Intraocular Ossification and Hematopoiesis

Finkelstein, Elliot; Boniuk, Milton

doi:10.1016/0002-9394(69)91253-7

Cited by 41 publications

(32 citation statements)

References 4 publications

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“…The inflammation and anatomical disruption associated with these settings appear to cause the RPE to fibrose and rarely become bone. Boniuk et al found in their series that most ocular bone formation takes 10 -12 years following insult [2]. This corresponds to our patient, whose insult occurred during infancy followed by the development of bone ten years later.…”

Section: Discussionsupporting

confidence: 89%

“…While calcification can be seen in degenerating tissues, [1] ossification generally requires abundant blood supply [1] and a fibroblastic response [2]. The anatomy of the posterior segment including the RPE and choroid provided such a blood supply [5], while scarring and inflammation from the patient's previous CMV chorioretinitis provided the fibrovascular response needed.…”

Section: Discussionmentioning

confidence: 99%

“…The inflammation and anatomical disruption associated with these settings appear to cause the RPE to fibrose and rarely become bone. Because it is uncommon for children to suffer these ocular changes, most cases of subretinal bone formation occur in adults, but the age of presentation can be varied [1,2]. In addition, our case is unusual given the age of the patient, the relative sparing of vision until late in the disease process, as well as the inciting factor of cytomegalovirus (CMV) retinitis for the formation of bone and subsequent tractional retinal detachment.…”

Section: Introductionmentioning

confidence: 90%

“…It often occurs in eyes with multiple ocular surgeries, inflammation, severe trauma, long standing retinal detachment, or phthisis bulbi which have a poor visual prognosis [1][2][3][4]. The inflammation and anatomical disruption associated with these settings appear to cause the RPE to fibrose and rarely become bone.…”

Section: Introductionmentioning

confidence: 99%

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Osseous Metaplasia Leading to Traction Retinal Detachment in the Nonphthisical Eye of Young Boy with Cytomegalovirus Retinitis

Vemulakonda¹,

Sonnen²

2013

AID

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Title: Osseous Metaplasia Leading to Traction Retinal Detachment in the nonphthisical eye of Young Boy with Cytomegalovirus Retinitis. Purpose: To report a case of intraocular bone formation in an 11-year-old boy with a history cytomegalovirus (CMV) retinitis secondary to immunosuppression following Bone Marrow Transplantation due to hyper Immunoglobulin G (IgG) syndrome. Methods: An 11-year-old male presented with decreased vision in his better seeing eye. Clinical examination and Bscan ultrasound discovered a tractional retinal detachment with a large subretinal lesion. The patient was taken for surgical intervention. Results: The subretinal lesion was removed during surgery, and histopathologic evaluation revealed mature lamellar bone. Conclusion: This case shows that mature intraocular bone can be associated with tractional retinal detachment in a nonphthisical eye.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Osseous Metaplasia Leading to Traction Retinal Detachment in the Nonphthisical Eye of Young Boy with Cytomegalovirus Retinitis

Vemulakonda¹,

Sonnen²

2013

AID

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“…The occurrence of malignancy in an eye containing bone was discussed in the review of intraocular ossification in the human eye [9]. The authors observed a human eye with choroidal melanoma containing a plaque of bone and cite Reese's description of a malignant melanoma associated with intraocular ossification and longstanding retinal detachment.…”

Section: Discussionmentioning

confidence: 99%

Osteosarcoma in a Phthisical Feline Eye

et al. 1983

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Abstract. Eight years ago a cat sustained injury to the left globe and phthisis bulbi ensued. Two months prior to presentation, a firm intraorbital and periorbital mass developed and enucleation was done; histologic examination revealed osteogenic sarcoma. This is the first histologically documented report of osteosarcoma occurring in association with phthisis bulbi.Intraocular bone formation has been noted in a variety of conditions affecting eyes in man and animals [7,15]. Although intraocular ossification is a relatively frequent finding on examination of enucleated globes, we found only one report in the literature of osteogenic sarcoma occurring in a globe previously known to contain bone [8]. This paper describes a case of osteogenic sarcoma in a phthisical eye of a cat. Case HistoryA ten-year-old female, gray-white, domestic short-haired cat sustained an injury to the left globe eight years ago, with the subsequent development of phthisis bulbi. In late January 1980, a firm enlarging mass was described in the left orbit and was interpreted clinically to represent enlargement of the phthisical eye. A general physical examination revealed no swellings involving the long bones, ribs, or other skeletal structures. Topical therapy did not resolve the orbital mass. Mineralization of orbital and periorbital tissues was found in skull radiographs. No osteolysis or periosteal elevation involving the orbital rim or zygomatic arch was present. The cat was referred for surgery and enucleation was done.Following discharge, the cat became lethargic and anorectic, soon developed seizures, and subsequently became stuporous. The cat continued to deteriorate neurologically and was killed. Permission for necropsy was denied. ResultsOn gross examination the enucleation specimen consisted of two crescentic masses of tissue measuring 1.5 X 1.5 X 0.6 em. One crescentic mass was tan in color and lobulated on its margin. The boundaries of the globe were not well-defined grossly.Microscopic examination revealed a globe containing viable bone, necrotic bone, and a neoplastic growth. The only recognizable anterior segment structures were the 209

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Choroidal Hematopoiesis in an Adult

Bethel²,

Ks³

et al. 1996

Arch Ophthalmol

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Intraocular Ossification and Hematopoiesis

Cited by 41 publications

References 4 publications

Osseous Metaplasia Leading to Traction Retinal Detachment in the Nonphthisical Eye of Young Boy with Cytomegalovirus Retinitis

Osseous Metaplasia Leading to Traction Retinal Detachment in the Nonphthisical Eye of Young Boy with Cytomegalovirus Retinitis

Osteosarcoma in a Phthisical Feline Eye

Choroidal Hematopoiesis in an Adult

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