Intraneural epithelial islands associated with a periapical cyst

George, Donald I.; Gould, Alan R.; Behr, Max M.

doi:10.1016/0030-4220(84)90261-5

Cited by 13 publications

(3 citation statements)

References 19 publications

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“…Its anterior extent is the point where the parotid duct pierces buccinator, and in the present case the cell cluster was located more anteriorly than this. Two previous odontogenic cysts have been reported with which the JOC was apparently associated; one was a radicular cyst, in the other the features of the cyst are not described, but in neither was the JOC proposed as the source of the cyst. The stimulus for cystic change and increased proliferative activity was not evident, but it has been suggested that chronic mild inflammation may be a contributing factor for epithelial proliferation in benign conditions.…”

Section: Discussionmentioning

confidence: 99%

Soft tissue keratocyst of the cheek mucosa associated with a cluster of epithelial nests: a case report

et al. 2017

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The vast majority of odontogenic keratocysts (keratocystic odontogenic tumour) (OKC) are intra-osseous, but a rare variant has been documented in the mucosa of the cheek. Despite its extra-osseous location, the source of this variant is assumed to be remnants of the dental lamina. We describe a keratocyst which was situated in the buccal space of a 76 year-old man. Microscopically, a cluster of epithelial nests was present in the cyst wall. Basal palisading and reversed nuclear polarity were features of both the nests and the cyst lining. Some nests had lumina. The epithelial cluster was adjacent to small nerves. The nests and the cyst lining were strongly positive for cytokeratin (CK) 5 and p63, and negative for CK18 and 20. CK7positive cells were present in the centre of the nests, but the cyst lining was entirely negative. CK8 and CK19 were strongly expressed by the epithelial nests, but only focally by the cyst lining. Whereas the nests were negative for Ki67, the cyst lining showed the pattern of basal and parabasal positive nuclei seen in OKC. The origin of these nests is uncertain; the most likely candidates are ectopic remnants of dental lamina, salivary glands, isthmus of the cutaneous hair follicle and the juxta-oral organ of Chievitz. On the basis of immunophenotype, we were unable to determine whether their presence was coincidental, or whether the epithelial nests were the source of the cyst. The cyst has not recurred in 34 years.Oral Surgery 10 (2017) e1--e6.

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Section: Discussionmentioning

confidence: 99%

Soft tissue keratocyst of the cheek mucosa associated with a cluster of epithelial nests: a case report

et al. 2017

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“…12,19 Although this behaviour has been compared with that of the cutaneous microcystic adnexal carcinoma, 3 there are also examples of benign jaw tumours that show neural infiltration, such as ameloblastoma, 27 as well as of normal structures that imitate neural infiltration. The latter include the juxtaoral organ of Chievitz 28 and neuroepithelial structure found in the lingual and buccal mandibular gingiva 29,30 ; normal jawbones 31,32 ; cysts, including a primordial cyst and an odontogenic keratocyst of the mandible, 33 a periapical cyst of the maxilla, 34 and a median nasopalatine duct cyst 35 ; and a buccal maxillary exostosis. 35 In neuroepithelial structures, the epithelium is mostly located beneath the perineurium, but perineural localization is not uncommon, 29,33,35,36 whilst intraneural localization was seen in some cases of SOC, 7,12,14 and the present one.…”

Section: Discussionmentioning

confidence: 99%

A central maxillary tumor with bland cytology, partly sclerotic stroma, and neural involvement. Sclerosing odontogenic carcinoma or epithelial neurotropism in an odontogenic fibroma?

et al. 2022

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Aim To present a maxillary tumour showing features of sclerosing odontogenic carcinoma (SOC), i.e. bland cytology, partly sclerotic stroma and neural involvement, and contemplate whether its diagnostic feature, neural involvement, could represent epithelial neurotropism in a central odontogenic fibroma (COdF). Materials and methods A 58‐year‐old male presented with a depression on the palatal side of the alveolar ridge, extending from the right canine to the right first molar tooth. A CBCT of the maxilla revealed a multilocular radiolucency, with ill‐defined borders, causing destruction of the buccal and palatal cortical bone. Results Complete removal of the tumour was performed under general anaesthesia. Healing was uneventful and there was no evidence of recurrence in the 36 months clinical and radiographical follow up. The final diagnosis was an odontogenic tumour with bland cytology, sclerosis and neural involvement, consistent with SOC. Conclusions The tumour presented herein showed clinical, radiographical and microscopical features consistent with SOC and COdF, with neural involvement favouring a diagnosis of SOC. Epithelial neurotropism in a COdF could account for the similarities between those lesions and the rather quiescent, for an infiltrative intraosseous carcinoma, clinical behaviour of SOC.

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“…The epithelium may be derived from the surface epithelium or from the epithelium of adjacent glands or hair follicles [ 11 ]. Intraneural epithelial islands have been reported in association with a radicular cyst in the mandible and maxilla [ 12 ]. In the reported case, we believe that the cystic epithelium either implanted below the periosteum during extraction of the offending tooth or fenestrated the bone.…”

Section: Discussionmentioning

confidence: 99%

Localization of a Peripheral Residual Cyst: Diagnostic Role of CT Scan

Jamdade

Nair

Kapoor

et al. 2012

Case Reports in Dentistry

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The termresidual cystis used most often for retained radicular cyst from teeth that has been removed. Residual cysts are among most common cysts of the jaws. The location of all odontogenic cysts is usually intraosseous. The peripheral (extraosseous) presentations are rare. The peripheral presentation of residual cyst has never been reported in the literature. In this article, the role of CT in diagnosing an unusual peripheral presentation of a residual cyst is discussed.

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Intraneural epithelial islands associated with a periapical cyst

Cited by 13 publications

References 19 publications

Soft tissue keratocyst of the cheek mucosa associated with a cluster of epithelial nests: a case report

Soft tissue keratocyst of the cheek mucosa associated with a cluster of epithelial nests: a case report

A central maxillary tumor with bland cytology, partly sclerotic stroma, and neural involvement. Sclerosing odontogenic carcinoma or epithelial neurotropism in an odontogenic fibroma?

Localization of a Peripheral Residual Cyst: Diagnostic Role of CT Scan

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