Intraocular pressure elevation and choroidal thinning

Wang, Ya Xing; Jiang, Ruming; Ren, Xiao Lei; Chen, Jian Dong; Shi, Hongbo; Xu, Liang; Wei, Wen Bin; Jonas, Jost B

doi:10.1136/bjophthalmol-2015-308062

Cited by 32 publications

(20 citation statements)

References 25 publications

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“…Such a finding would agree with a previous histomorphometric study in which the choroid was significantly thinner in eyes with chronic angle-closure glaucoma than in a control group 30 . It would also agree with a recent investigation in which eyes with increases in intraocular pressure in a dark room adaptation test showed thinning of the choroid 31 . This finding is also in partial contrast to the results of studies on eyes with acute angle-closure glaucoma in which an abnormally thick choroid was reported 9 , 10 .…”

Section: Discussionsupporting

confidence: 93%

Macular Choroidal Small-Vessel Layer, Sattler’s Layer and Haller’s Layer Thicknesses: The Beijing Eye Study

Zhao

Wang

Zhang

et al. 2018

Sci Rep

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To study macular choroidal layer thickness, 3187 study participants from the population-based Beijing Eye Study underwent spectral-domain optical coherence tomography with enhanced depth imaging for thickness measurements of the macular small-vessel layer, including the choriocapillaris, medium-sized choroidal vessel layer (Sattler’s layer) and large choroidal vessel layer (Haller’s layer). In multivariate analysis, greater thickness of all three choroidal layers was associated (all P < 0.05) with higher prevalence of age-related macular degeneration (AMD) (except for geographic atrophy), while it was not significantly (all P > 0.05) associated with the prevalence of open-angle glaucoma or diabetic retinopathy. There was a tendency (0.07 > P > 0.02) toward thinner choroidal layers in chronic angle-closure glaucoma. The ratio of small-vessel layer thickness to total choroidal thickness increased (P < 0.001; multivariate analysis) with older age and longer axial length, while the ratios of Sattler’s layer and Haller’s layer thickness to total choroidal thickness decreased. A higher ratio of small-vessel layer thickness to total choroidal thickness was significantly associated with a lower prevalence of AMD (early type, intermediate type, late geographic type). Axial elongation-associated and aging-associated choroidal thinning affected Haller’s and Sattler’s layers more markedly than the small-vessel layer. Non-exudative and exudative AMD, except for geographic atrophy, was associated with slightly increased choroidal thickness.

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Section: Discussionsupporting

confidence: 93%

Macular Choroidal Small-Vessel Layer, Sattler’s Layer and Haller’s Layer Thicknesses: The Beijing Eye Study

Zhao

Wang

Zhang

et al. 2018

Sci Rep

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“…The observation made in our study, however, fits with the result of a recent study on patients who developed an increased intra‐ocular pressure after spending 2 hr in a dark room adaptation test and who showed a thinning of the choroid (Wang et al. ). The finding that the neither SMVL‐to‐LVL thickness ratio nor the thickness of the choroidal layers taken separately were significantly associated with the prevalence of open‐angle glaucoma, AMD, DR and retinal vein occlusions supports the notion that peripapillary choroidal thickness may not be correlated with the prevalence of these disorders (Xu et al.…”

Section: Discussionsupporting

confidence: 92%

Peripapillary choroidal vascular layers: the Beijing Eye Study

Wang

Jiang

et al. 2017

Acta Ophthalmologica

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Small-to-medium vessel layer (SMVL) and LVL, thickest superiorly and thinnest inferiorly, increased with younger age and higher cognitive function after adjusting for axial length and prevalence of angle-closure glaucoma. With older age, longer axial length, larger optic disc area and larger β zone, LVL decreased more than SMVL in thickness. The association between thicker peripapillary choroidal thickness and better cognitive function may deserve further attention.

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“…All these factors may exert an effect on the results obtained. Many studies confirmed the effect of such factors as age, gender, axial length of the eye (AL), refraction defect, CCT, or the IOP level of the choroidal thickness [ 30 – 32 ]. A comprehensive study concerning the evaluation of the subfoveal choroidal thickness (SFCT) which covered 3,233 patients showed that the SFCT is higher in younger individuals, in shorter eyeballs, in males, in eyes with a deeper anterior chamber, thicker lens, flat retina, and better best corrected visual acuity (BCVA).…”

Section: Discussionmentioning

confidence: 99%

Choroidal Thickness in Women with Uncomplicated Pregnancy: Literature Review

Roskal-Wałek

Laudańska-Olszewska²,

Biskup

et al. 2017

BioMed Research International

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Pregnancy is a time when many changes occur in a woman's body. The goal of these changes is the provision of optimum conditions for the development of the foetus. Pregnancy also affects eye physiology. Well recognized physiological changes include a reduced corneal sensitivity, an increase in its central thickness and curvature, and a decrease in intraocular pressure. The association between choroidal thickness and pregnancy is not clear. Haemodynamic and hormonal changes taking place during pregnancy and the question of whether these changes are reflected by choroidal thickness are especially important. It is assumed that the choroid, which is one of the most highly vascularized tissues characterized by the highest blood flow to tissue volume ratio in the whole body, should respond by an increase in its thickness to an increase in blood flow and drop in the value of peripheral resistance. Measurement of choroidal thickness using enhanced depth imaging optical coherence tomography (EDI-OCT) in women with uncomplicated pregnancy provides important information concerning the effects of physiological changes in the eye.

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Intraocular pressure elevation and choroidal thinning

Abstract: Choroidal thickness in the subfoveal region and in the peripapillary region decreased parallel to an acute increase in IOP in individuals 2 h after a dark room test. Choroidal thickness depends on the actual IOP, which may be noted when choroidal thickness is measured.

Cited by 32 publications

References 25 publications

Macular Choroidal Small-Vessel Layer, Sattler’s Layer and Haller’s Layer Thicknesses: The Beijing Eye Study

Macular Choroidal Small-Vessel Layer, Sattler’s Layer and Haller’s Layer Thicknesses: The Beijing Eye Study

Peripapillary choroidal vascular layers: the Beijing Eye Study

Choroidal Thickness in Women with Uncomplicated Pregnancy: Literature Review

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