Intraocular metastasis from primary cervical cancer: A case report and review of the literature

Uhrinak, Abby; Tierney, Katherine E.; Duncun, Kara L.; Matsuo, Koji

doi:10.1016/j.gore.2015.03.003

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…However, the orbital mass nearly doubled in size over the following month [ 15 ]. In contrast, 3 patients received RT to the orbit, and improved their ocular symptoms [ 19 , 21 , 24 ]. Our case and other reports suggest that local orbital radiotherapy may result in a partial or complete response in over half of the patients.…”

Section: Discussionmentioning

confidence: 99%

Uncommon Hematogenous Metastasis: Orbital Involvement in Uterine Cervical Cancer

Yamaguchi,

Koizumi,

Kakuda

et al. 2023

Am J Case Rep

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Patient: Female, 70-year-old Final Diagnosis: Uterine cervical cancer Symptoms: Sight loss and exophthalmos Clinical Procedure: — Specialty: Obstetrics and Gynecology Objective: Rare disease Background: Although screening for uterine cervical cancer (UCC) and vaccination programs for human papilloma virus (HPV) have been implemented in many countries, women >65 years may not have access to or comply with cervical cancer screening. Women >65 years may present with advanced-stage cervical carcinoma with a poor outcome. Metastatic UCC is often diagnosed, and there are 2 types of metastases related to different treatments and survival rate: hematogenous metastasis and lymphatic metastasis. Hematogenous metastasis is relatively unusual, and it most commonly involves lung and bone locations. Orbital metastasis is an extremely rare hematogenous metastasis in patients with UCC. Case Report: A 70-year-old woman receiving dialysis presented to a local hospital due to general fatigue for 5 months. She was diagnosed with locally advanced UCC and underwent radiation therapy (RT). Twenty days after RT, skin masses appeared, and 34 days after RT, right exophthalmos induced by an orbital mass appeared. We diagnosed skin and orbital masses as metastases from UCC, and performed RT to the orbital tumor. The tumor shrank and the visual symptoms disappeared. Regrettably, the patient died of cancer 7 months after the orbital RT; however, no eye symptoms recurred until her death. Conclusions: This report describes a rare presentation of UCC with metastasis to the orbit, and highlights that cervical cancer may still present at an advanced stage, particularly in older women. In this case, RT to the orbital metastasis from UCC was effective and contributed to the patient’s quality of life.

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Section: Discussionmentioning

confidence: 99%

Uncommon Hematogenous Metastasis: Orbital Involvement in Uterine Cervical Cancer

Yamaguchi,

Koizumi,

Kakuda

et al. 2023

Am J Case Rep

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“…Among the primary cancers with intraocular metastasis, breast and lung comprise for two thirds of cases. Among the other sites for primary, carcinoma of cervix has also been documented which also happens to be the most common gynecologic malignancy and also the fourth most common type of cancer in women [21]. In literature 13 cases of documented cervical carcinoma metastasizing to the eye have been reported, spreading via local extension, lymphatics and haematogenous route [22].…”

Section: Discussionmentioning

confidence: 99%

Vogt-Koyanagi-Harada Disease and Vogt-Koyanagi-Harada Resembling Syndrome

Arora¹,

Gupta²,

Parasher³

et al. 2021

IJOVS

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Background: To present myriad and unique presentation of Vogt-Kayanagi-Harada Disease (VKHD) and Vogt-Koyanagi-Harada (VKH) resembling syndrome. Methods: This is observational series of four cases of VKH disease with variable unique visual presentation which ranged from blurring of vision, tinnitus, hot flushes on face and abdomen, presence of floaters with hedache, breathlessness and history of weight loss. The patient age ranged from 14-56 years. Symptoms developed acutely ranging from 4-12 weeks. Visual acuity varied from 1/60 to 6/6 on Snellen chart. A detailed ophthalmic evaluation, radio imaging and neuroimaging were done as needed on patients. FFA confirmed disc leakage, subretinal pooling of dye in posterior pole and pin point leaks in three cases. The fourth case revealed dilated capillaries, pin point leaks outside zone of hyperflourescence and presence of leopard spots.USG B-scan in same case showed choroidal thickening and an oval hypointense juxtapappilary lesion. OCT-macula revealed a convex retinal profile, thickening of retinal pigment epithelium choriocapillaries complex, multiple subretinal low reflective areas consisting with serous neurosensory detachment and hyper reflective spots in inner retinal areas consistent with findings suggestive of metastasis. All four patients presented in acute uveitic stage. Barring one patient, three patients had bilateral disease. Incomplete VKH disease was diagnosed in three cases. Metastatic intraocular carcinoma with multiorgan involvement with primary in cervix was diagnosed in one case. Two cases of VKH disease were in remission having responded well to oral steroids and immunesuppresive therapy. One case passed to chronic stage with visual deterioration. One case with multi-organ metastasis went on to receive chemotherapy, brachytherapy, whole body and pelvic radiation. Conclusions: VKH disease has variable presentation and a high degree of suspicion is needed to differentiate it from similar occurring malignant and non-malignant intraocular inflammation. Early staging of VKH disease helps in planning adequate treatment leading to greater improvement in disease outcome and simultaneously preventing progression to chronic stage.

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“…The reason for diminution of vision in these cases is due to the involvement of cilioretinal artery and optic neuropathy secondary to the mass effect of the lesion. There are very few treatment options available as the tumour lies posteriorly at orbit so surgical approach is avoided, hence supportive chemotherapy or palliative radiotherapy is the only treatment available 7–10…”

Section: Discussionmentioning

confidence: 99%

Cervical carcinoma leading to orbital apex syndrome and blindness

Wadhwani

Phuljhele²,

Kumar

et al. 2019

BMJ Case Rep

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Orbit is an unusual and rare site for metastases from cancer. The most frequent site of a primary malignancy to metastasise to the orbit is the breast, followed by the lung. The malignant mixed mullerian tumour is a rare uterine and cervical carcinoma and accounts for <5% of uterine cancers. It is the primary tumour of the uterus, and de novo involvement of the cervix itself is extremely rare. We report the first case of cervical carcinoma with mixed mullerian aetiology to be associated with orbital metastasis and eventually leading to blindness and death

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Intraocular metastasis from primary cervical cancer: A case report and review of the literature

Cited by 5 publications

References 8 publications

Uncommon Hematogenous Metastasis: Orbital Involvement in Uterine Cervical Cancer

Uncommon Hematogenous Metastasis: Orbital Involvement in Uterine Cervical Cancer

Vogt-Koyanagi-Harada Disease and Vogt-Koyanagi-Harada Resembling Syndrome

Cervical carcinoma leading to orbital apex syndrome and blindness

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