Intraocular inflammatory mass associated with lens-induced uveitis

Johnson, Jean Guffey; Margo, Curtis E.

doi:10.1016/j.survophthal.2016.12.013

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…Some aspects of the ALK activation mechanism in IMT are also seen in some anaplastic large cell lymphomas(ALCLs) [1]. Light microscopically, the ALCLs are typically composed of interwoven fascicles of histiocytes and myo broblasts mixed with chronic in ammatory cells, mostly T lymphocytes [17]. The tumor in our patient does not conform to ALCL because of the large proportion of collagenized brous tissue, and smooth muscle-like cells.…”

Section: Discussionmentioning

confidence: 87%

Inflammatory Myofibroblastoma Tumor of Intraocular Ciliary Body: A Case Report and Literature Review

Yu¹,

Tong²,

Weiqing³

et al. 2020

Preprint

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Background: IMTs are extremely rare in eyes. This is the first report of a IMT of the ciliary body.Case presentation: A ciliary body tumor was found under slit lamp biomicroscopy in a 55-year-old male first diagnosed with cataract. Then this patient underwent trans-sclera resection via partial lamellar sclerouvectomy and par plans vitrectomy to remove the mass. Hematoxylin and eosin (HE) staining and immunohistochemistry findings showed that the characteristics of the tumor were consistent with inflammatory myofibroblastoma tumor (IMT).Conclusions: we reported a rare case of intraocular IMT, which is confirmed by H&E staining, and IHC positive staining for Vimentin, Desmin and ALK, while negative staining for SMA, S-100, ki-67, CK, CD68, and calponin.

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Section: Discussionmentioning

confidence: 87%

Inflammatory Myofibroblastoma Tumor of Intraocular Ciliary Body: A Case Report and Literature Review

Yu¹,

Tong²,

Weiqing³

et al. 2020

Preprint

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“…On light microscopy analysis, ALCLs are typically composed of interwoven fascicles of histiocytes and myofibroblasts combined with chronic inflammatory cells (e.g. T lymphocytes) [ 19 ]. The tumour in our patient was not regarded as ALCL, because of the large proportions of collagenised fibrous tissue and smooth muscle-like cells.…”

Section: Discussionmentioning

confidence: 99%

Intraocular myofibroblastoma tumour of the ciliary body: a case report and literature review

Zhang

Tong

et al. 2022

BMC Ophthalmol

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Background Inflammatory Myofibroblastoma Tumors (IMTs) are extremely tumour rare in the intraocular. Case presentation A ciliary body tumor was found under slit lamp biomicroscopy in a 55-year-old male first diagnosed with cataract. Then this patient underwent trans-sclera resection via partial lamellar sclerouvectomy and par plans vitrectomy to remove the mass. Hematoxylin and eosin (HE) staining and immunohistochemistry findings showed that the characteristics of the tumor were consistent with IMT. Conclusions We reported a rare case of intraocular IMT, which is confirmed by H&E staining, and IHC positive staining for Vimentin, Desmin and ALK, while negative staining for SMA, S-100, ki-67, CK, CD68, and calponin.

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“…Veromman [3] concluded that although no evidence of malignant tumoral growth was found in human crystalline cells, abnormal and benign growths of lens cells can present with cell atypia [3] and associate with cataract formation. While seemingly paradoxically alike with Schrodinger's cat [4], inflammatory mases related to previous episodes of uveitis [5] or melanoma metastases [6] were documented to disguise as lens masses under the term "Masquerade tumors".…”

Section: Introductionmentioning

confidence: 99%

Traumatic Intralenticular Neovascularization in a HLA B27+ Pediatric Patient

et al. 2021

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(1) Background: Intralenticular tumors are an entity akin to Schrodinger’s cat since, although the human crystalline cells themselves are not known to malignly proliferate, various entities can take the appearance and clinical presentation of a tumor originating in the lens. We present the peculiar case of an 11-year-old male patient of African descent, HLA B27+, with a previous history of minor ocular trauma and unilateral anterior uveitis a year before which was admitted to our department with total opacification of the crystalline lens in the right eye and lens neovascularization. During surgery, a vascular, white fibrotic mass measuring 0.1–0.2 cm was discovered inside the lens bag and was excised. (2) Methods: Retrospective case review. (3) Results: The histopathological exam of the excised mass revealed an abundant infiltrate consisting of CD68+ foamy macrophages and lymphoplasmacytic elements. CD68 is a pan-macrophage marker associated with an active inflammatory mechanism soliciting macrophages, and tissue activated macrophages are correlated to increased stromal and serum levels of vascular endothelial growth factor, providing an explanation for lens angiogenesis. (4) Conclusions: The diagnosis is of a “masquerade tumor” resulted from an abnormal inflammatory process in connection with previous ocular trauma and possibly the patient’s HLA B27+ status.

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Intraocular inflammatory mass associated with lens-induced uveitis

Cited by 5 publications

References 27 publications

Inflammatory Myofibroblastoma Tumor of Intraocular Ciliary Body: A Case Report and Literature Review

Inflammatory Myofibroblastoma Tumor of Intraocular Ciliary Body: A Case Report and Literature Review

Intraocular myofibroblastoma tumour of the ciliary body: a case report and literature review

Traumatic Intralenticular Neovascularization in a HLA B27+ Pediatric Patient

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