal delivery of MSC-derived exosomes attenuates allergic asthma via expanding IL-10 producing lung interstitial macrophages in mice

Cited by 55 publications

References 25 publications

The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity

The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity

Intranasal Delivery of Mesenchymal Stem Cell Exosomes Modulates the Immune Response of Allergic Rhinitis via the MAPK Pathway in a Mouse Model

Packaging and Delivery of Asthma Therapeutics

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