Intranuclear inclusions containing melanosomes observed after PUVA therapy: A study of five psoriatic patients

Distinctive eosinophilic cytoplasmic inclusion bodies in melanocytic nevi: an immunohistochemical and ultrastructural study

“…In the skin, intranuclear pseudoinclusions, also termed ‘cytoplasmic invaginations', are common to both melanocytic nevi and melanomas. It is well known that pseudoinclusions can be induced in melanocytes by exposure to various viruses and therapies 1,2 …”

True intranuclear inclusions in a melanocytic nevus: report of a case and review of the literature

“…In contrast, true intranuclear inclusions/bodies have been rarely reported in melanocytes of normal skin, 2 in epidermal melanocytes following psoralen‐ultraviolet A (PUVA) therapy 16 and in melanocytic tumors 15,17–23 . These true nuclear inclusions are present within the nuclear matrix and lack a border membrane 2,15–23 . Hentzer and Kobayasi 2 identified nuclear bodies (0.3–0.6 μm in average diameter) with sparse (type I) and concentrically arranged (type II) fibrils, without granules, and surrounded by a lucent halo in 2 of 16 melanocyte nuclei in normal adult human skin.…”

“…Hentzer and Kobayasi 2 identified nuclear bodies (0.3–0.6 μm in average diameter) with sparse (type I) and concentrically arranged (type II) fibrils, without granules, and surrounded by a lucent halo in 2 of 16 melanocyte nuclei in normal adult human skin. Ree 16 found that epidermal melanocytes showed intranuclear melanosome‐like bodies and nuclear bodies after PUVA therapy. Bhawan and Silva 22 described small, well‐circumscribed intranuclear virus‐like inclusions (0.6–1.0 μm in diameter) composed of electron‐dense tubular structures on electron microscopy in an amelanotic melanoma metastatic to the jejunum in a 35‐year‐old man.…”