Intraocular pressure in schizophrenic patients treated with psychiatric medications

Abstract

Purpose: In order to assess the occurrence of adverse ocular effects of antipsychotic drugs, we sought to evaluate intraocular pressure of schizophrenic patients treated with psychiatric medications. Methods: Twenty-eight outpatients with DSM-IV diagnosis of schizophrenia who met both the inclusion and exclusion criteria were submitted to an ophthalmic evaluation for ocular abnormalities which included intraocular pressure measurement with Goldmann applanation tonometry. Results: Raised intraocular pressure was found in three patients (11%). Abnormality in cup-disc ratio was seen in only one patient with cup-disc ratio asymmetry of 0.4. All these four patients were taking only ziprasidone. Conclusions: Patients using ziprasidone were found to have abnormalities in both intraocular pressure and cup-disc ratio. ABSTRACT INTRODUCTION

Psychopharmacological Treatment, Intraocular Pressure and the Risk of Glaucoma: A Review of Literature

“…A cross-sectional study including 28 patients with schizophrenia showed that individuals under typical antipsychotics treatment had normal IOP [79]. This result is similar to the one reported by Reid et al (1976).…”

“…Some other actions include the inhibition of muscarinic receptors (anticholinergic activity). A possible explanation for the association between antipsychotic drugs and glaucoma might be the cholinergic receptor blockade (muscarinic) [34,79] (Table 1, Figure 1).…”

Optical coherence tomography indices of structural retinal pathology in schizophrenia

“…Related to this, some types of antipsychotic and antidepressant medications commonly given to people with schizophrenia act as serotonin agonists (e.g. ziprasidone, selective serotonin reuptake inhibitors) and this can raise intra-ocular pressure and lead to glaucoma, which could contribute to changes in optic nerve parameters (Souza et al 2008) even prior to criteria for glaucoma being met.…”

Psikotropik İlaçlar ve Oküler Yan Etkileri

“…20 In a study done with schizophrenic patients using antipsychotics, abnormalities in the intraocular pressure and optical disc cavitation ratios have been determined in users of ziprasidone. 21 In the literature, there is a case of transient myopia induced by aripiprazole. 22 When the atypical antipsychotics are compared to typical ones, dystonic reactions and therefore cause of oculogyric crisis are not expected.…”