1994
DOI: 10.1089/jop.1994.10.677
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Intraocular Diclofenac and Flurbiprofen Concentrations in Human Aqueous Humor Following Topical Application

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Cited by 38 publications
(25 citation statements)
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“…19 Though C max (78.7 Ϯ 68.1 ng/mL) in humans is lower than 86.5 ng/mL in rabbits, 19 this may simply be the result of species differences whose blink rate is greater in humans, and corneal and conjunctival surface area in rabbits are about twice the area as humans. 42,43 Most recently, McNamara and colleagues replicated our study in albino rabbits. 10 They confirmed that a single drop of radiolabeled bromfenac ophthalmic solution 0.09% (commercially available concentration), produced peak tissue concentrations within 2 h and that drug was measurable in all ocular tissues, including the cornea and aqueous humor, the iris-ciliary body, choroid, and the retina, for at least 24 h (Fig.…”
Section: Discussionmentioning
confidence: 66%
“…19 Though C max (78.7 Ϯ 68.1 ng/mL) in humans is lower than 86.5 ng/mL in rabbits, 19 this may simply be the result of species differences whose blink rate is greater in humans, and corneal and conjunctival surface area in rabbits are about twice the area as humans. 42,43 Most recently, McNamara and colleagues replicated our study in albino rabbits. 10 They confirmed that a single drop of radiolabeled bromfenac ophthalmic solution 0.09% (commercially available concentration), produced peak tissue concentrations within 2 h and that drug was measurable in all ocular tissues, including the cornea and aqueous humor, the iris-ciliary body, choroid, and the retina, for at least 24 h (Fig.…”
Section: Discussionmentioning
confidence: 66%
“…The disclosed concentration of benzalkonium chloride is 0.002% to 0.01%, that of benzoate is 0.02% to 0.04%, and that of chlorobutanol is 0.25% to 0.5%. Dilutions in aqueous humor after instillation are known in Diclod (1:100,000) 13 and Bronuck (1:10,000). 14 Bronuck generates a smaller contact angle and higher intraocular concentrations than Diclod.…”
Section: Discussionmentioning
confidence: 99%
“…Although previous reports have studied the ocular pharmacokinetics of diclofenac after topical application in physiological conditions [8,9], there are no studies regarding the ocular penetration and pharmacokinetics of diclofenac in inflamed eyes. Hence, it is not known whether an inflammatory condition in the eye can modify the pharmacokinetics of diclofenac, which is important for establishing an optimal schedule of topical treatment depending on the target tissue of the inflammatory process.…”
Section: Discussionmentioning
confidence: 99%
“…In this respect, and due to the lack of similar studies in humans, it is not possible to compare our results with other reports. During cataract surgery, in which an inflammtory process is also induced, Ellis et al [14] reported that diclofenac reached a high level in aqueous humor of 82 ng/ml at 2.4 h after instillation. This level is lower than those found in the present study in the aqueous humor from either keratitic or uveitic rabbit eyes, but this discrepancy could be attributed to the differences in the inflammatory response here studied.…”
Section: Discussionmentioning
confidence: 99%
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