Intraoperative electron beam radiation therapy: Technique, dosimetry, and dose specification: Report of task force 48 of the radiation therapy committee, American Association of Physicists in Medicine

Palta, Jatinder; Biggs, Peter J.; Hazle, John D.; Huq, M. Saiful; Dahl, Robert A.; Ochran, Timothy G.; Soen, J; Dobelbower, Ralph R.; McCullough, Edwin C.

doi:10.1016/0360-3016(95)00280-c

Cited by 75 publications

(64 citation statements)

References 51 publications

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“…For the bevelled applicators, the PDD curves were obtained along the "clinical axis", as recommended by the American Association of Physicists in Medicine task group 48. 6 The clinical axis is defined by a line perpendicular to the phantom surface and intersecting the applicator central axis at the surface, 6 as shown in Figure 1a. For simplicity, this is referred to in the text as central axis.…”

Section: Linac Systemmentioning

confidence: 99%

“…International guidelines recommend prescription to the 90% isodose for adequate tumour coverage, but give no indications of acceptable uncertainties. 6 Treatment outcomes have been assessed in several studies, 7,8 but cannot be correlated with patient-specific dose distributions. In this context, it is necessary to first determine how frequently step-like surfaces occur in clinical practice and how great is the effect of clinically occurring irregularities on the dose distributions.…”

Section: Introductionmentioning

confidence: 99%

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In vivodosimetry using Gafchromic films during pelvic intraoperative electron radiation therapy (IOERT)

Costa¹,

Sarmento²,

Gomes³

et al. 2016

BJR

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Objective: To characterize in vivo dose distributions during pelvic intraoperative electron radiation therapy (IOERT) for rectal cancer and to assess the alterations introduced by irregular irradiation surfaces in the presence of bevelled applicators. Methods: In vivo measurements were performed with Gafchromic films during 32 IOERT procedures. 1 film per procedure was used for the first 20 procedures. The methodology was then optimized for the remaining 12 procedures by using a set of 3 films. Both the average dose and two-dimensional dose distributions for each film were determined. Phantom measurements were performed for comparison. Results: For flat and concave surfaces, the doses measured in vivo agree with expected values. For concave surfaces with step-like irregularities, measured doses tend to be higher than expected doses. Results obtained with three films per procedure show a large variability along the irradiated surface, with important differences from expected profiles. These results are consistent with the presence of surface hotspots, such as those observed in phantoms in the presence of step-like irregularities, as well as fluid build-up. Conclusion: Clinical dose distributions in the IOERT of rectal cancer are often different from the references used for prescription. Further studies are necessary to assess the impact of these differences on treatment outcomes. In vivo measurements are important, but need to be accompanied by accurate imaging of positioning and irradiated surfaces. Advances in knowledge: These results confirm that surface irregularities occur frequently in rectal cancer IOERT and have a measurable effect on the dose distribution.

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Section: Linac Systemmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vivodosimetry using Gafchromic films during pelvic intraoperative electron radiation therapy (IOERT)

Costa¹,

Sarmento²,

Gomes³

et al. 2016

BJR

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“…The lack of such tools has limited the spread and acceptance of this technique (16,17). Our work contributes to the solution of simulation and preplanning needs, demonstrating the system in several real clinical cases with encouraging results.…”

Section: Discussionmentioning

confidence: 98%

An Innovative Tool for Intraoperative Electron Beam Radiotherapy Simulation and Planning: Description and Initial Evaluation by Radiation Oncologists

Pascau

Miranda

Calvo

et al. 2012

International Journal of Radiation Oncology*Biology*Physics

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SummaryThe lack of specific treatment planning tools limits the spread of Intraoperative Electron Radiation Therapy. An innovative simulation and planning tool is presented. Applicator positioning, isodose curves, and dose volume histograms can be estimated for previously segmented regions to treat/protect. Evaluation by three radiation oncologists on 15 patients showed high parameter agreement in nine cases, demonstrating the possibilities in cases involving different anatomical locations, and Purpose: Intraoperative electron beam radiation therapy (IOERT) involves a modified strategy of conventional radiation therapy and surgery. The lack of specific planning tools limits the spread of this technique. The purpose of the present study is to describe a new simulation and planning tool and its initial evaluation by clinical users. Methods and Materials: The tool works on a preoperative computed tomography scan. A physi cian contours regions to be treated and protected and simulates applicator positioning, calcu lating isodoses and the corresponding doseevolume histograms depending on the selected electron energy. Three radiation oncologists evaluated data from 15 IOERT patients, including different tumor locations. Segmentation masks, applicator positions, and treatment parameters were compared. Results: High parameter agreement was found in the following cases: three breast and three rectal cancer, retroperitoneal sarcoma, and rectal and ovary monotopic recurrences. All radiation oncologists performed similar segmentations of tumors and high risk areas. The average appli cator position difference was 1.2 AE 0.95 cm. The remaining cancer sites showed higher devia tions because of differences in the criteria for segmenting high risk areas (one rectal, one pancreas) and different surgical access simulated (two rectal, one Ewing sarcoma). Conclusions:The results show that this new tool can be used to simulate IOERT cases involving different anatomic locations, and that preplanning has to be carried out with specialized surgical input.

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“…For the Output measurements, in no reference conditions and in particular in the case of small and or beveled applicators, a solid phantom and radiographic or radiochromic films (Fiandra et al, 2008), or TLD (Palta et al, 1995) may be employed.…”

Section: Dosimetry Of the Beammentioning

confidence: 99%

Intra-Operative Radiotherapy with Electron Beam

Lamanna¹,

Gallo²,

Russo³

et al. 2012

Modern Practices in Radiation Therapy

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Intraoperative electron beam radiation therapy: Technique, dosimetry, and dose specification: Report of task force 48 of the radiation therapy committee, American Association of Physicists in Medicine

Cited by 75 publications

References 51 publications

In vivodosimetry using Gafchromic films during pelvic intraoperative electron radiation therapy (IOERT)

In vivodosimetry using Gafchromic films during pelvic intraoperative electron radiation therapy (IOERT)

An Innovative Tool for Intraoperative Electron Beam Radiotherapy Simulation and Planning: Description and Initial Evaluation by Radiation Oncologists

Intra-Operative Radiotherapy with Electron Beam

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