Intraoperative Optical and Fluorescence Imaging of Blood Flow Distributions in Mastectomy Skin Flaps for Identifying Ischemic Tissues

Mazdeyasna, Siavash; Huang, Chong; Bonaroti, Alisha R.; Mohtasebi, Mehrana; Cheng, Qiang; Wong, Lesley; Yu, Guoqiang

doi:10.1097/prs.0000000000009333

Cited by 7 publications

(8 citation statements)

References 27 publications

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“…NIR diffuse optical instrumentation capable of noninvasively penetrating the deep brain offers a unique opportunity for CBF and LFO analyses 16 , 37 , 66 . Among various NIR instruments, noncontact scDCT enables 3D imaging of CBF with flexible FOV and S–D arrangements for use across a wide range of subjects with varied head sizes within a low-cost package 48 , 49 , 52 , 54 , 55 , 57 , 62 . However, this system was hindered in extracting LFOs due to an insufficient temporal sampling rate.…”

Section: Discussionmentioning

confidence: 99%

“…9/861,319, 2018 47 ) technology provides a noninvasive, fully noncontact, low-cost, and portable tool for high-density 3D imaging of blood flow distributions in deep tissue volumes (up to ∼10 mm) 48 – 50 Importantly, this device remedies many previous limitations while offering direct CBF imaging for potential LFO assessments. In contrast to the NIRS, DCS, and HD-DOT systems using discrete detectors, scDCT uses a complementary metal-oxide semiconductor (CMOS) camera with thousands of pixels to serve as parallel 2D detectors, which dramatically increases the sampling density and enables a wide FOV.…”

Section: Introductionmentioning

confidence: 99%

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Detection of low-frequency oscillations in neonatal piglets with speckle contrast diffuse correlation tomography

et al. 2023

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Significance: Low-frequency oscillations (LFOs) (<0.1 Hz) with respect to cerebral blood flow (CBF) have shown promise as an indicator of altered neurologic activity in the abnormal brain. Portable optical instruments have evolved to offer a noninvasive alternative for continuous CBF monitoring at the bedside compared with many large neuroimaging modalities. However, their utilization for acquiring LFOs of CBF has only been studied to a limited extent.Aim: We aim to optimize an innovative speckle contrast diffuse correlation tomography (scDCT) system for the detection of LFOs within CBF variations. Approach:The scDCT was optimized to achieve a higher sampling rate and a faster image reconstruction using a moving window 3D reconstruction algorithm with parallel computation. Power spectral density (PSD) analysis was performed to investigate altered LFOs during transient global cerebral ischemia in neonatal piglets.Results: Transient global cerebral ischemia resulted in reductions in both CBF and PSD compared with their baseline values.Conclusions: Spontaneous LFOs, combined with CBF, provide a more comprehensive assay with the potential to clarify pathological mechanisms involved in brain injury. These results support scDCT's inclusion and application in the growing area of LFO analysis and demonstrate its inherent advantage for neurological studies in preclinical and clinical settings, such as neonatal intensive care units.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Detection of low-frequency oscillations in neonatal piglets with speckle contrast diffuse correlation tomography

et al. 2023

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“…Indocyanine green fluorescence angiography (ICGA) uses a dye administered intravenously that emits diffuse fluorescence when exposed to light with wave frequencies close to infrared (NIR). The device is equipped with a camera that allows one to evaluate, in this way, the perfusion of tissue in real time and is an accepted tool for intraoperative evaluation of mastectomy flaps and free flaps [ 4 , 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, this method of rescuing the amputated segments is not routine, and it is not clear what conditions can establish venous congestion [ 3 ]. Indocyanine green angiography (IGA) is increasingly used as a monitoring technique for free flaps and mastectomy flaps, proving sensitive in detecting perfusion problems and venous congestion [ 4 , 5 ]. In this case report, we present the potential of indocyanine green in assessing a thumb replantation arterialization of a vein in a 40-year-old smoker patient following a crush trauma.…”

Section: Introductionmentioning

confidence: 99%

Evaluating Arterialized Vein in Thumb Replantation using Indocyanine Green Angiography: A Case Report

