Intraocular pressure adjusted for central corneal thickness as a screening tool for open-angle glaucoma in an at-risk population

Sardos, Alexandre de Saint; Fansi, Alvine Kamdeu; Chagnon, Miguel; Harasymowycz, Paul

doi:10.3129/i09-129

Cited by 8 publications

(4 citation statements)

References 30 publications

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“…However, recent studies have found that adjusting for the impact of corneal thickness on intraocular pressure by correction algorithms is unlikely to improve tonometry as a screening tool for glaucoma. 27,28 The difference in prevalence of glaucoma in subjects with DE and subjects without DE was not significant after adjusting for age and sex, but when symptoms were excluded from the analysis, differences became significant for several DE tests. Nonpreserved antiglaucomatous medication, which was taken by 76.2% of glaucoma patients, but also pseudoexfoliation, could be among the main factors for the occurrence of signs of DE in this group of subjects.…”

Section: Discussionmentioning

confidence: 91%

The Association of Meibomian Gland Dysfunction and Other Common Ocular Diseases With Dry Eye: A Population-Based Study in Spain

Viso

Gudé

Rodríguez‐Ares

2011

Cornea

101

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Section: Discussionmentioning

confidence: 91%

The Association of Meibomian Gland Dysfunction and Other Common Ocular Diseases With Dry Eye: A Population-Based Study in Spain

Viso

Gudé

Rodríguez‐Ares

2011

Cornea

101

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“…Also, there could be other factors that may account for the differences in the Goldmann IOP and the PASCAL IOP, such as the age-related and physiological variation in the hydration of cornea, which cannot be measured in vivo at present time. Other studies that have examined the effect of CCT on Goldmann IOP have also discounted the benefit of using the correction algorithms that are solely based on corneal thickness because the error in tonometry due to corneal parameters is multidimensional, of which corneal thickness is a small part of the equation and may not aid in better clinical care or outcome 10,29,30…”

Section: Discussionmentioning

confidence: 99%

Measuring accurate IOPs: Does correction factor help or hurt?

Gunvant¹,

Newcomb²,

Kirstein³

et al. 2010

OPTH

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Purpose:To evaluate if using the Ehlers correction factor on the intraocular pressure (IOP) measured using the Goldmann applanation tonometer (GAT) improves its agreement with the PASCAL dynamic contour tonometer (DCT).Patients and methods:A total of 120 eyes of 120 individuals were examined. Participants underwent IOP measurement with both the DCT and the GAT and central corneal thickness measurement. The Ehlers correction factor was applied on the GAT IOP measurements to calculate Ehlers-corrected GAT IOP. The agreement between the DCT and GAT, and DCT and Ehlers-corrected GAT IOP was analyzed. The analyses were repeated by stratifying the data by race.Results:The mean IOP of the GAT, DCT, and the Ehlers-corrected GAT was 15.30, 16.78, and 14.68 mmHg, respectively. The agreement as assessed by Bland–Altman plot for the GAT with the DCT and DCT and Ehlers-corrected GAT IOP was +4.1 to −6.9 and +4.15 to −8.25 mmHg, respectively. The results were similar even when stratifying the data by race.Conclusion:Using Ehlers correction factor to account for the effect of corneal parameters on the IOP measured by the GAT worsens the agreement with the DCT. This effect remains even when stratifying the data by race.

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“…Unfortunately, these correcting methods introduce other errors into the interpretation of the IOP results. In addition, the adjusted IOP is unlikely to improve tonometry as a screening tool for open angle glaucoma (OAG) in at-risk populations [31] and is not necessary in population-based assessment [32]. Therefore, attempting to "correct" IOP based on CCT does not provide any benefit in the assessment or management in the glaucoma or glaucoma suspect patient.…”

Section: Artifact and Correctionmentioning

confidence: 99%

The thick and thin of the central corneal thickness in glaucoma

Belovay

Goldberg

2018

Eye

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Central corneal thickness (CCT) is an important parameter in the assessment of any potential glaucoma patient. While it affects prognosis in ocular hypertension, its value in patients diagnosed with glaucoma is less certain. There are several biological factors and genetic components that may influence glaucoma progression, which have been associated with thinner CCT. The CCT itself can be affected by several factors including ethnicity, age, sex, glaucoma medications, genetics, and the subtype of glaucoma. Besides, there is variability in the measurement of CCT between difference types of devices. These factors need to be considered in the evaluation of glaucoma patients' CCT and its effect on interpretation of intraocular pressure levels and risk stratification.

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Intraocular pressure adjusted for central corneal thickness as a screening tool for open-angle glaucoma in an at-risk population

Cited by 8 publications

References 30 publications

The Association of Meibomian Gland Dysfunction and Other Common Ocular Diseases With Dry Eye: A Population-Based Study in Spain

The Association of Meibomian Gland Dysfunction and Other Common Ocular Diseases With Dry Eye: A Population-Based Study in Spain

Measuring accurate IOPs: Does correction factor help or hurt?

The thick and thin of the central corneal thickness in glaucoma

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