Intranodal Palisaded Myofibroblastoma: Report of Three New Cases

Rossi, Armando; Bulgarini, Antonella; Rondanelli, E; Incensati, Roberto

doi:10.1177/030089169508100618

Cited by 11 publications

(7 citation statements)

References 14 publications

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“…Similar to previous reported microscopic findings 1,4,5,7,8,10,16,24–27,32–34 , tumors in this study grew as small, well-circumscribed, often times pseudoencapsulated intraparenchymal nodules composed of benign-appearing spindled cells that frequently possess perinuclear vacuoles and exhibit nuclear palisading within tumor fascicles. One histological feature not previously documented is the focal presence of thin fascicles of rather evenly dispersed tumor cells within a collagenous stroma imparting a growth pattern vaguely reminiscent of desmoid-type fibromatosis.…”

Section: Discussionsupporting

confidence: 91%

“…IPM mostly affects adults, shows a male bias, and typically presents as a painless and less often tender, slow-growing inguinal mass 1,4,7,8,29 . The process is benign with no reported cases exhibiting destructive invasion or metastasis to date.…”

Section: Discussionmentioning

confidence: 99%

“…Studies report that trichrome histochemical staining 4,5,7,8,36 and anti-actin immunostaining 5,7,8,16,37 highlight the often times inconspicuous inclusion. Not restricted to IPM, the hyaline globule is a well-recognized hallmark of another myofibroblastic process, the infantile digital fibroma/fibromatosis 38 , and has also been described in a number of pathologically diverse myofibroblastic and smooth muscle proliferations 39 .…”

Section: Discussionmentioning

confidence: 99%

“…While many of the subsequent 39 studies of IPM in the English language literature [PUBMED] essentially reaffirmed these initial findings and the tumor’s predictably uneventful clinical course, others documented novel findings including occurrence of the lesion in lymph nodes outside the inguinal region 3,5–11 and in soft tissue 12 , ultrastructural evidence showing that the collagenous bodies are composed on type I collagen and not abnormally thickened amianthoid collagen fibers 13,14 , and the addition of cyclin D1 9,15–18 , D2–40 11 , and factor XIIIa 15 immunoexpression to the lesion’s established immunohistochemical profile of muscle specific actin, smooth muscle actin, muscle myosin, and vimentin positivity 1,4,7,8 .…”

Section: Introductionmentioning

confidence: 99%

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Intranodal Palisaded Myofibroblastoma

Laskin

Lasota

Fetsch³

et al. 2015

American Journal of Surgical Pathology

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Intranodal palisaded myofibroblastoma is a benign, lymph node-based myofibroblastic tumor of unknown pathogenesis. We report the clinicopathological, immunohistochemical, and genetic molecular features of this rare entity. The study cohort consisted of 14 males and 4 females ranging in age from 31 to 65 (mean, 47; median 49) years with tumors arising in inguinal lymph nodes (n=15), a neck lymph node (n=1), and undesignated lymph nodes (n=2). Most individuals presented with a painless mass or lump. Possible trauma/injury to the inguinal region was documented in four cases. Tumors ranged in size from 1.0 to 4.2 (mean, 3.1; median; 3.0) cm. Microscopically, the process presented as a well-circumscribed, often times pseudoencapsulated nodule (n=17) or nodules (n=1). Tumors consisted of a cellular proliferation of cytologically bland, spindled cells arranged in short fascicles and whorls within a finely collagenous(n=11) or myxocollagenous(n=7) matrix. In 12 tumors, scattered fibromatosis-like fascicles of spindled cells were noted. Histological features characteristic of the process included nuclear palisades (n=16 cases), collagenous bodies (n=15), and perinuclear intracytoplasmic hyaline globules (n=10). Mitotic activity ranged from 0 to 8 (mean,2; median, 1) mitotic figures/50 high-powered fields with no atypical division figures identified. Immunohistochemically, all tumors tested expressed (vimentin (n=3), smooth-muscle actin and/or muscle-specific actin (n=5, each), and nuclear beta-catenin and cyclin D1 (n=8, each). The latter two results prompted a screening for mutations in the beta-catenin gene glycogen synthase kinase-3 beta phosphorylation mutational “hotspot” region in exon 3 using PCR amplification and Sanger sequencing. Single nucleotide substitutions leading to missense mutations at the protein level were identified in 7 of 8 (88%) analyzed tumors and are responsible for the abnormal expression of beta-catenin and cyclin D1. These results demonstrate that mutational activation of the beta-catenin gene is likely a pivotal event in the pathogenesis of intranodal palisaded myofibroblastoma.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Intranodal Palisaded Myofibroblastoma

Laskin

Lasota

Fetsch³

et al. 2015

American Journal of Surgical Pathology

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“…Submandibular and cervical lymph nodes were also reported as rare originating sites (4)(5)(6). To our knowledge, approximately 53 cases of IPM have been reported in the English-language literature (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). The ages of patients ranged from 19 years to 71 years.…”

Section: Introductionmentioning

confidence: 99%

Intranodal Palisaded Myofibroblastoma; a Case Report and Review of the Literature

Köseoğlu

Özkan

Filiz

et al. 2008

Pathol. Oncol. Res.

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Intranodal palisaded myofibroblastoma (IPM) also called as intranodal hemorrhagic spindle cell tumor with amianthoid fibers is a distinctive and rare mesenchymal neoplasm of lymph nodes. This entity generally misdiagnosed as intranodal Kaposi's sarcoma or schwannoma in past. In contrast to Kaposi's sarcoma, it behaves in a benign fashion and does not need any further therapy except total surgical resection of the mass. This neoplasm has a great predilection for the inguinal region. The lesion presents typically as a unilateral, painless, solitary mass. To our knowledge, approximately 53 cases of IPM have been reported in the English-language literature. We present a 43-year-old-male patient with IPM and discuss histological, immunohistochemical features and pathogenesis of this rare benign neoplasm.

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Hepatobiliary Castleman Disease

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Intranodal Palisaded Myofibroblastoma: Report of Three New Cases

Abstract: Intranodal palisaded myofibroblastoma is a well-defined entity in the group of spindle-cell neoplasms of lymph nodes. The authors report 3 new cases of this unusual tumor. The nature of the proliferating cells is discussed.

Cited by 11 publications

References 14 publications

Intranodal Palisaded Myofibroblastoma

Intranodal Palisaded Myofibroblastoma

Intranodal Palisaded Myofibroblastoma; a Case Report and Review of the Literature

Hepatobiliary Castleman Disease

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