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Purpose: In order to assess the occurrence of adverse ocular effects of antipsychotic drugs, we sought to evaluate intraocular pressure of schizophrenic patients treated with psychiatric medications. Methods: Twenty-eight outpatients with DSM-IV diagnosis of schizophrenia who met both the inclusion and exclusion criteria were submitted to an ophthalmic evaluation for ocular abnormalities which included intraocular pressure measurement with Goldmann applanation tonometry. Results: Raised intraocular pressure was found in three patients (11%). Abnormality in cup-disc ratio was seen in only one patient with cup-disc ratio asymmetry of 0.4. All these four patients were taking only ziprasidone. Conclusions: Patients using ziprasidone were found to have abnormalities in both intraocular pressure and cup-disc ratio. ABSTRACT INTRODUCTION

IntroductionHypoparathyroidism (HP) is a rare endocrine disease and there are little data available on the risk of fragility fractures in these patients. PTH deficiency results in a positive bone balance with higher bone mass in all skeletal sites. However, whether these structural and dynamic skeletal changes have a negative impact on the fracture risk, it is not known.MethodsAiming to investigate the risk of insufficiency vertebral fractures in HP, defined using morphometric criteria, a consecutive sampling of 44 women with chronic postsurgical HP was compared to a control group of 44 adult healthy women, matched by age with patients. Vertebral fractures were analyzed by the semiquantitative Genant’s method followed by quantitative vertebral morphometry.ResultsMorphometric vertebral fractures were identified in 5/44 (11.4%) patients and in 3/44 (6.8%) controls (p=0.731). Most fractures were classified as Genant II and III grades in HP patients, whereas most were Genant I in controls. A logistic regression multivariate analysis was conducted in which age, BMI and parathyroid status were the independent variables, and morphometric vertebral fracture was the dependent variable, but none of these factors was a significant predictor of fracture in this population (OR 1.01, 95% CI 0.96-1.07, p=0.634 for age; OR 2.24, 95%CI 0.47-10.50, p=0.306 for the presence/absence of HP and OR 0.92, 95% CI 0.76-1.10, p=0.369 for BMI).ConclusionThe results of this study cannot ensure a higher risk of fragility vertebral fractures in postsurgical HP patients. Instead, we only observed higher Genant grade classification of the deformed vertebrae in our sample.

O rim é o terceiro órgão mais acometido em pacientes vítimas de trauma abdominal. A maioria das lesões traumáticas renais são pequenas, sendo tratadas conservadoramente.  A indicação absoluta de tratamento cirúrgico é reservada à menor parte dos casos (< 5%). A tomografia computadorizada é a ferramenta diagnóstica mais importante para adequada avaliação da lesão renal e classificação segundo os critérios da Associação Americana para a Cirurgia do Trauma (AAST). No presente estudo, nós descrevemos os achados tomográficos de cinco pacientes vítimas de trauma renal atendidos em um hospital terciário de referência em trauma e emergência do estado do Ceará e classificamos as lesões renais encontradas segundo os critérios da AAST.