Intraocular soluble IL-2 receptor alpha in a patient with adult T cell leukaemia with intraocular invasion

Sugita, Sunao

doi:10.1136/bjo.2006.092809

Cited by 8 publications

(6 citation statements)

References 7 publications

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“…21 Several groups have reported vitreous opacities due to ATL cell infiltration. 9,2023–25 ATL patients also present with anterior uveitis. Iritis, cyclitis, aqueous cells and flare, keratic precipitates, and synechiae are common manifestations.…”

Section: Case Reportmentioning

confidence: 99%

“… 23 Retinal sheathing, venous dilation and vasculitis, edema, folds, lesions, and exudates with cotton wool spots have also been seen. 24 , 25 , 27 Additionally, the retina may be affected by opportunistic infections such as cytomegalovirus retinitis. Such a case has been reported, and histological analysis showed cytomegalic cell infiltration and widespread retinal necrosis and disorganization.…”

Section: Case Reportmentioning

confidence: 99%

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Ocular Manifestations and Pathology of Adult T-cell Leukemia/Lymphoma Associated with Human T-lymphotropic virus Type 1

et al. 2010

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The human T-cell lymphotropic virus type 1 (HTLV-1), endemic in defined geographical areas around the world, is recognized as the etiologic agent of adult T-cell leukemia/lymphoma (ATL), or HTLV-1. ATL is a rare adult onset T-cell malignancy that is characterized by the presence of ATL flower cells with T-cell markers, HTLV-1 antibodies in the serum, and monoclonal integration of HTLV-1 provirus in affected cells. Ocular manifestations associated with HTLV-1 virus infection have been reported and include HTLV-1 uveitis and keratoconjunctivitis sicca, but reports of ocular involvement in ATL are exceedingly rare. This article describes the ocular manifestations and pathology of ATL. We also report for the first time a case of a 34-year-old male with systemic ATL and prominent atypical lymphoid cell infiltration in the choroid. To our knowledge, this is the first report defining prominent choroidal involvement as a distinct ocular manifestation of ATL. ATL may masquerade as a variety of other conditions, and molecular techniques involving microdissection and PCR have proven to be critical diagnostic tools. International collaboration will be needed to better understand the presentation and diagnosis of this rare malignancy.

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Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Ocular Manifestations and Pathology of Adult T-cell Leukemia/Lymphoma Associated with Human T-lymphotropic virus Type 1

et al. 2010

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“…The diversity in clinical features and prognosis of patients with ATL has led to its subclassification into the following 4 subtypes: smoldering, chronic, acute leukemic forms, and ATL lymphoma [ 3 ]. Rare cases with intraocular invasion of acute-type ATL have been reported [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Intraocular Invasion of Adult T-Cell Leukemia Cells without Systemic Symptoms after Cataract Surgery

Maruyama

Nagata

Kojima

et al. 2013

Case Rep Ophthalmol

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Adult T-cell leukemia (ATL) is an aggressive lymphoid proliferation associated with the human T-lymphotropic virus type I (HTLV-I). The intraocular invasion of ATL is a rare event. A 75-year-old man without any systemic disease underwent uneventful cataract surgery of the right eye. On postoperative day 6, the patient presented with blurred vision due to severe vitreous opacity in the right eye. Analysis of the vitreous fluid revealed a suspected ATL infection based on the flow cytometric analysis. Moreover, cytological examination of the vitreous specimen revealed flower cell infiltration, and HTLV-1 DNA was detected by PCR analysis of the vitreous sample. Monoclonal T-cell receptor chain rearrangement was also detected by PCR. Thorough analysis of a vitreous sample is essential for vitrectomy in vitreous opacity of unknown cause. Flow cytometric, cytological, and PCR analysis of vitreous samples is beneficial for determining the cause of this kind of severe illness.

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“…PubMed was also searched for the key words “adult T-cell leukemia/lymphoma” and “ocular” or “adult T-cell leukemia/lymphoma” and “eye.” The sufficient description was found in 16 Japanese patients who showed pathologically proven intraocular infiltration with ATLL ( Table 1 ). 7 - 22…”

Section: Methodsmentioning

confidence: 99%

“…In this study, we present 2 patients with pathologically proven intraocular infiltration with ATLL: one patient with vitreous opacity in both eyes and the other patient with aqueous hypopyon (pseudohypopyon) in the right eye. In addition, we reviewed 16 patients of pathologically proven intraocular infiltration with ATLL in the literature [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] to answer a clinical question when would be the timing of intraocular infiltration in the course of the disease.…”

mentioning

confidence: 99%

Pathologically Proven Intraocular Infiltration With Adult T-Cell Leukemia/Lymphoma: Two New Cases With Either Vitreous Opacity or Aqueous Hypopyon and Literature Review of 16 Cases

Matsuo

Shimizu

Tanaka

et al. 2020

Journal of Investigative Medicine High Impact Case Reports

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This study reported 2 new patients and 16 historical cases with pathologically proven intraocular infiltration with adult T-cell leukemia and lymphoma (ATLL) to know the timing of intraocular infiltration in the disease course. The first case was a 67-year-old woman who developed bilateral vitreous opacity about half a year after the onset of acute type of ATLL that had been unresponsive to chemotherapy. She underwent vitrectomy combined with cataract surgery in both eyes. She had bilateral optic disc atrophy and localized retinal white infiltrates in both eyes. Cytological examination of vitreous aspirates demonstrated medium-sized cells with aberrant flower-like convoluted nuclei, positive for CD3, and thus indicative of T-cells. The second case was a 38-year-old man who was diagnosed acute type of ATLL at the presentation of acute kidney injury. About half a year after initial chemotherapy and allogeneic hematopoietic stem cell transplantation, he developed aqueous hypopyon in the right eye, concurrent with cutaneous and central nervous system relapse. Aqueous tap disclosed class V abnormal cells. The aqueous “pseudohypopyon” resolved in response to another round of chemotherapy with mogamulizumab. In review of 18 patients, intraocular infiltration with ATLL was diagnosed by vitrectomy in 9, aqueous tap in 3, chorioretinal biopsy in 3, and autopsy in 3. The intraocular infiltration developed concurrently with systemic diagnosis of ATLL in 5 patients, but developed later after chemotherapy in 13. In conclusion, intraocular infiltration with ATLL appears rare, and pathological diagnosis by vitrectomy and aqueous tap would help determine therapeutic plan in relapse after chemotherapy.

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Intraocular soluble IL-2 receptor alpha in a patient with adult T cell leukaemia with intraocular invasion

Cited by 8 publications

References 7 publications

Ocular Manifestations and Pathology of Adult T-cell Leukemia/Lymphoma Associated with Human T-lymphotropic virus Type 1

Ocular Manifestations and Pathology of Adult T-cell Leukemia/Lymphoma Associated with Human T-lymphotropic virus Type 1

Intraocular Invasion of Adult T-Cell Leukemia Cells without Systemic Symptoms after Cataract Surgery

Pathologically Proven Intraocular Infiltration With Adult T-Cell Leukemia/Lymphoma: Two New Cases With Either Vitreous Opacity or Aqueous Hypopyon and Literature Review of 16 Cases

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