Intranasal fentanyl for the management of acute pain in children

Murphy, Adrian; O’Sullivan, Ronan; Wakai, Abel; Grant, Timothy; Barrett, Michael J.; Cronin, John J.; McCoy, S; Hom, Jeffrey

doi:10.1002/14651858.cd009942

Cited by 26 publications

(37 citation statements)

References 20 publications

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“…A potential for fentanyl using the nasal route has been recently highlighted in a Cochrane review [29]. Comparing the efficacy of other medications cannot be based on the current evidence; however, a measurable effect of analgesia has been consistently shown when analgesics were provided en route to the hospital (LOE-2 and LOE-4).…”

Section: Efficacymentioning

confidence: 99%

Prehospital pain management of injured children: a systematic review of current evidence

Samuel

Steiner

Shavit

2015

The American Journal of Emergency Medicine

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Section: Efficacymentioning

confidence: 99%

Prehospital pain management of injured children: a systematic review of current evidence

Samuel

Steiner

Shavit

2015

The American Journal of Emergency Medicine

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“…It can be administered via IV or IN route for acute treatment of pain. The IN (transmucosal) route via a mucosal atomiser device offers an option that is needle free and effective within 5–10 min of administration , . In a mixed ED, patients received IN fentanyl faster than IV morphine and required fewer IV cannulations .…”

Section: Pharmacological Sedationmentioning

confidence: 99%

Paediatric procedural sedation within the emergency department

Krieser

Kochar

2016

J Paediatrics Child Health

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Procedural sedation and analgesia in children requires the use of non-pharmacological and pharmacological approaches to facilitate the management of painful procedures. The development of skills in such techniques has mirrored the development of paediatric emergency medicine as a subspecialty. Governance, education and credentialing must facilitate safe sedation practice, using a structured approach, as sedating children in the busy environment of an emergency department is not without risk. Emergency clinicians, patients and caregivers all have a role to play in developing a safe, effective sedation plan.

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“…Analgesia: The analgesic activity of fentanyl depends on the blood plasma drug level. These are the indicates for the relief of mild to severe pain [45,46].…”

Section: Medicinal Usesmentioning

confidence: 99%

Fentanyl - A Potent Opioid Analgesic: A Review

Sharma¹,

Nareda²,

Aziz³

et al. 2016

J Dev Drugs

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We describe the computational design of proteins that bind the potent analgesic fentanyl. Our approach employs a fast docking algorithm to find shape complementary ligand placement in protein scaffolds, followed by design of the surrounding residues to optimize binding affinity. Co-crystal structures of the highest affinity binder reveal a highly preorganized binding site, and an overall architecture and ligand placement in close agreement with the design model. We use the designs to generate plant sensors for fentanyl by coupling ligand binding to design stability. The method should be generally useful for detecting toxic hydrophobic compounds in the environment.

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Intranasal fentanyl for the management of acute pain in children

Cited by 26 publications

References 20 publications

Prehospital pain management of injured children: a systematic review of current evidence

Prehospital pain management of injured children: a systematic review of current evidence

Paediatric procedural sedation within the emergency department

Fentanyl - A Potent Opioid Analgesic: A Review

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