Intraoperative identification of sentinel lymph nodes by near-infrared fluorescence imaging in patients with breast cancer

Tagaya, Nobumi; Yamazaki, R.; Nakagawa, Aya; Abe, Akihito; Hamada, Kiyoshige; Kubota, Keiichi; Oyama, Tetsunari

doi:10.1016/j.amjsurg.2007.02.032

Cited by 217 publications

(192 citation statements)

References 10 publications

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“…4,5 Fluorescent labels have even been used to provide in vivo contrast during surgery, enabling, for instance, the detection of sentinel lymph nodes, and the complete resection of cancer tumors. [6][7][8] Fluorescence-assisted techniques have also been successfully applied to cardiovascular surgery procedures, organ transplantation, as well as controlled photothermal treatments. [9][10][11] All of these techniques require the use of optical probes that could act as contrast agents.…”

Section: Introductionmentioning

confidence: 99%

Neodymium-doped nanoparticles for infrared fluorescence bioimaging: The role of the host

Rosal

Pérez‐Delgado

Misiak

et al. 2015

Journal of Applied Physics

113

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The spectroscopic properties of different infrared-emitting neodymium-doped nanoparticles (LaF 3 :Nd 3þ , SrF 2 :Nd 3þ , NaGdF 4 : Nd 3þ , NaYF 4 : Nd 3þ , KYF 4 : Nd 3þ , GdVO 4 : Nd 3þ , and Nd:YAG) have been systematically analyzed. A comparison of the spectral shapes of both emission and absorption spectra is presented, from which the relevant role played by the host matrix is evidenced. The lack of a "universal" optimum system for infrared bioimaging is discussed, as the specific bioimaging application and the experimental setup for infrared imaging determine the neodymiumdoped nanoparticle to be preferentially used in each case. V C 2015 AIP Publishing LLC.

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Section: Introductionmentioning

confidence: 99%

Neodymium-doped nanoparticles for infrared fluorescence bioimaging: The role of the host

Rosal

Pérez‐Delgado

Misiak

et al. 2015

Journal of Applied Physics

113

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“…per groin, range [4][5][6][7][8][9][10][11][12][13][14], of which 109 were SLNs (mean 2.2 nodes (SD 1.4) per groin, range 1-7).…”

Section: Resultsmentioning

confidence: 99%

“…This ability to control the level of echelon nodes excised may prove an advantage over other developing novel techniques for SLNB, such as indocynanine green (ICG) fluorescence, in which studies have demonstrated the mean number of excised SLNs ranging from 1.75-5.4 for the same volume of 1 mL ICG administered. [12,23,24] Clinically, more than 2 mL of magnetic tracer has not been used. Furthermore, the nodal saturation point in humans is likely to be higher than that in mini-pigs.…”

Section: ]mentioning

confidence: 99%

“…[8] This figure drops to 5 per cent in China and is minimal in the rest of the world. [9] This has led to interest in the development of novel techniques not reliant upon radioisotopes (our Lancet reference in press -will be published by the time this is accepted) which are currently restricted uptake of dye by higher echelon nodes [10][11][12] and high false negative rates. [13] (This seems a nonsequitur -what does it mean?)…”

Section: Introductionmentioning

confidence: 99%

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160. Optimising magnetic sentinel lymph node biopsy in an in vivo porcine model

Ahmed

Anninga

Pouw

et al. 2014

European Journal of Surgical Oncology (EJSO)

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The magnetic technique for sentinel lymph node biopsy (SLNB) has been evaluated in several clinical trials, albeit under proscribed conditions. An in vivo porcine model was therefore developed to optimise the magnetic technique by evaluating the effect of differing volume of magnetic tracer and time of injection. A total of 48 sentinel node procedures were undertaken and 423 nodes (109 sentinel nodes) retrieved. There was a significant correlation between magnetometer counts and the tracer content of excised sentinel lymph nodes (SLNs) (r=0.82; p<0.001). Total numbers of tracer-containing SLNs increased with increasing volumes of tracer (p<0.001). Transcutaneous magnetometer counts increased with increasing time from injection of tracer (p<0.0001) and reached a plateau within 60 minutes. A non-statistically significant trend was observed between volume of tracer injected and tracer content of SLNs (p=0.07). We infer that increasing tracer volume and injecting prior to surgery improves transcutaneous 'hotspot' identification, but that very high injection volumes lead to an increase in the number of nodes excised.3

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“…32 The dyes were injected subdermally at the same time around the areola. The image M A N U S C R I P T…”

Section: Dyesmentioning

confidence: 99%

The use of fluorescent dyes and probes in surgical oncology

Velde

Veerman

Subramaniam

et al. 2010

European Journal of Surgical Oncology (EJSO)

133

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Aims and background: Improved visualization of surgical targets inside of the patient helps to improve radical resection of the tumor while sparing healthy surrounding tissue. In order to achieve an image, optical contrast must be generated by properties intrinsic to the tissue, or require the attachment of special visualization labels to the tumor. In this overview the current status of the clinical use of fluorescent dyes and probes are reviewed. Methods:In this review, all experimental and clinical studies concerning fluorescent imaging were included. In addition, in the search for the optimal fluorescent imaging modality, all characteristics of a fluorescent dye were described. Findings and Conclusions:Although the technique of imaging through fluorescence sounds promising and several animal models show efficacy, official approval of these agents for further clinical evaluation, is eagerly awaited.

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Intraoperative identification of sentinel lymph nodes by near-infrared fluorescence imaging in patients with breast cancer

Cited by 217 publications

References 10 publications

Neodymium-doped nanoparticles for infrared fluorescence bioimaging: The role of the host

Neodymium-doped nanoparticles for infrared fluorescence bioimaging: The role of the host

160. Optimising magnetic sentinel lymph node biopsy in an in vivo porcine model

The use of fluorescent dyes and probes in surgical oncology

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