Blue-light filtering intraocular lenses are purported to reduce the incidence of potentially damaging UV and blue light on the retina. This article reviews their background, the proposed benefits on long-term eye health and the possible disadvantages on circadian rhythm, scotopic vision and colour vision.
KeywordsAge-related macular degeneration, blue-light filtering, circadian rhythm, intraocular lenses, light hazard, retina, ultraviolet The manufacturers of IOLs have now extended the concept of filtering radiation to include short-wavelength blue light (400-500 nm) from the visible spectrum. Blue-light filtering IOLs attenuate wavelengths up to 500 nm. They are readily available to surgeons but at a higher cost compared to standard UV-only blocking lenses. However, there has been controversy as to the extent of any benefit these IOLs provide and there are suggestions that they may have a detrimental effect on vision and the circadian rhythm.
Light HazardWith high oxygen levels and constant absorption of radiation in the form of light during waking hours, photo-oxidative reactions occur within the retina and choroid. UV and visible wavelengths up to 600 nm are capable of photochemically damaging the retina, with short-wavelength radiation being more damaging than long-wavelengths. and other posterior pole pathologies.The eye attempts to limit the effects of phototoxicity by shedding photoreceptor outer segments, synthesising antioxidants such as lutein and zeaxanthin within the retina and producing light absorbing pigments such as melanin within the retinal pigment epithelium (RPE) and choroid. 12 The ageing eye is less likely to be able to sustain these protective mechanisms leaving the eye prone to phototoxic damage.
2Lipofuscin is a phototoxic pigment, which naturally accumulates within the retina as the eye ages. It has a peak absorption at 430 nm. 13 Photons absorbed by lipofuscin molecules are raised to an excited state and this results in the production of reactive oxygen species such as singlet oxygen and superoxides as well as free-radicals. Reactive species damage ocular tissue at a cellular level and this reduces the ability of the RPE cells to regulate photoreceptor cell turnover. Eventually the photoreceptors undergo permanent and atrophic damage.
2,7The crystalline lens provides some protection against phototoxicity.In the first three years of life the lens is clear, gradually becoming yellow over time. Pigments comprised of 3-hydroxyl kynurnine are deposited in the lens, particularly in the lens nucleus where UVA (315-400 nm) and UVB (280-315 nm) are absorbed. 2 These pigments, often referred to as chromophores, absorb light wavelengths between 300 and 400 nm preventing UVA, most UVB and some blue-light from reaching the retina.A 53-year-old healthy crystalline lens will allow 75 % of 470 nm blue light to be transmitted, whilst a 70 year old allows only 25 %. 14 Studies haveshown that transmission of blue light through the crystalline lens decreases by 0.7-0.8 % per year because of chromo...