Intranasally Administered Interferon as Prophylaxis Against Experimentally Induced Influenza A Virus Infection in Humans

Treanor, John J.; Betts, Robert F.; Erb, Shirley; Roth, Frieda K.; Dolin, Raphael

doi:10.1093/infdis/156.2.379

Cited by 31 publications

(17 citation statements)

References 14 publications

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“…Replication of human influenza A virus in monocytes promotes viral spreading through a host body. IFNs were used for prophylaxis against experimentally induced influenza A virus infection in humans and mice (30,31). It was our working hypothesis, based on recently published data (8), that application of PAR 2 agonist could also play a role in the suppression of influenza A virus replication.…”

Section: Discussionmentioning

confidence: 99%

Agonists of Proteinase-Activated Receptor-2 Enhance IFN-γ-Inducible Effects on Human Monocytes: Role in Influenza A Infection

Feld¹,

Shpacovitch²,

Ehrhardt³

et al. 2008

The Journal of Immunology

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Proteinase-activated receptor-2 (PAR2) is expressed by different types of human leukocytes and involved in the development of inflammatory and infectious diseases. However, its precise role in the regulation of human monocyte and macrophage function during viral infection remains unclear. Also, the ability of PAR2 agonists to enhance the effects induced by immune mediators during infection or inflammation is still poorly investigated. Therefore, we investigated the ability of a PAR2 agonist to enhance IFN-γ-induced suppression of influenza A virus replication in human monocytes. We found that this effect correlates with an increased abundance of IκBα after costimulation of cells with PAR2 agonist and IFN-γ. Remarkably, coapplication of PAR2 agonist and IFN-γ also enhances the effects of IFN-γ on IFN-γ-inducible protein 10 kDa release, and CD64 and αVβ3 surface expression by human monocytes. Together, these findings indicate a potentially protective role of PAR2 activation during the progression of influenza A virus infection. This effect could be associated with the ability of PAR2 agonists to enhance IFN-γ-induced protective effects on human monocytes.

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Section: Discussionmentioning

confidence: 99%

Agonists of Proteinase-Activated Receptor-2 Enhance IFN-γ-Inducible Effects on Human Monocytes: Role in Influenza A Infection

Feld¹,

Shpacovitch²,

Ehrhardt³

et al. 2008

The Journal of Immunology

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“…For the latter group, we obtained infectivity risk based on research data where viral shedding was measured in volunteers challenged with wild-type influenza viruses4142434445464748. We mapped the viral shedding to infectivity8 and rescaled the infectivity curve according to the length of infectivity period.…”

Section: Methodsmentioning

confidence: 99%

Multi-scale modeling for the transmission of influenza and the evaluation of interventions toward it

Guo

Peters

et al. 2015

Sci Rep

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Mathematical modeling of influenza epidemic is important for analyzing the main cause of the epidemic and finding effective interventions towards it. The epidemic is a dynamic process. In this process, daily infections are caused by people's contacts, and the frequency of contacts can be mainly influenced by their cognition to the disease. The cognition is in turn influenced by daily illness attack rate, climate, and other environment factors. Few existing methods considered the dynamic process in their models. Therefore, their prediction results can hardly be explained by the mechanisms of epidemic spreading. In this paper, we developed a heterogeneous graph modeling approach (HGM) to describe the dynamic process of influenza virus transmission by taking advantage of our unique clinical data. We built social network of studied region and embedded an Agent-Based Model (ABM) in the HGM to describe the dynamic change of an epidemic. Our simulations have a good agreement with clinical data. Parameter sensitivity analysis showed that temperature influences the dynamic of epidemic significantly and system behavior analysis showed social network degree is a critical factor determining the size of an epidemic. Finally, multiple scenarios for vaccination and school closure strategies were simulated and their performance was analyzed.

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“…Interestingly, other studies of higher doses of IFN (1000~10,000 times more per day) showed no efficacy against influenza viruses (Hayden et al, 1983; Merigan et al, 1973; Phillpotts et al, 1984; Saito et al, 1985; Treanor et al, 1987), suggesting that the dose of IFN is an important consideration in assessing antiviral effectiveness. In animals, recent studies showed that IFN orally or intranasally delivered to mice (Beilharz et al, 2007; Grimm et al, 2007; Tumpey et al, 2007), guinea pig (Van Hoeven et al, 2009) or ferrets (Kugel et al, 2009) reduced influenza virus replication.…”

Section: Discussionmentioning

confidence: 99%

Biodegradable nanogels for oral delivery of interferon for norovirus infection

et al. 2011

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Intranasally Administered Interferon as Prophylaxis Against Experimentally Induced Influenza A Virus Infection in Humans

Cited by 31 publications

References 14 publications

Agonists of Proteinase-Activated Receptor-2 Enhance IFN-γ-Inducible Effects on Human Monocytes: Role in Influenza A Infection

Agonists of Proteinase-Activated Receptor-2 Enhance IFN-γ-Inducible Effects on Human Monocytes: Role in Influenza A Infection

Multi-scale modeling for the transmission of influenza and the evaluation of interventions toward it

Biodegradable nanogels for oral delivery of interferon for norovirus infection

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