Intraoperative Pleural Lavage in Esophageal Carcinoma

Natsugoe, Shoji; Shimada, Mario; Nakashima, Saburo; Tokuda, Koki; Matsumoto, Masataka; Kijima, Fumio; Baba, Masamichi; Shimizu, Ken; Tanaka, Sadao; Aikou, Takashi

doi:10.1007/s10434-999-0305-z

Cited by 8 publications

(4 citation statements)

References 9 publications

(3 reference statements)

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“…resection of thoracic ESCC has been reported, and positive pleural lavage cytology has been recognized as a prognostic indicator of recurrence (1,3). However, esophageal carcinomas are less likely to spontaneously exfoliate into the pleural cavity because most of the thoracic esophagus is not covered directly by the pleura but by adventitia.…”

Section: Discussionmentioning

confidence: 99%

“…The presence of exfoliated cancer cells in the pleural cavity after resection of thoracic esophageal carcinoma has been reported (1)(2)(3)(4), and positive pleural lavage cytology before thoracic closure is recognized as a prognostic indicator of recurrence in thoracic esophageal carcinoma (1,3). Therefore, effective pleural lavage is clinically important at the time of initial surgery of thoracic esophageal carcinoma because exfoliated cancer cells may be viable and tumorigenic.…”

Section: Introductionmentioning

confidence: 99%

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Pleural lavage with distilled water during surgery for esophageal squamous cell carcinoma

Kosuga

Shiozaki

Ichikawa³

et al. 2011

Oncol Rep

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Abstract. This study aimed to investigate cytocidal effects of hypotonic shock on esophageal squamous cell carcinoma (ESCC) cell lines, and to apply pleural lavage with distilled water to surgery for ESCC. Three human ESCC cell lines, TE5, TE9 and KYSE170 were exposed to distilled water, and morphological changes in ESCC cells were closely observed under a differential interference contrast microscope connected to a high-speed digital video camera. Further, serial cell volume changes after hypotonic shock were measured using a high-resolution flow cytometer. To investigate the cytocidal effects of hypotonic shock on ESCC cells, re-incubation of ESCC cells was performed after hypotonic shock. Additionally, the effects of 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB), a Cl -channel blocker, during hypotonic shock were analyzed. Video recordings by high-speed digital camera demonstrated that hypotonic shock with distilled water induced cell swelling followed by cell rupture. Measurements of cell volume changes using a high-resolution flow cytometer indicated that severe hypotonicity with distilled water increased broken fragments of ESCC cells within 5 min. Re-incubation experiments demonstrated cytocidal effects of hypotonic shock on ESCC cells. Treatment of cells with NPPB increased cell volumes by the inhibition of regulatory volume decrease, which is observed during hypotonic shock, and enhanced cytocidal effects. These findings demonstrated the cytocidal effects of hypotonic shock on ESCC cells, and clearly support the efficacy of pleural lavage with distilled water during surgery for ESCC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pleural lavage with distilled water during surgery for esophageal squamous cell carcinoma

Kosuga

Shiozaki

Ichikawa³

et al. 2011

Oncol Rep

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“…However, the benefit may also be ascribed to a wider circumferential margin clearance 12 and it may be that resection of the pleural surfaces may also have prognostic implications. For instance, it has been shown that positive cytology of pleural lavage specimens may be predictive of local recurrence 22,23 . Involvement of the pleura is certainly one of the parameters assessed when performing preoperative staging laparotomy/thoracoscopy for oesophageal cancer 24,25 .…”

Section: The Significance Of Serosal Involvementmentioning

confidence: 99%

Serosal involvement in gastrointestinal cancer: its assessment and significance

Ludeman

Shepherd

2005

Histopathology

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There is an increasing burden upon diagnostic histopathologists to identify accurately factors of prognostic and therapeutic implication in gastrointestinal cancer. It is perhaps partly because of the use of rigid sequential staging systems, such as the Dukes' classification, that some factors, perhaps most notably involvement of surgical margins (especially in rectal cancer) and serosal involvement (particularly in oesophageal, colonic and rectal cancer), have been relatively neglected until more recently. This is surprising and concerning because both of these pathologically derived parameters strongly correlate with subsequent locoregional recurrence and, ultimately, with prognosis. Whilst the occurrence and significance of serosal involvement have been well recognized in gastric cancer for many years, relatively little attention has been paid to the phenomenon in oesophageal cancer and yet both pleural and peritoneal involvement may be comparatively commonly identified in oesophageal cancer. Serosal involvement and transperitoneal spread are also of considerable prognostic importance in primary appendiceal carcinoma. Only more recently has the significance of serosal involvement been appreciated in colonic and rectal cancer. In the colon, the phenomenon is now recognized to be one of the most important factors in predicting transperitoneal spread and overall prognosis. Furthermore, there is increasing interest in alternative novel strategies, including intraperitoneal chemotherapy and radical peritoneal surgery, as legitimate therapeutic options in many gastrointestinal cancers.

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“…Previous studies have revealed that the detection of free cancer cells using lavage cytology is useful for predicting the recurrence and prognosis of lung, gastric, pancreatic, and colorectal cancers [8][9][10][11][12][13][14][15][16][17][18][19][20]. According to recent reports [21][22][23], the positivity rate of pleural lavage cytology at the beginning of the operation is only 0-1% for esophageal cancer. By contrast, the positivity rate of pleural lavage cytology after mediastinal lymphadenectomy is 5-9%.…”

Section: Introductionmentioning

confidence: 99%

The Significance of SCC and CEA mRNA in the Pleural Cavity After Lymphadenectomy in Esophageal Cancer Patients who Underwent Preoperative Treatment

et al. 2017

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Intraoperative Pleural Lavage in Esophageal Carcinoma

Abstract: Positive cytological findings for pleural lavage fluid, using Papanicolaou and Giemsa staining, is correlated with regrowth of residual tumor and poor prognosis in esophageal carcinoma.

Cited by 8 publications

References 9 publications

Pleural lavage with distilled water during surgery for esophageal squamous cell carcinoma

Pleural lavage with distilled water during surgery for esophageal squamous cell carcinoma

Serosal involvement in gastrointestinal cancer: its assessment and significance

The Significance of SCC and CEA mRNA in the Pleural Cavity After Lymphadenectomy in Esophageal Cancer Patients who Underwent Preoperative Treatment

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