Intraoperative 125I brachytherapy for high-risk stage I non-small cell lung carcinoma

Chen, Alex; Galloway, Michael; Landreneau, Rodney; d’Amato, Thomas A.; Colonias, Athanasios; Karlovits, Stephen; Quinn, Annette; Santucci, Tibetha; Kalnicki, Shalom; Brown, Douglas M.

doi:10.1016/s0360-3016(99)00133-9

Cited by 63 publications

(40 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Intraoperative brachytherapy with radioactive iodine-125 ( 125 I) seed implantation has been proven to be an effective therapeutic modality and an alternative to external beam radiation therapy (EBRT) for patients with lung cancer (3)(4)(5)(6). However, intraoperative 125 I seed implantation requires an open-chest approach, which may result in more prolonged hospitalization and a significant economic burden for the patients.…”

Section: Introductionmentioning

confidence: 99%

Computed tomography fluoroscopy-guided percutaneous 125I seed implantation for safe, effective and real-time monitoring radiotherapy of inoperable stage T1-3N0M0 non-small-cell lung cancer

Xiao

et al. 2013

Molecular and Clinical Oncology

View full text Add to dashboard Cite

Abstract. The management of inoperable lung cancer remains a challenge. It has been proven that computed tomography (CT)-guided iodine-125 ( 125 I) seed implantation is a safe and efficient method for treating lung cancer. Computed tomographic fluoroscopy (CTF) is superior to traditional CT for percutaneous management of lung lesions, due to the real-time guidance and accurate localization of the lesions. The aim of the present prospective study was to evaluate the feasibility, safety and efficacy of CTF-guided percutaneous permanent implantation of 125 I seeds for the treatment of selected patients with inoperable stage T1-3N0M0 non-small-cell lung cancer (NSCLC). A total of 24 patients with resectable but inoperable stage T1-3N0 NSCLC, with a total of 28 lesions, underwent CTF-guided percutaneous implantation of radioactive 125 I seeds. A prescription dose of 100-120 Gy was delivered to each lesion. The complications and local tumor control rates were documented. Survival was estimated using the Kaplan-Meier method. All the patients successfully completed the procedure, with a mean procedure duration of 45.7 min (range, 30-75 min). No severe complications occurred. Small asymptomatic pneumothorax with lung volume compression of <10% and minor hemorrhage along the needle track without hemoptysis occurred immediately after the procedure in 3 (12.5%) and 4 (16.7%) of the 24 patients, respectively. At a median follow-up of 31.5 months (range, 8-46 months), the local control rate (LCR) of the lesions was 78.6% (22/28). The 1-, 2-and 3-year overall survival rate was 95.8, 78 and 55%, respectively. In conclusion, CTF is the favourable imaging guidance method for the percutaneous implantation of 125 I seeds. CTF-guided brachytherapy with implantation of 125 I seeds is a safe, feasible and effective modality for the treatment of inoperable early-stage NSCLC and may be considered an alternative option in selected patients with medically inoperable NSCLC.

show abstract

Section: Introductionmentioning

confidence: 99%

Computed tomography fluoroscopy-guided percutaneous 125I seed implantation for safe, effective and real-time monitoring radiotherapy of inoperable stage T1-3N0M0 non-small-cell lung cancer

Xiao

et al. 2013

Molecular and Clinical Oncology

View full text Add to dashboard Cite

show abstract

“…After promising results, we will further evaluate interventional brachytherapy as an additional tool in multimodal oncologic therapy concepts (Chen et al, 1999;Trombetta et al, 2008). This study suggested that image-guided brachytherapy using 125 I seeds implantation appeared to be safe, effective, uncomplicated, and could produce adequate pain relief for treating unresectable pancreatic cancer.…”

Section: Wwwintechopencommentioning

confidence: 95%

Clinical Application of Image-Guided Iodine-125 Seed Implantation Therapy in Patients with Advanced Pancreatic Cancer

Wang¹,

Chen²

2011

Current Cancer Treatment - Novel Beyond Conventional Approaches

View full text Add to dashboard Cite

“…The recent increase in MIS has also renewed an interest in the role of adjuvant brachytherapy for lung cancer [52][53][54][55][56][57][58][59]. Following resection of small lung tumours (T1N0), intraoperative I-125 seeds have been implanted with Vicryl ® mesh along the resection margins [52,53,57].…”

Section: Adjuvant Brachytherapy For Lung Cancermentioning

confidence: 99%

“…Following resection of small lung tumours (T1N0), intraoperative I-125 seeds have been implanted with Vicryl ® mesh along the resection margins [52,53,57]. The technique appears to be safe and appears to reduce local tumour recurrence rates, but long-term results are required.…”

Section: Adjuvant Brachytherapy For Lung Cancermentioning

confidence: 99%

Lung Cancer Brachytherapy: Robotics-Assisted Minimally Invasive Approach

Yu¹,

Lewis²,

Trejos³

et al. 2011

CRMR

View full text Add to dashboard Cite

New technological concepts have been evolving to manage the relative poor prognosis of lung cancer. Brachytherapy is becoming an option for both unresectable and early resectable lung cancer. Three-dimensional ultrasound (US) of lung tumours and image-guided minimally invasive robotics-assisted brachytherapy are feasible for dosimetry planning and management of lung tumours. The present article reviews the current knowledge of lung brachytherapy and discusses its potential in future management of lung cancer.

show abstract

Intraoperative 125I brachytherapy for high-risk stage I non-small cell lung carcinoma

Cited by 63 publications

References 37 publications

Computed tomography fluoroscopy-guided percutaneous 125I seed implantation for safe, effective and real-time monitoring radiotherapy of inoperable stage T1-3N0M0 non-small-cell lung cancer

Computed tomography fluoroscopy-guided percutaneous 125I seed implantation for safe, effective and real-time monitoring radiotherapy of inoperable stage T1-3N0M0 non-small-cell lung cancer

Clinical Application of Image-Guided Iodine-125 Seed Implantation Therapy in Patients with Advanced Pancreatic Cancer

Lung Cancer Brachytherapy: Robotics-Assisted Minimally Invasive Approach

Contact Info

Product

Resources

About