Intraoperative Lymphatic Mapping in Cervix Cancer Patients Undergoing Radical Hysterectomy: A Pilot Study

O’Boyle, John D.; Coleman, Robert L.; Bernstein, Steven G.; Lifshitz, Samuel; Muller, Carolyn Y.; Miller, David S.

doi:10.1006/gyno.2000.5930

Cited by 145 publications

(96 citation statements)

References 18 publications

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“…Echt et al reported a SLNdetection rate for cervical cancer of 15.4% using blue dye (Echt et al, 1999). O'Boyle et al reported a detection rate of 60% in his series of 20 patients using isosulfan blue dye (O'Boyle et al, 2000). Medl et al reported that he found in all 3 cases 2 to 3 bluestained (sentinel) lymph nodes located either at the external iliac or in the obturator chain.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, cervical tumour size less than 2 cm has been associated with nodal metastases in only 0-16% of cases (Delgado et al, 1989;Magrina et al, 1999). Recently some authors described the sentinel node procedure in cervical cancer by blue dye uptake (Echt et al, 1999;Dargent et al, 2000;Medl et al, 2000;O'Boyle et al, 2000) or by lymphoscintigraphy (Kamprath et al, 2000), whereas some authors used both techniques to detect SLNs in cervical cancer. Verheijen et al found in a series of 10 patients that the typical location of sentinel nodes was the external iliac area (6 of 18 sentinel nodes) and the chain of the obturator nodes .…”

Section: Discussionmentioning

confidence: 99%

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Sentinel node procedure in Ib cervical cancer: a preliminary series

et al. 2001

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The aim of this study was to determine the diagnostic accuracy and feasibility of sentinel lymph node (SLN) detection using a gamma probe in patients with Figo IB cervical cancer. Between January 1999 and September 2000, 14 patients with cervical cancer, planned for radical hysterectomy were eligible for the study. The day before radical hysterectomy we injected technetium 99 m-labelled nanocolloid in each quadrant of the cervix. Dynamic and static images were recorded using a gamma camera. SLNs were identified intraoperatively using a handheld gamma-detection probe. After resection of SLNs a standard radical hysterectomy with pelvic lymph node dissection was performed. Patients and tumour characteristics were compared with sentinel node detection and with final histopathological and immunohistochemical results. Scintigraphy showed focal uptake in 13 of the 14 patients. Intraoperatively we detected 26 sentinel nodes by gamma probe. In 8 of 13 patients, one or more sentinel nodes were identified unilaterally, in 5 women bilaterally. Histologically positive SLNs were found in only 1 patient. We did not find any false-negative SLN in our series. In conclusion identification of sentinel nodes in cervical cancer is feasible with preoperatively administered technetium 99 m-labelled nanocolloid. A larger series will be required to establish sentinel node detection in cervical cancer for further therapy concepts and planning. © 2001 Cancer Research Campaign http://www.bjcancer.com

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sentinel node procedure in Ib cervical cancer: a preliminary series

et al. 2001

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“…SLN tutulumunun %62'sinin eksternal iliak lenf nodlarında olduğunu göstermiştir. 27 Martinez Palones ise 26 olguyu içeren çalışmasında, SLN tutulumunun %40'ının internal iliak, %25'inin eksternal lenf nodlarında olduğunu bildirilmiştir. Bir başka çalış-mada Barranger SLN tutulumunun %67'sinin eksternal iliak lenf nodlarına olduğunu rapor etmiştir.…”

Section: Servi̇ks Kanseri̇unclassified

“…28 Sonuç olarak birçok çalışma-dan yola çıkılarak SLN tutulumlarının en yaygın olarak eksternal iliak lenf nodlarına olduğu, bunu kommon iliak ve parametrial lenf nodlarının izlediği anlaşılmıştır. 27 Rhim ve ark., 21 olgu içeren çalışmasında SLN tespit etme oranını %94, toplam doğruluk oranını %97 ve yalancı negatiflik oranını %4,76 olarak tespit etmiştir. 26 Bir başka çalışmada Hauspy ve ark., yaklaşık 800 olguyu incelemişler ve SLN biyopsisindeki yanlış negatiflik oranının çok az olduğunu bildirmişlerdir.…”

Section: Servi̇ks Kanseri̇unclassified

“…Biyopsi sonucu pozitif ise lenfadenektomiye devam edilir, negatif ise lenfadenektomiye son verilir. 27 SLN çalışmaların-daki en başarılı sonuçlar kombine yöntemle ile elde edilmiştir. Malur ve ark., yaptıkları 50 hastayı içe-ren çalışmalarında, SLN saptama oranını, boyama yönteminde %55,5, radyoizotop kullanımında %76,2, kombine yöntemde ise %90 olarak saptamışlardır.…”

Section: Servi̇ks Kanseri̇unclassified

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Application of Sentinel Lymph Node Dissection in Gynecologic Cancers: Review

Balci¹,

Köşüş²,

Kaygusuz³

et al. 2015

Turkiye Klinikleri J Gynecol Obst

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Sentinel lymph node biopsy in early stage cervical cancer: A meta‐analysis

et al. 2020

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Background The aim of this study was to determine the specific side detection rate of the sentinel lymph node biopsy and the accuracy in predicting lymph node metastasis in early stage cervical cancer. Methods A systematic search of databases was performed from the inception of the databases to 27 June 2020. Studies of cervical cancer patients with FIGO stage FIGO ⅠA~ⅡB, evaluating the sentinel lymph node biopsy with blue dye, technetium 99, combined technique (blue dye with technetium 99) or indocyanine green with a reference standard of systematic pelvis lymph node dissection or clinical follow‐up were included. Stata12.0 and Meta‐Disc 1.4 were used for the meta‐analysis. Results Of 2825 articles found, 21 studies (2234 women) were eventually included. Out of 21 studies, 20 met the detection rate evaluation criteria and six were included for sensitivity meta‐analysis. Due to heterogeneity, it was inappropriate to pool all studies. The pooled specific side detection rates were 85% in tumors up to 2 cm, 67% in tumors over 2 cm, 75.2% for blue dye, 74.7% for technetium 99, 84% for combined technique, and 85.5% for indocyanine green. The sentinel lymph node biopsy had a pooled specific side sensitivity of 88%. Adverse effects of sentinel lymph node biopsy appear minimal for most patients and are mainly related to the injection of blue dye. Conclusions Sentinel lymph node biopsy using a tracer with a high detection rate and ultrastaging is highly accurate and reliable when limited to seriously selected patients, with satisfactory bilateral lymph node mapping and where enough cases for learning curve optimization exist. Indocyanine green sentinel lymph node mapping seems to be a superior sentinel lymph node mapping technique compared to other methods at present.

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Intraoperative Lymphatic Mapping in Cervix Cancer Patients Undergoing Radical Hysterectomy: A Pilot Study

Cited by 145 publications

References 18 publications

Sentinel node procedure in Ib cervical cancer: a preliminary series

Sentinel node procedure in Ib cervical cancer: a preliminary series

Application of Sentinel Lymph Node Dissection in Gynecologic Cancers: Review

Sentinel lymph node biopsy in early stage cervical cancer: A meta‐analysis

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