Costa,

Colonna,

Vindigni

et al. 2023

Am J Case Rep

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Patient: Male, 44-year-old Final Diagnosis: Amputated thumb Symptoms: Amputated thumb Clinical Procedure: — Specialty: Plastic Surgery • Surgery Objective: Unusual clinical course Background: The absence of valid vessels for the anastomosis constitutes a contraindication to replantation, but the need for arterial vessels in good condition has recently been questioned and some authors have proposed the arterialization of the veins with promising results. However, this method is not routine in replantation and it is unclear what conditions can establish venous congestion and loss of the replanted segment. Case Report: We detail a case where indocyanine green aids in evaluating arterialization of a vein during thumb replantation in a 40-year-old smoker following a crush injury. Multiple attempts to anastomose the princeps pollicis and its collateral vessel failed due to a thrombus formation, leaving the finger non-perfused despite urokinase treatment. To confirm the absence of reperfusion, we administered 0.3 mg/kg of indocyanine green through an upper limb peripheral vein. Observing no reperfusion, we located a suitable radial dorsal vein and performed an arteriovenous anastomosis at the proximal phalanx level. Indocyanine Green Angiography (IGA) revealed a slightly delayed reperfusion but a effective venous outflow. We did not consider it necessary to perform additional venous anastomoses other than the single dorsal radial venous anastomosis. Conclusions: This single case report shows the potential of indocyanine green as a valid aid to evaluate the perfusion of the replantation and also any early venous congestion, being able to modify the operative plan accordingly.

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“…We have developed an innovative speckle contrast diffuse correlation tomography (scDCT; US Patent #9/861,319, 2018 18 ) method, which provides a noncontact, inexpensive, and portable tool for 3D imaging of blood flow distributions over a large FOV in relatively deep tissue volumes (up to ∼10 mm depth) 19 – 28 These advanced CCD/CMOS-based techniques are inherently founded upon the same concept despite differences in nomenclature and technological evolution.…”

Section: Introductionmentioning

confidence: 99%

Depth-sensitive diffuse speckle contrast topography for high-density mapping of cerebral blood flow in rodents

Mohtasebi,

Singh,

Liu

et al. 2023

Neurophoton.

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Frequent assessment of cerebral blood flow (CBF) is crucial for the diagnosis and management of cerebral vascular diseases. In contrast to large and expensive imaging modalities, such as nuclear medicine and magnetic resonance imaging, optical imaging techniques are portable and inexpensive tools for continuous measurements of cerebral hemodynamics. The recent development of an innovative noncontact speckle contrast diffuse correlation tomography (scDCT) enables three-dimensional (3D) imaging of CBF distributions. However, scDCT requires complex and time-consuming 3D reconstruction, which limits its ability to achieve high spatial resolution without sacrificing temporal resolution and computational efficiency.Aim: We investigate a new diffuse speckle contrast topography (DSCT) method with parallel computation for analyzing scDCT data to achieve fast and high-density two-dimensional (2D) mapping of CBF distributions at different depths without the need for 3D reconstruction.Approach: A new moving window method was adapted to improve the sampling rate of DSCT. A fast computation method utilizing MATLAB functions in the Image Processing Toolbox™ and Parallel Computing Toolbox™ was developed to rapidly generate high-density CBF maps. The new DSCT method was tested for spatial resolution and depth sensitivity in head-simulating layered phantoms and invivo rodent models.Results: DSCT enables 2D mapping of the particle flow in the phantom at different depths through the top layer with varied thicknesses. Both DSCT and scDCT enable the detection of global and regional CBF changes in deep brains of adult rats. However, DSCT achieves fast and high-density 2D mapping of CBF distributions at different depths without the need for complex and time-consuming 3D reconstruction. Conclusions:The depth-sensitive DSCT method has the potential to be used as a noninvasive, noncontact, fast, high resolution, portable, and inexpensive brain imager for basic neuroscience research in small animal models and for translational studies in human neonates.

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Intraoperative Optical and Fluorescence Imaging of Blood Flow Distributions in Mastectomy Skin Flaps for Identifying Ischemic Tissues

Cited by 7 publications

References 27 publications

Detection of low-frequency oscillations in neonatal piglets with speckle contrast diffuse correlation tomography

Detection of low-frequency oscillations in neonatal piglets with speckle contrast diffuse correlation tomography

Evaluating Arterialized Vein in Thumb Replantation using Indocyanine Green Angiography: A Case Report

Depth-sensitive diffuse speckle contrast topography for high-density mapping of cerebral blood flow in rodents

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