Intraoperative Fluorescence Visualization in Thoracoscopic Surgery

Huang, Weiyuan; Wang, Kun; Chen, Fengxia; Li, Gao; Chen, Xianshan; Yang, Qianyu; Li, Na; He, Kunshan; Chen, Feng; Tian, Jie

doi:10.1016/j.athoracsur.2022.03.040

Cited by 6 publications

(2 citation statements)

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“…In this study, inhalation of ICG was performed after anaesthesia, which was different from the case reported by Huang et al [ 15 ]. They described a method in which patient inhaled ICG aerosol autonomously.…”

Section: Discussionmentioning

confidence: 80%

“…Quan et al [ 14 ] reported ICG inhalation in mouse and rabbit tumour models as well as human lung specimens, indicating that inhalation at a 20-fold lower dose of ICG could achieve 2-fold higher efficiency for lung tumour detection than intravenous injection. Huang et al [ 15 ] reported a case that underwent preoperative ICG inhalation for visualization of pulmonary ground-glass opacity. However, to date, only preclinical studies or case reports of ICG inhalation have been published, and no cohort studies of intraoperative inhalation of fluorescent agents for pulmonary nodule localization in human have been reported.…”

Section: Introductionmentioning

confidence: 99%

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Indocyanine green inhalation visualizes lung tumour during video-assisted thoracoscopic surgery

Wang

Tian

Feng

et al. 2023

Interdisciplinary CardioVascular and Thoracic Surgery

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OBJECTIVES Accurate intraoperative identification of small lung tumours is crucial for precise resection of these lesions during video-assisted thoracoscopic surgery (VATS). This study aimed to evaluate the feasibility and safety of indocyanine green (ICG) inhalation for intraoperative visualization of lung tumours. METHODS From January 2022 to May 2022, 43 patients with lung nodules were included into this study. All patients received intraoperative ICG inhalation for visualization of lung tumours under near-infrared (NIR) imaging. The primary outcomes of this trial were the detection rate and background-tumour-ratio (BTR) of lung nodules, and the secondary objectives were time to search for nodules and operative time to nodules excision. RESULTS A total of 50 pulmonary nodules in 43 patients were identified and completely resected. And 44 lung nodules were detected during intraoperative fluorescent exploration with a median inhaled ICG dose of 18.8 mg. In vivo, the median BTR was 7.10. The median detection time of nodules was 100 seconds and the median operative time to nodules excision was 18 min. Quantification analysis showed that the fluorescence intensity of postoperative sputum declined to about 10% of the first fluorescent sputum within 20 hours. No adverse events attributed to ICG inhalation were recorded during the follow-up period. CONCLUSIONS Intraoperative inhalation of ICG was a feasible and safe method for detection of lung tumours at low dose of ICG. This technique could be a remedial measure for identification of unpalpable lung nodules without preoperative localization. Trial registration Chinese Clinical Trial Registry, Identifier: ChiCTR2100053708

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Section: Discussionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%