Intraocular pressure and progression in exfoliative eyes with ocular hypertension or glaucoma

Harju, Mika

doi:10.1034/j.1600-0420.2000.078006699.x

Cited by 10 publications

(6 citation statements)

References 14 publications

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“…This increased risk was an expected finding, being consistent with the more severe clinical course of exfoliation glaucoma. 39 Since persons with this type of glaucoma have higher IOP than others, 40 their increased risk could be attributed, at least in part, to the elevated IOP. In fact, 20 of the 23 EMGT patients with exfoliation had an IOP of 21 mm Hg or more.…”

Section: Exfoliationmentioning

confidence: 99%

Factors for Glaucoma Progression and the Effect of Treatment

Leske

Heijl

Hussein³

et al. 2003

Arch Ophthalmol

1,793

513

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Setting/Participants: Two hundred fifty-five openangle glaucoma patients randomized to argon laser trabeculoplasty plus topical betaxolol or no immediate treatment (129 treated; 126 controls) and followed up every 3 months. Methods: Progression was determined by perimetric and photographic optic disc criteria. Patient-based risk of progression was evaluated using Cox proportional hazard regression models and was expressed as hazard ratios (HR) with 95% confidence intervals (95% CI). Results: After 6 years, 53% of patients progressed. In multivariate analyses, progression risk was halved by treatment (HR = 0.50; 95% CI, 0.35-0.71). Predictive baseline factors were higher intraocular pressure (IOP) (ie, the higher the baseline IOP, the higher the risk), exfoliation, and having both eyes eligible (each of the latter 2 factors doubled the risk), as well as worse mean deviation and older age. Progression risk decreased by about 10% with each millimeter of mercury of IOP reduction from baseline to the first follow-up visit (HR=0.90 per millimeter of mercury decrease; 95% CI, 0.86-0.94). The first IOP at that visit (3 months' follow-up) was also related to progression (HR = 1.11 per millimeter of mercury higher; 95% CI, 1.06-1.17), as was the mean IOP at follow-up (HR=1.13 per millimeter of mercury higher; 95% CI, 1.07-1.19). The percent of patient follow-up visits with disc hemorrhages was also related to progression (HR=1.02 per percent higher; 95% CI, 1.01-1.03). No other factors were identified. Conclusions: Patients treated in the EMGT had half of the progression risk of control patients. The magnitude of initial IOP reduction was a major factor influencing outcome. Progression was also increased with higher baseline IOP, exfoliation, bilateral disease, worse mean deviation, and older age, as well as frequent disc hemorrhages during follow-up. Each higher (or lower) millimeter of mercury of IOP on follow-up was associated with an approximate 10% increased (or decreased) risk of progression.

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Section: Exfoliationmentioning

confidence: 99%

Factors for Glaucoma Progression and the Effect of Treatment

Leske

Heijl

Hussein³

et al. 2003

Arch Ophthalmol

1,793

513

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“…It has been assumed that it is present in approximately 25% of cases of open-angle glaucoma worldwide [23]. Some individuals with XS may show progression to glaucoma [6]. Among the group of patients with XS, the individuals with high intraocular pressure (IOP) values are more inclined to glaucoma on long-term follow-up than patients without XS.…”

Section: Introductionmentioning

confidence: 99%

Diurnal variation of intraocular pressure and its correlation with retinal nerve fiber analysis in Turkish patients with exfoliation syndrome

Gümüş

Bozkurt

Sönmez

et al. 2005

Graefe's Arch Clin Exp Ophthalmo

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“…Iako je učestalost kapsularnog glaukoma u našem uzorku bila češća kod žena 14 (13,4 %) u odnosu na muškarce 11 (10,4 %), statistički značajna razlika u odnosu na pol nije zapažena (p = 0,352). Binokularni oblik ispojavanja kapsularnog glaukoma je češći od monokularnog oblika u kome drugo oko može biti zdravo-nezahvaćeno ili zahvaćeno nekim drugim tipom glaukoma (34,35). Rezultati naše studije govore da se binokularni oblik kapsularnog glaukoma javlja 3,7 puta češće od monokularnog oblika kod žena u ispitivanom uzorku, dok je kod muškaraca binokularni oblik 1,7 puta češći u odnosu na monokularni.…”

Section: Diskusijaunclassified

“…Inicijalni pristup u lečenju kapsularnog glaukoma podrazumeva primenu medikamentne terapije (35). Ipak, treba naglasiti da je lečenje ovog tipa glaukoma teže u poređenju sa primarnim glaukomom otvorenog ugla (36,37 regulacije IOP-a upotrebom medikamenata, veći uspeh može se postići sprovođenjem operativnog lečenja (38,39).…”

Section: Diskusijaunclassified

Pseudoexfoliation glaucoma: Always actual problem in ophthalmology

Vasović¹,

Markovic²

2018

Medicinski podmladak

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Introduction: Pseudoexfoliation (PEX) syndrome is not only an ocular disease but also a general disorder that involves the abnormal production and disposal of extracellular matrix material in intra-and extraocular tissues. Intraocular pressure (IOP) of the pseudoexfoliative eyes is higher than IOP of the nonpseudoexfoliative eyes which leads to more severe eye damage during longer period of time. Glaucoma in the pseudoexfoliation syndrome has been shown to have a more serious clinical course than in primary open-angle glaucoma. Aim: The aim of our study was to determine the presence and frequency of capsular glaucoma compared to other types of glaucoma among patients examined in one month period and in total number of glaucoma operated patients during last year. Materials and methods: Our study involved 105 patients examined and diagnosed in November 2016 and 346 glaucoma patients operated between January and October 2016 at Clinic for eye diseases, Clinical Centre of Serbia. Methods used in examination and monitoring of patients were: biomicroscopy, applanation tonometry, computerized perimetry, ophthalmoscopy, gonioscopy and Heidelberg Retinal Tomography II. Results: Although the frequency of capsular glaucoma in our sample was more common in women 14 (13.4 %) compared to men 11 (10.4 %), statistically significant difference related to sex was not observed (p = 0.352). Binocular expression was 3.7 times more often than monocular in women and 1.7 times in men. Among glaucoma operated patients, capsular glaucoma was found in 94 (27.2 %) cases, which leads to conclusion that every fourth patient operated last year had this type of glaucoma. Conclusion: Based on the results of our study it can be concluded that capsular glaucoma, as the most important ocular manifestation of PEX syndrome, shows high frequency in our population. Careful clinical examination should be performed in patients over the age of 50 due to the importance of early recognition and appropriate management of pseudoexfoliative material in the eye.

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Intraocular pressure and progression in exfoliative eyes with ocular hypertension or glaucoma

Abstract: ABSTRACT.Purpose: This retrospective study was conducted in exfoliative eyes in order to study the influence of IOP and other possible factors on the conversion from ocular hypertension (OHT) to glaucoma and progression of glaucoma.

Cited by 10 publications

References 14 publications

Factors for Glaucoma Progression and the Effect of Treatment

Factors for Glaucoma Progression and the Effect of Treatment

Diurnal variation of intraocular pressure and its correlation with retinal nerve fiber analysis in Turkish patients with exfoliation syndrome

Pseudoexfoliation glaucoma: Always actual problem in ophthalmology

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